Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
The Kinesin-13 Proteins Kif2a, Kif2b, And Kif2c/Mcak Have Distinct Roles During Mitosis In Human Cells, Amity L. Manning, Neil J. Ganem, Samuel F. Bakhoum, Michael Wagenbach, Linda Wordeman, Duane A. Compton
The Kinesin-13 Proteins Kif2a, Kif2b, And Kif2c/Mcak Have Distinct Roles During Mitosis In Human Cells, Amity L. Manning, Neil J. Ganem, Samuel F. Bakhoum, Michael Wagenbach, Linda Wordeman, Duane A. Compton
Dartmouth Scholarship
The human genome has three unique genes coding for kinesin-13 proteins called Kif2a, Kif2b, and MCAK (Kif2c). Kif2a and MCAK have documented roles in mitosis, but the function of Kif2b has not been defined. Here, we show that Kif2b is expressed at very low levels in cultured cells and that GFP-Kif2b localizes predominately to centrosomes and midbodies, but also to spindle microtubules and transiently to kinetochores. Kif2b-deficient cells assemble monopolar or disorganized spindles. Chromosomes in Kif2b-deficient cells show typical kinetochore-microtubule attachments, but the velocity of movement is reduced ∼80% compared with control cells. Some Kif2b-deficient cells attempt anaphase, but the …
Detecting Agency From The Biological Motion Of Veridical Vs Animated Agents, Raymond A. Mar, William M. Kelley, Todd F. Heatherton, C. Neil Macrae
Detecting Agency From The Biological Motion Of Veridical Vs Animated Agents, Raymond A. Mar, William M. Kelley, Todd F. Heatherton, C. Neil Macrae
Dartmouth Scholarship
The ability to detect agency is fundamental for understanding the social world. Underlying this capacity are neural circuits that respond to patterns of intentional biological motion in the superior temporal sulcus and temporoparietal junction. Here we show that the brain's blood oxygenation level dependent (BOLD) response to such motion is modulated by the representation of the actor. Dynamic social interactions were portrayed by either live-action agents or computer-animated agents, enacting the exact same patterns of biological motion. Using an event-related design, we found that the BOLD response associated with the perception and interpretation of agency was greater when identical physical …