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Articles 1 - 9 of 9
Full-Text Articles in Entire DC Network
Om92, A Glp-1 Enhancer Mutation, Is An Allele Of Ekl-1, Samantha A. Stein, Olivia F. Zucaro, Harold E. Smith, Kevin F. O'Connell, Jill M. Spoerke, Eleanor M. Maine, James L. Lissemore
Om92, A Glp-1 Enhancer Mutation, Is An Allele Of Ekl-1, Samantha A. Stein, Olivia F. Zucaro, Harold E. Smith, Kevin F. O'Connell, Jill M. Spoerke, Eleanor M. Maine, James L. Lissemore
2022 Faculty Bibliography
Germline stem cell proliferation in C. elegans requires activation of the GLP-1/Notch receptor, which is located on the germline plasma membrane and encoded by the glp-1 gene. We previously identified several genes whose products directly or indirectly promote activity of the GLP-1 signaling pathway by finding mutations that enhance the germline phenotype of a glp-1(ts) allele, glp-1(bn18) . Here, we report phenotypic and molecular analysis of a new ekl-1 allele, ekl-1(om92) , that enhances the glp-1(bn18) phenotype. ekl-1(om92) is a 244 bp deletion predicted to generate a frameshift and premature termination codon, yielding a severely truncated protein, suggesting it is …
Gender Differences And The Influence Of Body Composition On Land And Pool-Based Assessments Of Anaerobic Power And Capacity, Jacquelyn N. Zera, Elizabeth F. Nagle, Emma Connell, Erin Curtin, Wilmina Marget, Anna P. Simonson, Takashi Nagai, John Abt, Scott Lephart
Gender Differences And The Influence Of Body Composition On Land And Pool-Based Assessments Of Anaerobic Power And Capacity, Jacquelyn N. Zera, Elizabeth F. Nagle, Emma Connell, Erin Curtin, Wilmina Marget, Anna P. Simonson, Takashi Nagai, John Abt, Scott Lephart
2022 Faculty Bibliography
No abstract provided.
Does The Thermal Mismatch Hypothesis Predict Disease Outcomes In Different Morphs Of A Terrestrial Salamander?, Matthew Venesky, Joseph Alan Demarchi, Cari-Ann M. Hickerson, Carl D. Anthony
Does The Thermal Mismatch Hypothesis Predict Disease Outcomes In Different Morphs Of A Terrestrial Salamander?, Matthew Venesky, Joseph Alan Demarchi, Cari-Ann M. Hickerson, Carl D. Anthony
2022 Faculty Bibliography
Many aspects of ectotherm physiology are temperature‐dependent. The immune system of temperate‐dwelling ectothermic host species is no exception and their immune function is often downregulated in cold temperatures. Likewise, species of ectothermic pathogens experience temperature‐mediated effects on rates of transmission and/or virulence. Although seemingly straightforward, predicting the outcomes of ectothermic host−pathogen interactions is quite challenging. A recent hypothesis termed the thermal mismatch hypothesis posits that cool‐adapted host species should be most susceptible to pathogen infection during warm temperature periods whereas warm‐adapted host species should be most susceptible to pathogens during periods of cool temperatures. We explore this hypothesis using two …
Hybridization Between The Woodland Salamanders Plethodon Cinereus And P. Electromorphus Is Not Widespread, Shawn R. Kuchta, Maggie M. Hantak, Brian P. Waldron, Cari-Ann M. Hickerson, Richard M. Lehtinen, Carl Anthony
Hybridization Between The Woodland Salamanders Plethodon Cinereus And P. Electromorphus Is Not Widespread, Shawn R. Kuchta, Maggie M. Hantak, Brian P. Waldron, Cari-Ann M. Hickerson, Richard M. Lehtinen, Carl Anthony
2022 Faculty Bibliography
A recent study reported widespread hybridization between the Eastern Red-backed Salamander (Plethodon cinereus) and the Northern Ravine Salamander (P. electromorphus) in northern Ohio. In this study, DNA sequence data were obtained from three nuclear loci and 20 single nucleotide polymorphisms (SNPs) were identified from the sequences. They found that 48 out of 90 individuals from 13 populations were hybrids, and in some localities every individual possessed an admixed genotype. As these results contradict our observations, and because levels of hybridization impact our interpretation of past and ongoing studies, we revisited the data. First we reanalyzed the original SNPs using STRUCTURE, …
Dose-Dependent Alkaloid Sequestration And N-Methylation Of Decahydroquinoline In Poison Frogs, Adriana M. Jeckel, Sarah K. Bolton, Katherine R. Waters, Marta M. Antoniazzi, Carlos Jared, Kunihiro Matsumura, Keisuke Nishikawa, Yoshiki Morimoto5, Taran Grant, Ralph Saporito
Dose-Dependent Alkaloid Sequestration And N-Methylation Of Decahydroquinoline In Poison Frogs, Adriana M. Jeckel, Sarah K. Bolton, Katherine R. Waters, Marta M. Antoniazzi, Carlos Jared, Kunihiro Matsumura, Keisuke Nishikawa, Yoshiki Morimoto5, Taran Grant, Ralph Saporito
2022 Faculty Bibliography
Sequestration of chemical defenses from dietary sources is dependent on the availability of compounds in the environment and the mechanism of sequestration. Previous experiments have shown that sequestration efficiency varies among alkaloids in poison frogs, but little is known about the underlying mechanism. The aim of this study was to quantify the extent to which alkaloid sequestration and modification are dependent on alkaloid availability and/or sequestration mechanism. To do this, we administered different doses of histrionicotoxin (HTX) 235A and decahydroquinoline (DHQ) to captive‐bred Adelphobates galactonotus and measured alkaloid quantity in muscle, kidney, liver, and feces. HTX 235A and DHQ were …
