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Genetic Analysis Of A Novel Ftsk Homolog, Hfka, In Streptomyces Coelicolor Development-Associated Chromosome Segregation, Sumedha Sethi

Electronic Theses and Dissertations

A quintessential phenomenon occurring during prokaryotic development is accurate segregation of the replicated genomes into the daughter cells. Key energy-dependent processes like chromosome condensation and subcellular partitioning of the genomes are driven by conserved proteins like SMC, ParB, FtsK. During its complex developmental cycle, Streptomyces coelicolor segregates its genomes into chains of unicellular spores when its multigenomic syncytial aerial hyphae undergo division.

A novel ftsK-like gene, hfkA (Homolog of FtsK protein A), was examined for function and localization during development-associated chromosome segregation. Individual deletions did not affect segregation, but a ΔhfkA ΔftsK mutant exhibited 8% anucleate …

The Role Of Sibling Configuration In Identity And Career Development, Alyssa Sullinger

Electronic Theses and Dissertations

This synthetic literature review examines the characteristics of sibling configurations— which refer to the ordinal position of siblings, age spacing, and sex composition—in a traditional family setting. A general review of the literature on sibling configurations and relationships is presented, and their potential roles in the development of personality traits, self-concept and identity, and career choices are explored. This synthesis describes how sibling birth rank is affiliated with generalized personality traits and likelihood of siblings with these traits identifying with corresponding career interest-types associated with Holland’s vocational theory. Suggestions for future research include empirical studies investigating these connections, such the …