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Physical Activity, Cardiorespiratory Fitness And All-Cause Mortality, Jorin Dane Larsen
Physical Activity, Cardiorespiratory Fitness And All-Cause Mortality, Jorin Dane Larsen
Theses and Dissertations
Introduction Both elevated levels of physical activity (PA) and high cardiorespiratory fitness (CRF) are associated with a decreased risk of all-cause mortality. The degree to which an individual's PA level and CRF status interact to influence mortality is not currently fully understood. This study investigated whether PA and CRF were independently related to all-cause mortality, and to what degree PA was associated with improved mortality risk in individuals with low CRF. Methods This is a prospective cohort study using health assessments on individuals gathered between 1975 and 2002. Health assessment data were matched with the National Death Registry to assess …
Conservation And Management Of Greater Sage-Grouse In Strawberry Valley: Quantifying Influences On A Traditional Capture Method And Long-Term Trends In Clutch Size, Janae Radke
Theses and Dissertations
The greater sage-grouse (Centrocercus urophasianus) is a species of conservation concern that has undergone serious declines in the last century. The Strawberry Valley sage grouse population in Utah underwent such a decline from an estimated 3,500 sage grouse in the 1930s to 150 sage grouse in the early 2000s. This decline initiated a long-term conservation and monitoring project in Strawberry Valley with the goal of preserving the sage grouse population. As part of this ongoing conservation project, we investigated factors that impact the success of capturing sage grouse using the night-lighting method (Chapter 1). We found that capture success is …
The Role Of Caloric Intake On Achilles Tendon Health In Pre-Professional Ballet Dancers, Annie G. Smedley
The Role Of Caloric Intake On Achilles Tendon Health In Pre-Professional Ballet Dancers, Annie G. Smedley
Theses and Dissertations
Background: Achilles tendinopathy is a common and debilitating condition among female ballet dancers due to the large repetitive loading forces placed on their Achilles tendons during rehearsals and performances. Tendon health problems in females are exacerbated by a lack of understanding about how energy availability influences tendons. Ballet dancers, as aesthetic athletes, are vulnerable to low energy availability and can enter a spectrum disorder, relative energy deficiency in sport, that consists of low energy availability (with or without disordered eating), menstrual cycle dysfunction, and low bone mineral density (BMD). Aims: 1) To investigate the relationship between insufficient caloric intake and …
Exploring Mesolimbic Circuitry Modulation By Opiates, Interleukin-10, And Psychostimulants, Joakim W. Ronström
Exploring Mesolimbic Circuitry Modulation By Opiates, Interleukin-10, And Psychostimulants, Joakim W. Ronström
Theses and Dissertations
The mesolimbic dopamine (DA) system originates in the ventral tegmental area (VTA) and projects to the nucleus accumbens (NAc) and other areas including the basolateral amygdala (BLA), prefrontal cortex, and the hippocampus. Drug use induces reward and leads to dysregulation in these brain areas and eventually to substance use disorders (SUDs). Chapter 1 introduces the mesolimbic DA system and its relationship to drug use and their relevance to each chapter. Chapter 2 explores opioid effects on BLA circuitry which is known to play a role in the emotional response including anxiety and stress in SUDs. We showed that morphine induced …
Characterization Of Cellular Metabolism Regulation By The Transcription Factor Centromere Binding Factor 1 (Cbf1), Spencer Ellsworth
Characterization Of Cellular Metabolism Regulation By The Transcription Factor Centromere Binding Factor 1 (Cbf1), Spencer Ellsworth
Theses and Dissertations
Centromere binding factor 1 (Cbf1) is a transcription factor that controls the transcription of many genes involved in cellular respiration and lipid biogenesis and, as such, has been associated with hypolipidemia in humans. It is a known substrate for PAS kinase, which phosphorylates Cbf1 and alters its activity. Our hypothesis is that this phosphorylation affects the genes it regulates and the DNA motifs it binds to, perhaps due to different transcription complexes being formed. In this study, we conduct a chromatin immunoprecipitation in Saccharomyces cerevisiae to determine what genes and DNA motifs Cbf1 binds to in its wild type versus …
