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Proteins Involved In Hdaci Induced Decay Of Erbb2 Transcripts In Breast Cancer, Sadaf Malik
Proteins Involved In Hdaci Induced Decay Of Erbb2 Transcripts In Breast Cancer, Sadaf Malik
Dissertations, Masters Theses, Capstones, and Culminating Projects
ERBB2-positive breast cancer is an aggressive disease form that can result in rapid tumor growth and metastasis driven by the overexpression of ERBB2 growth factor receptors present on the cell surface. Currently, approved agents can target and disable ERBB2 receptor function, but as few as 30% of patients with disseminated ERBB2-positive breast cancer will respond to these targeted therapeutics when given as single agents. Even then, many initial responders will soon develop resistance to these agents. Histone deacetylase inhibitors (HDACi) are a powerful new class of epigenetic therapeutics that have demonstrated potent antitumor activity. However, there are several concerns that …
Dual Mtor/Hdac Inhibition: Preclinical Development Of A Novel Breast Cancer Therapy, Mariya Alexandra Yevtushenko
Dual Mtor/Hdac Inhibition: Preclinical Development Of A Novel Breast Cancer Therapy, Mariya Alexandra Yevtushenko
Dissertations, Masters Theses, Capstones, and Culminating Projects
HER2 (human epidermal growth factor receptor-2) and/or estrogen receptor (ER) are overexpressed in ~80% of human breast cancers. Although modern therapeutics (e.g. Trastuzumab, Tamoxifen) target the HER2 and ER receptors, clinical resistance often develops due to activation of downstream signaling pathways, including phosphoinositide 3 kinase-AKT/protein kinase Bmammalian target of rapamycin (PI3K/AKT/mTOR), despite effective upstream receptor inhibition. Activation of this pathway increases ribosome biogenesis and translation of oncogenic mRNAs, which are controlled by intracellular histone deacetylase (HDAC) activity as well. In fact, HDAC inhibitors that have been implemented into clinical practice are capable of overcoming resistance to HER2 and ER targeted …
The Effects Of Chronic Cadmium Exposure On Breast Cancer Progression, Esmeralda Ponce
The Effects Of Chronic Cadmium Exposure On Breast Cancer Progression, Esmeralda Ponce
Dissertations, Masters Theses, Capstones, and Culminating Projects
Cadmium is an environmental contaminant that enters the body usually through diet or cigarette smoke. Exposure to cadmium has been associated with the development of breast cancer. Recent studies have suggested that cadmium functions as an endocrine disruptor and mimics the actions of estrogen in breast cancer cells by activating the receptor (ER) to promote breast cancer cell growth. Although acute cadmium exposure is known to promote estrogen receptor-mediated gene expression associated with growth, the consequence of chronic cadmium exposure has been unclear. Since heavy metals are known to bioaccumulate, it is necessary to understand and elucidate the effects of …