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The Role Of Brain Stem 5-Ht1a And Gaba-A Receptors In The Thermoregulatory Response To Hypoxic Stress, Alexander Schmidt
The Role Of Brain Stem 5-Ht1a And Gaba-A Receptors In The Thermoregulatory Response To Hypoxic Stress, Alexander Schmidt
Senior Honors Projects, 2010-2019
Sudden Infant Death Syndrome (SIDS) is a leading cause of infant mortality. Alterations in brainstem development of Serotonin (5HT) and γ-aminobutyric acid (GABA) are linked to its cause. The sympathetic premotor neurons located in the Nucleus of the Raphe Pallidus (NRP) in the brainstem have both 5-HT1A and GABA-A receptor subtypes that mediate protective cardiovascular responses to environmental stress. It is hypothesized that alteration in these receptors at the NRP will also modify protective thermoregulatory responses to hypoxic stress such as hypothermia. Using aseptic techniques, male and female Sprague-Dawley rats (230-385g) were instrumented with radiotelemetry probes to non-invasively measure core …