The Effects Of Diesel Exhaust Particle Exposure On Adipos Mitochondrial Bioenergetics And Inflammation, Cali Elizabeth Warren
The Effects Of Diesel Exhaust Particle Exposure On Adipos Mitochondrial Bioenergetics And Inflammation, Cali Elizabeth Warren
Theses and Dissertations
Fine particulate matter (PM2.5) constitutes a significant component of ambient air pollution that has been implicated in the pathogenesis of metabolic disorders, including insulin resistance and type 2 diabetes. Among PM2.5 constituents, diesel exhaust particles (DEP) are prevalent particulates that infiltrate the bloodstream to drive systemic pathologies. The purpose of this study was to characterize the metabolic response of adipose tissue to DEP. We aimed to provide a comprehensive understanding by exploring mitochondrial bioenergetics, characterizing the inflammatory marker profile, including adipokines, and conducting a detailed histological analysis of adipocytes to provide valuable insights to the evolving understanding of the intricate …
Stacking And Intersecting Nutrient 4rs On Potato, Samuel Hamilton Stapley
Stacking And Intersecting Nutrient 4rs On Potato, Samuel Hamilton Stapley
Theses and Dissertations
The 4Rs of nutrient management is a global agronomic initiative with an aim to improve the sustainability of major cropping systems and the environment. The objective for this project is to evaluate individual and stacked 4R management practices and how they intersect. A field trial near Grace, Idaho was conducted on potato (Solanum tuberosum L.) in 2020 and 2023. Nitrogen (N) fertilizer treatments included all combinations of two sources [urea or polymer coated urea (PCU)], two rates (82 or 100% of the recommended rate), and/or two timing/placements (all applied at emergence or 84% at emergence + 16% fertigation simulation) compared …
Effect Of Timing Of Energy Intake On Blood Glucose And Body Composition In Women With Overweight Or Class One Obesity, Michael Wade Smith
Effect Of Timing Of Energy Intake On Blood Glucose And Body Composition In Women With Overweight Or Class One Obesity, Michael Wade Smith
Theses and Dissertations
Overweight and obesity has increased in the U.S. Unfortunately, this increases the risk of metabolic dysfunction, such as diabetes. Meal timing has recently shown promise as viable options to minimize the risk of overweight or obesity and metabolic dysfunction. The primary purpose of this study, therefore, was to investigate the effect of timing of energy intake on blood glucose in females with overweight or class one obesity (BMI=27-35 kg/m2). This study utilized crossover design with two conditions counterbalanced in random order. Participants completed two 2-week 1500kcal dietary interventions: 1) a big breakfast diet or BB (50% of energy intake between …
Characterizing Stress Granule Regulation By Pas Kinase, Ataxin-2 And Ptc6 And Investigating The Lifespan Of Covid-19 Virus On Currency, Colleen R. Newey
Characterizing Stress Granule Regulation By Pas Kinase, Ataxin-2 And Ptc6 And Investigating The Lifespan Of Covid-19 Virus On Currency, Colleen R. Newey
Theses and Dissertations
The protein Ataxin-2 is a known positive regulator of stress granules in humans, mice and yeast (known as yeast PBP1). Due to the role that stress granules play in diseases including Amyotrophic Lateral Sclerosis (ALS) and cancer, this thesis investigates the role of Ataxin-2 and its protein binding partners in stress granule development and its effects on various metabolic phenotypes of the cell. PAS kinase is a sensory protein kinase, conserved from yeast to man, which regulates respiration and lipid biosynthesis. Our lab discovered that PAS kinase phosphorylates and activates Ataxin-2 in yeast, and that PAS kinase overexpression enhances localization …
Use Of Microcalorimetry To Evaluate Hardening Reactions In Protein Bars During Accelerated Storage, Tiffany Rose Spackman
Use Of Microcalorimetry To Evaluate Hardening Reactions In Protein Bars During Accelerated Storage, Tiffany Rose Spackman
Theses and Dissertations
Protein bars have become a popular option among consumers to increase protein content in their diets. Since there is a large market for protein bars, many factors must be considered when creating a protein bar that both satisfies consumers and has a long shelf-life. Hardening and textural changes in protein bars are some of the most common modes of shelf-life failure in this product category. When the typical product creation timeline from formulation to launch can be as short as 3-6 months and with added pressure from executives to quickly launch another new product afterwards, product development scientists simply do …
