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Presenilin E318g Variant And Alzheimer’S Disease Risk: The Cache Country Study, Ariel Hippen, John Kauwe

Journal of Undergraduate Research

Alzheimer’s disease is the leading cause of dementia in the elderly and the third most common cause of death in the United States. A vast number of genes regulate Alzheimer’s disease, including Presenilin 1 (PSEN1). It is possible that novel variants in the PSEN1 gene have an effect on Alzheimer’s disease status. A recent study suggested that one of these variants, PSEN1 E318G, significantly affects Alzheimer’s disease status in a large case-control dataset, particularly in connection with the APOEε4 allele [1].