Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Activation Of Gabaa And 5ht1a Receptors In The Raphe Pallidus Abolish The Cardiovascular Responses To Stress In Conscious Rats, Nhut Minh Pham Le
Activation Of Gabaa And 5ht1a Receptors In The Raphe Pallidus Abolish The Cardiovascular Responses To Stress In Conscious Rats, Nhut Minh Pham Le
Masters Theses, 2010-2019
Serotonergic neurons of the raphe pallidus area of the brainstem are involved in the cardiovascular responses to stress. However, the manner in which they mediate these responses is not well understood and severe abnormalities in this system have been associated with Sudden Infant Death Syndrome. In the current study, microinjections of muscimol and 8-OH-DPAT (GABAA and 5HT1A receptor agonists, respectively) into the raphe pallidus abolished the increase in mean arterial pressure and the tachycardiac responses following air jet, handing, and restraint stress that were observed following microinjections of artificial cerebrospinal fluid. The stress responses following muscimol microinjections suggest that this …