Soil Health In American Sports Fields, Miria C. Barnes
Soil Health In American Sports Fields, Miria C. Barnes
Theses and Dissertations
Healthy soils are essential for sustaining the world's ecosystems and maintaining human lifestyles. The adoption of biological, chemical, and physical analyses to assess soil health is a relatively new concept with a paucity of scientific work assessing how these metrics are affected by field management in urban systems Soil samples (n = 110) were collected from a diverse range of sports fields and, for comparative purposes, golf courses, farm fields, non-sport urban, undisturbed forest, and non-vegetated sandy soils. The samples were then analyzed using biological, chemical, and physical metrics to determine if there were significant differences between sport/golf venues and …
Novel Fire And Herbivory Regime Impacts On Forest Regeneration And Plant Community Assembly, Devri A. Tanner
Novel Fire And Herbivory Regime Impacts On Forest Regeneration And Plant Community Assembly, Devri A. Tanner
Theses and Dissertations
Human activities are increasing the occurrence of megafires that have the potential to alter the ecology of forest ecosystems. The objective of this study was to understand the impact of a 610 km2 megafire on patterns of forest regeneration and herbivory of three forest types (aspen/fir, oak/maple, and pinyon/juniper) within the burn scar. Sapling density, meristem removal, and height were measured across a transect network spanning the area of the burn scar over three years from 2019-2021. The network consisted of 17 burned/unburned transect pairs in adjacent burned/unburned forest stands (6 aspen/fir, 5 oak/maple, and 6 pinyon/juniper). Species that regenerated …
Rage In Chronic Pulmonary Inflammation And Obstetric Complications, Katrina Lynn Curtis
Rage In Chronic Pulmonary Inflammation And Obstetric Complications, Katrina Lynn Curtis
Theses and Dissertations
The receptor for advanced glycation end-products (RAGE) is a transmembrane cell surface protein of the immunoglobulin superfamily that acts as part of both the innate and adaptive immune system. RAGE is highly expressed in lung tissue and is therefore of interest in the pulmonary immune response. Specifically, RAGE mediates several cell-signaling responses such as inflammation and apoptosis. This work sought to elucidate the role of RAGE in the setting of chronic pulmonary irritation such as that found in long-term exposure to secondhand smoke (SHS). This irritation has several shared characteristics with lung diseases such as chronic obstructive pulmonary disease (COPD) …
Elucidating The Architecture Of The Tclijn Complex That Converts Cysteine To Thiazoles In The Biosynthesis Of Micrococcin, Diana G. Calvopina Chavez
Elucidating The Architecture Of The Tclijn Complex That Converts Cysteine To Thiazoles In The Biosynthesis Of Micrococcin, Diana G. Calvopina Chavez
Theses and Dissertations
Thiopeptides are a family of antimicrobial peptides that are characterized for having sulfur-containing heterocycles, and for being highly post-translationally modified. Numerous thiopeptides have been identified; almost all of which inhibit protein synthesis in gram-positive bacteria. These intrinsic antimicrobial properties make thiopeptides promising candidates for the development of new antibiotics. The antimicrobial peptide micrococcin is a thiopeptide that is synthesized by the ribosome and undergoes several post-translational modifications (PTMs). Micrococcin is formed from a precursor peptide, TclE. TclE comprises an N-terminal leader (35-AA) that is crucial for recognition of the PTM machinery, alongside a C-terminal core sequence (14-AA) that undergoes multiple …
Manipulating And Assaying Chromatin Architecture Around Enhancer Elements In Vivo, John Lawrence Carter
Manipulating And Assaying Chromatin Architecture Around Enhancer Elements In Vivo, John Lawrence Carter
Theses and Dissertations
There are about 20,000 genes in the human genome. The lowly nematode worm, C. elegans, has about the same number of genes. How could two organisms that are so different arise from a similar number of genes? The answer is epigenetics, or the factors that help control when and where genes are expressed. There are many layers that comprise the epigenetic control of genes. One of which is the structure or architecture of chromatin. Chromatin is a complex of DNA and proteins. Histone proteins with DNA wrapped around them form the fundamental component of chromatin, the nucleosome. Chromatin exists in …
