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Characterization Of The Structure, Function And Assembly Of The Drrab Antibiotic Efflux Pump In Streptomyces Peucetius, Divya Kishore Rao
Characterization Of The Structure, Function And Assembly Of The Drrab Antibiotic Efflux Pump In Streptomyces Peucetius, Divya Kishore Rao
Biology Dissertations
ATP binding cassette (ABC) transporters constitute one of the largest families of transport proteins. The occurrence of multidrug resistance (MDR) in human cancer cells has been correlated with the over expression of human ABC, P-glycoprotein (Pgp). Streptomyces peucetius produces two anticancer agents, doxorubicin and daunorubicin, that belong to the anthracycline family of antibiotics. The organism is self-resistant to the potent effects of the antibiotics it produces due to the action of an efflux pump, DrrAB. Both Pgp and DrrAB carry out similar functions, but in two different cell types. An understanding of the bacterial drug transporter DrrAB is thus expected …
Bartonella Bacilliformis: Understanding The Underlying Causes Of Verruga Peruana Formation During Carrion?S Disease, Drew Eric Kohlhorst
Bartonella Bacilliformis: Understanding The Underlying Causes Of Verruga Peruana Formation During Carrion?S Disease, Drew Eric Kohlhorst
Biology Dissertations
Bartonella, a group of Gram negative facultative intracellular bacteria, are known to cause diseases, such as Cat Scratch Disease, Trench Fever and Carrion’s Disease, that involve angiogenesis during the infective cycle. B. bacilliformis, the etiological agent of Carrion’s Disease, causes a bi-phasic infection resulting in the formation of blood-filled angiogenic proliferative cutaneous nodules called verruga peruana. The work presented here was undertaken to characterize the mechanism by which these nodules are produced. Previous work in our laboratory suggested that the Bartonella henselae genome contains a homologue to the virB operon, a set of genes coding for a Type IV Secretion …