Effects Of Chronic Oral Administration Of Midazolam On Memory And Circadian Rhythms In Rats, Helen M. Murphy, Anastasiya I. Kalinina, Cyrilla H. Wideman
Effects Of Chronic Oral Administration Of Midazolam On Memory And Circadian Rhythms In Rats, Helen M. Murphy, Anastasiya I. Kalinina, Cyrilla H. Wideman
2022 Faculty Bibliography
Studies have shown the ability of benzodiazepine drugs to cause memory loss in animals and humans. Midazolam is a benzodiazepine commonly administered intravenously during surgical procedures because it reacts rapidly, causes anterograde amnesia, and has few side effects. It has also been used in palliative medicine where, among others, an oral route has been employed for chronic administration of the drug. The current study evaluated the effects of chronic orally administered midazolam on spatial working memory and procedural memory in control and experimental female rats over a threeweek experimental period utilizing the Morris water maze. Sample and test run times …
Circumscription Of Fulbrightiella Gen. Nov. And Sherwoodiella Gen. Nov., Two Novel Genera In The Calotrichaceae (Nostocales, Cyanobacteria), Naresh Kumar, Aniket Saraf, Sagarika Paul, Deeksha Mishra, Prashant Singh, Jeffrey R. Johansen
Circumscription Of Fulbrightiella Gen. Nov. And Sherwoodiella Gen. Nov., Two Novel Genera In The Calotrichaceae (Nostocales, Cyanobacteria), Naresh Kumar, Aniket Saraf, Sagarika Paul, Deeksha Mishra, Prashant Singh, Jeffrey R. Johansen
2022 Faculty Bibliography
Three novel strains in Calotrichaceae from tropical habitats were isolated and characterized with regard to their morphology, phylogenetic placement, and secondary structures of conserved domains in the 16S‐23S internal transcribed spacer (ITS). The strains fell into two clades formerly identified as Calothrix from freshwater and brackish habitats. Based on both morphology and ecology, they differed from the type species of Calothrix, C. confervicola, which is marine, has wide trichomes with short cells, and narrows abruptly to a hyaline hair. The first clade grouped species with heteropolar filaments widened at the base and narrowed gradually toward the apex but not ending …
Roholtiella Volcanica Sp. Nov., A New Species Of Cyanobacteria From Kamchatkan Volcanic Soils, Lira A. Gaysina, Jeffrey R. Johansen, Aniket Saraf, Razeda Z. Allaguvatova, Sagarika Paul, Prashant Singh
Roholtiella Volcanica Sp. Nov., A New Species Of Cyanobacteria From Kamchatkan Volcanic Soils, Lira A. Gaysina, Jeffrey R. Johansen, Aniket Saraf, Razeda Z. Allaguvatova, Sagarika Paul, Prashant Singh
2022 Faculty Bibliography
During a study of biodiversity of cyanobacteria in Gorely volcano soils (Kamchatka Peninsula), a strain of heterocytous, a false branching cyanobacterium with gradually tapered filaments, was isolated. Prominent features of the strain were purplish-grey trichomes and firm, distinct multilayered sheaths. Based on the results obtained from the morphological, ecological, and phylogenetic analysis using the 16S rRNA and 16S–23S ITS region, 16S–23S ITS secondary structure analysis, comparison of flanking regions of BoxB and V3 helices, and the p-distance between the 16S–23S ITS region, we describe our strain K7 as a novel species of the genus Roholtiella with the name Roholtiella volcanica …
Deoxybuzonamine Isomers From The Millipede Brachycybe Lecontii (Platydesmida: Andrognathidae), Tappy H. Jones, Daniel P. Harrison, Carla Menegatti, Emily Levers, Kenneth Knott, Paul Marek, Derek A. Hennen, Matt T. Kasson, Angie M. Macias, Brian Lovett, Ralph Saporito
Deoxybuzonamine Isomers From The Millipede Brachycybe Lecontii (Platydesmida: Andrognathidae), Tappy H. Jones, Daniel P. Harrison, Carla Menegatti, Emily Levers, Kenneth Knott, Paul Marek, Derek A. Hennen, Matt T. Kasson, Angie M. Macias, Brian Lovett, Ralph Saporito
2022 Faculty Bibliography
Millipedes (Diplopoda) are well known for their toxic or repellent defensive secretions. Here, we describe (6aR,10aS,10bR)-8,8-dimethyldodecahydropyrrolo[2,1-a]isoquinoline [trans-anti-trans-deoxybuzonamine (1a)] and (rel-6aR,10aR,10bR)-8,8-dimethyldodecahydropyrrolo[2,1-a]isoquinoline [trans-syn-cis-deoxybuzonamine (1b)], two isomers of deoxybuzonamine found in the chemical defense secretions of the millipede Brachycybe lecontii Wood (Colobognatha, Platydesmida, Andrognathidae). The carbon–nitrogen skeleton of these compounds was determined from their MS and GC-FTIR spectra obtained from the MeOH extract of whole millipedes, along with a subsequent selective synthesis. Their structures were established from their 1D (¹H, ¹³C) and 2D NMR (COSY, NOESY, multiplicity-edited HSQC, HSQC-TOCSY, HMBC) spectra. Additionally, computational chemistry (DFT and DP4) was used to identify the relative …