Cell Of Origin Identification Using Methylation Signatures From Seminal Cell-Free Dna And Heterogenous Cellular Mixtures, Ryan Barney
Theses and Dissertations
Infertility is an issue for approximately 12% of couples attempting to have a child. Of this group, 50% of the cases are due to male factor infertility. There are many reasons for decreased fecundity in men, but there remains 10% to 15% of infertile men that are diagnosed with the most severe form of infertility, non-obstructive azoospermia (NOA). A diagnosis of NOA implies the lack of sperm cells in the ejaculate with no physiological reason. The current diagnostic test and treatment consist of microscopic examination of seminal fluid and a biopsy to extract any viable sperm from the testis. This …
Changes In Rna Expression Of Hut78 Cells Resulting From The Hiv-1 Viral Protein R R77q Mutation, Joshua S. Ramsey
Changes In Rna Expression Of Hut78 Cells Resulting From The Hiv-1 Viral Protein R R77q Mutation, Joshua S. Ramsey
Theses and Dissertations
Human immunodeficiency virus type 1 (HIV-1) is the causative virus for acquired immunodeficiency syndrome (AIDS). AIDS is characterized by chronic inflammation and reduction of CD4+ T-cells in the blood. This leads to the patient becoming immunocompromised and much more susceptible to disease in general. Different phenotypes in the progression of AIDS have been observed in patients in either progressing to AIDS faster as a Rapid Progressor (RP), or slower as a Long-Term Non-Progressor (LTNP). Researching elements that result in the LTNP phenotype is of interest as it has the potential to offer alternative treatments and therapies to those suffering from …
"The Trees Act Not As Individuals"--Learning To See The Whole Picture In Biology Education And Remote Sensing Research, Rebeka A.F. Greenall
"The Trees Act Not As Individuals"--Learning To See The Whole Picture In Biology Education And Remote Sensing Research, Rebeka A.F. Greenall
Theses and Dissertations
To increase equity and inclusion for underserved and excluded Indigenous students, we must make efforts to mitigate the unique barriers they face. As their knowledge systems have been historically excluded and erased in Western science, we begin by reviewing the literature on the inclusion of Traditional Ecological Knowledge (TEK) in biology education and describe best practices. Next, to better understand how Native Hawaiian and other Pacific Islander (NHPI) students integrate into the scientific community, we used Social Influence Theory as a framework to measure NHPI student science identity, self-efficacy, alignment with science values, and belonging. We also investigated how students …
Exploring The Role Of Salt-Tolerant Halomonas Inoculant In Altering Plant Gene Expression To Improve Salt Tolerance In Alfalfa., Ashley Kay Miller
Exploring The Role Of Salt-Tolerant Halomonas Inoculant In Altering Plant Gene Expression To Improve Salt Tolerance In Alfalfa., Ashley Kay Miller
Theses and Dissertations
Soil salinity is an increasing problem facing agriculture in many parts of the world. Climate change and irrigation practices have led to decreased yields of large areas of farmland due to increased salt levels in the soil. Irrigation introduces salts to the soil that with time accumulate and threaten crop yield. In arid climates like Utah, the practice of irrigation is especially threatening to salt-sensitive crops including alfalfa (Medicago sativa). Plants that have tolerance to salt are needed to feed livestock and the world's population. One approach to address this problem is to introduce genes encoding salt tolerance into the …
An Assessment Of Cattle Traffic On, And Seed Dispersion Patterns Of, Sclerocactus Wrightiae, David D. Lariviere
An Assessment Of Cattle Traffic On, And Seed Dispersion Patterns Of, Sclerocactus Wrightiae, David D. Lariviere
Theses and Dissertations
Cattle grazing has been a historic use of rangelands in Utah since Pioneer settlement in the mid 1800's. Wright fishhook cactus is a small globose cactus endemic to an area of 280,000 ha in south-central Utah and was listed as endangered in October of 1979, by the U.S. Fish and Wildlife Service (USFWS). By 2010, concerns were expressed that soil compaction in proximity to the cactus posed a threat to this species, though there was no empirical data to support such concern. In order to assess the impact of cattle traffic on Wright fishhook cactus, we used an imprint device …
