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Interleukin-3 Promotes Susceptibility In A Mouse Model Of Cutaneous Leishmaniasis, Bryan Lewis Saunders

Masters Theses, 2010-2019

Cutaneous leishmaniasis (CL), a vector-borne infectious disease caused by protozoan parasites of the genus Leishmania, is one of the most important neglected infectious diseases worldwide. Currently, 10 million people in 82 (mostly developing) countries are infected. Those infected develop ulcerative skin lesions on exposed parts of the body, causing serious disability and permanent scarring. All mice are susceptible to infection with Leishmania major, however, the outcome of infection is different depending on the mouse strain. For example, resistant C57BL/6 mice develop lesions, which like in humans, ultimately heal. In contrast, lesions in susceptible BALB/c mice progressively worsen, ultimately resulting in …