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Rapid Signaling At The Plasma Membrane By A Nuclear Receptor For Thyroid Hormone, Hemayet Ullah
Rapid Signaling At The Plasma Membrane By A Nuclear Receptor For Thyroid Hormone, Hemayet Ullah
Department of Biology Faculty Publications
Many nuclear hormones have physiological effects that are too rapid to be explained by changes in gene expression and are often attributed to unidentified or novel G protein-coupled receptors. Thyroid hormone is essential for normal human brain development, but the molecular mechanisms responsible for its effects remain to be identified. Here, we present direct molecular evidence for potassium channel stimulation in a rat pituitary cell line (GH(4)C(1)) by a nuclear receptor for thyroid hormone, TRbeta, acting rapidly at the plasma membrane through phosphatidylinositol 3-kinase (PI3K) to slow the deactivation of KCNH2 channels already in the membrane. Signaling was disrupted by …
Ethnic Identity And Type 2 Diabetes Health Attitudes In Americans Of African Ancestry, Jelena Brezo, Charmaine D. Royal, Franklin Ampy, Verle Headings
Ethnic Identity And Type 2 Diabetes Health Attitudes In Americans Of African Ancestry, Jelena Brezo, Charmaine D. Royal, Franklin Ampy, Verle Headings
Department of Biology Faculty Publications
Background: Exploring the role of ethnic identity may be a good starting point toward a better understanding of health attitudes in different communities. This knowledge would be most useful in addressing diseases that cause significant burden and for which known prevention and morbidity-reducing strategies are effective.Objective: The main objective was to investigate possible associations between measures of ethnic identity and health attitudes toward type 2 diabetes mellitus by using a questionnaire-based measure.
African-American Mitochondrial Dnas Often Match Mtdnas Found In Multiple African Ethnic Groups [Published Correction Appears In Bmc Biol 2006; 5:13], Bert Ely, Jamie Wilson, Fatimah Linda Collier Jackson, Bruce Jackson
African-American Mitochondrial Dnas Often Match Mtdnas Found In Multiple African Ethnic Groups [Published Correction Appears In Bmc Biol 2006; 5:13], Bert Ely, Jamie Wilson, Fatimah Linda Collier Jackson, Bruce Jackson
Department of Biology Faculty Publications
Mitochondrial DNA (mtDNA) haplotypes have become popular tools for tracing maternal ancestry, and several companies offer this service to the general public. Numerous studies have demonstrated that human mtDNA haplotypes can be used with confidence to identify the continent where the haplotype originated. Ideally, mtDNA haplotypes could also be used to identify a particular country or ethnic group from which the maternal ancestor emanated. However, the geographic distribution of mtDNA haplotypes is greatly influenced by the movement of both individuals and population groups. Consequently, common mtDNA haplotypes are shared among multiple ethnic groups. We have studied the distribution of mtDNA …
Rack1 Mediates Multiple Hormone Responsiveness And Developmental Processes In Arabidopsis, Hemayet Ullah
Rack1 Mediates Multiple Hormone Responsiveness And Developmental Processes In Arabidopsis, Hemayet Ullah
Department of Biology Faculty Publications
The scaffold protein RACK1 (Receptor for Activated C Kinase 1) serves as an integrative point for diverse signal transduction pathways. The Arabidopsis genome contains three RACK1 orthologues, however, little is known about their functions. It is reported here that one memberof this gene family, RACK1A, previously identified as the Arabidopsis homologue of the tobacco arcA gene, mediates hormone responses and plays a regulatory role in multiple developmental processes. RACK1A expresses ubiquitously in Arabidopsis. Loss-of-function mutations in RACK1A confer defects in multiple developmental processes including seed germination, leaf production, and flowering. rack1a mutants displayed reduced sensitivity to gibberellin and brassinosteroid in …