Loading Force In Recreational Runners And Its Effect On Achilles Tendon Biomechanical Properties, Joshua K. Sponbeck
Loading Force In Recreational Runners And Its Effect On Achilles Tendon Biomechanical Properties, Joshua K. Sponbeck
Theses and Dissertations
Background: Achilles tendinopathy is a common debilitating running related injury. Achilles tendon loading force has been hypothesized as a contributor to Achilles tendinopathy. Loading force through the Achilles tendon during running is impacted by many factors such as footwear and foot strike pattern. Achilles tendon biomechanical (Achilles tendon cross-sectional area, thickness, echogenicity, stiffness, and T2*) responses to loading forces are variable and measurable in vivo. These responses impact the physiologic function of the tendon. Aims: 1) To evaluate baseline Achilles tendon biomechanical characteristics associated with a runner's habitual foot strike pattern. 2) To evaluate single running bout Achilles tendon biomechanical …
The Effects Of Pain Levels On Static And Dynamic Postural Control And Visual Reliance In Chronic Ankle Instability Individuals, Minsub Oh
Theses and Dissertations
Context: Chronic ankle instability (CAI) individuals experience residual symptoms including pain, swelling, ankle instability, etc. A small majority of CAI individuals report ankle pain during daily or physical activity. Despite the known negative effects of chronic pain on neuromuscular control, there is a paucity of research exploring the specific impact of chronic pain mechanisms on altered neuromuscular control in CAI individuals. Purpose: The purpose of this study was to identify the effects of pain levels on static and dynamic postural control and visual reliance in CAI individuals. Methods: A total of 60 participants were recruited, consisting of 20 CAI individuals …
The Effects Of Ketones On Brain Metabolism And Cognition, Erin Reiko Saito
The Effects Of Ketones On Brain Metabolism And Cognition, Erin Reiko Saito
Theses and Dissertations
The brain is one of the most energetically demanding organs within the human body and is cognitively susceptible to energetic deficits such that the rise in obesity, insulin resistance, and Alzheimer’s disease in recent decades pose a substantial threat to cognitive longevity. The therapeutic efficacy of ketones are well-established in epilepsy and are currently being applied to other disease states. Alzheimer’s disease is characterized by impairments in brain glucose uptake and metabolism in regions relevant to learning, memory, and cognition that progress with the disease. While brain glucose uptake is impaired, ketone uptake is unaltered, potentially enabling ketones to fuel …
Does Chronic Low Back Pain Influence Breathing Mechanics And Diaphragm Positioning? A Pilot Study, Lindsey Wensel
Does Chronic Low Back Pain Influence Breathing Mechanics And Diaphragm Positioning? A Pilot Study, Lindsey Wensel
Theses and Dissertations
Background and objective: Chronic low back pain (CLBP) is a complex musculoskeletal condition and often the source of the pain is not clear. A correlation has been found to exist between incidences of low back pain (LBP) and those with respiratory diseases such as COPD. This could give reason to believe that the sequence of events could be reversed, and LBP could elicit changes in respiratory function. The purpose of this study is to investigate if CLBP has an influence on breathing mechanics and the positioning of the diaphragm in the trunk. Methods: Volunteers were recruited between the ages of …
Variability Among Individual Male Runners Influences Cumulative Loading More Than Foot Strike Type, Tamarie Trotter
Variability Among Individual Male Runners Influences Cumulative Loading More Than Foot Strike Type, Tamarie Trotter
Theses and Dissertations
Foot strike type affects running mechanics and may influence overuse injury occurrence. Measuring the interaction between cumulative load and foot strike type may provide additional information that could eventually help with understanding injury mechanisms. The purpose of this study was to determine how foot strike type affects cumulative loading in runners, and to determine if individual metrics change throughout a 5-kilometer sub-maximal run. 30 participants ran on an instrumented treadmill for 5 km at 3.15 m/s with their preferred foot strike type (14 rearfoot strike, 16 non-rearfoot strike). Stride rate, foot strike angle, loading rate, per stride and per km …
