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The Role Of Mdm2 In Dna Damage Signaling, Stanley Tam
The Role Of Mdm2 In Dna Damage Signaling, Stanley Tam
Theses and Dissertations
The overexpression of the oncogene MDM2 is common in a variety of human cancers. MDM2 overexpression is known to increase genome instability in cells by delaying DNA double strand break repair and γH2AX levels. This study explores the knockdown of MDM2 and how it may affect DNA damage signaling.