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Gene Knockout Of Prfa And The Arginine Deiminase Pathway In Listeria Monocytogenes, Kearstin Edmonds
Gene Knockout Of Prfa And The Arginine Deiminase Pathway In Listeria Monocytogenes, Kearstin Edmonds
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Listeria monocytogenes is a Gram-positive facultative intracellular pathogen. This species is a common cause of food-borne illness outbreaks with high fatality rates. L. monocytogenes is known to produce a number of virulence factors, including enzymes and toxins, which are involved in the disease process. The arginine deiminase pathway has the ability to regulate acidic environments by converting arginine to ammonia, ornithine, and ATP. With the help of a membrane-bound antiporter, the ornithine is transported out of the cell while the ammonia is converted to ammonium. The ATP by-product can also be used with the F0F1-ATPase system to help maintain homeostasis. …