Improving Restoration Success Of Winterfat: Influences Of Hydrophobic Seed Coatings And Planting Depth On Seedling Emergence, Kyle Andrew Cook
Improving Restoration Success Of Winterfat: Influences Of Hydrophobic Seed Coatings And Planting Depth On Seedling Emergence, Kyle Andrew Cook
Theses and Dissertations
In western North America, winterfat (Krascheninnikovia lanata (Pursh) A. Meeuse & Smit) is a valuable protein-rich subshrub whose restoration has been limited by poor seed flowability and low rates of seedling establishment. Seed flowability can be limited by a dense covering of hairs on winterfat fruits that can cause them to clog in mechanized equipment. Seedling establishment can be limited by premature germination of fall-sown seeds that can cause over-winter seedling mortality from freezing, pathogen attack, and winter drought. Seed coatings may provide a way to overcome both of these barriers to winterfat restoration. Coatings can compress hairs against the …
Assessing The Role Of Hybridization In The Evolution Of Two Common Lineages Of Lichen-Forming Fungi, Rachel Keuler
Assessing The Role Of Hybridization In The Evolution Of Two Common Lineages Of Lichen-Forming Fungi, Rachel Keuler
Theses and Dissertations
Once thought to be an evolutionary dead-end, hybridization is now being detected in genomes across kingdoms, perhaps even playing an integral role in evolution. In chapter 1, I investigated the potential influences of hybridization on the evolution of a group of vagrant, asexual species in the Rhizoplaca melanophthalma species group. I sequenced the mitochondrial and nuclear genomes of 55 specimens and found well-supported nuclear phylogenies of both datasets. There were, however, multiple instances of discordance between the mitochondrial and nuclear trees, which can be caused by hybridization. PhyloNet and ABBA-BABA also detected widespread hybridization among this group. In chapter 2, …
Superabsorbent Polymer Use In Rangeland Restoration, Shannon V. Nelson
Superabsorbent Polymer Use In Rangeland Restoration, Shannon V. Nelson
Theses and Dissertations
Soil moisture deficits often hinder rangeland revegetation efforts. Due to sheer numbers and germination timing, invasive annual species can easily outcompete those of desired seeded species for resources, including water. One way to increase seedling establishment may be to increase the amount of water available to seeded species. Superabsorbent polymers (SAPs) can absorb and release hundreds of times their weight in water and slowly release it. Concentrated SAP bands at or near seedling rooting depth may act as a soil water reservoir for germinating seedlings and increase rangeland seedling establishment. The objective of these studies was to evaluate the effect …
Migration Of Elk (Cervus Canadensis) And Barriers To Movement, Levi Watkins
Migration Of Elk (Cervus Canadensis) And Barriers To Movement, Levi Watkins
Theses and Dissertations
Movement patterns of animals are varied, complex, and can be influenced by environmental and anthropogenic factors. One form of animal movement, migration, is influenced by environmental factors that alter the timing, duration, intensity, and likelihood of migration. Additionally, features of the landscape, both natural and anthropogenic, can alter how animals move through their seasonal and home ranges. Movement patterns can be impeded or prevented by features such as railroads, rivers, and roads. Here we explore characteristics of elk (Cervus canadensis) migration by evaluating the strategies of migration exhibited and the factors that influence migration of elk in central and eastern …
Overcoming Barriers To Native Species Restoration Using Gibberellic Acid And Fungicide Seed Coatings, Amber Jo Johnson
Overcoming Barriers To Native Species Restoration Using Gibberellic Acid And Fungicide Seed Coatings, Amber Jo Johnson
Theses and Dissertations
Many barriers can limit restoration success. In the first chapter of this thesis, the barrier of strong seed dormancy is addressed. While dormancy benefits the species' long-term survival, it can present a challenge within a restoration scenario where rapid establishment is required. Soaking seeds in gibberellic acid (GA3) can overcome dormancy. An easier and potentially more effective method to apply this hormone is to coat seeds with a GA3-impregnated polymer, which provides a slow release of the hormone. Seed dormancy can also be mitigated by creating a favorable microsite with increased soil moisture. We compared the emergence and establishment of …