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An Amino-Terminal Fragment Of Apolipoprotein E4 Leads To Behavioral Deficits, Increased Phf-1 Immunoreactivity, And Mortality In Zebrafish, Madyson M. Mccarthy, Makenna J. Hardy, Saylor E. Leising, Alex M. Lafollette, Erica S. Stewart, Amelia S. Cogan, Tanya Sanghal, Katie Matteo, Jonathon C. Reeck, Julia T. Oxford, Troy T. Rohn

Biology Faculty Publications and Presentations

Although the increased risk of developing sporadic Alzheimer’s disease (AD) associated with the inheritance of the apolipoprotein E4 (APOE4) allele is well characterized, the molecular underpinnings of how ApoE4 imparts risk remains unknown. Enhanced proteolysis of the ApoE4 protein with a toxic-gain of function has been suggested and a 17 kDa amino-terminal ApoE4 fragment (nApoE4_1-151) has been identified in post-mortem human AD frontal cortex sections. Recently, we demonstrated in vitro, exogenous treatment of nApoE4_1-151 in BV2 microglial cells leads to uptake, trafficking to the nucleus and increased expression of genes associated with cell toxicity …

Nutrient Recovery From Wastewater By A Consortium Of Algae Species For Biofuel Production, Edgardo Ayala

Boise State University Theses and Dissertations

Current energy sources are predominantly petroleum-based and their use increases greenhouse gas (GHG) emissions. As the global population grows, and along with it the demand for energy, there is a need to further develop renewable energy sources to avoid the effects of increasing atmospheric CO₂ concentrations on the climate. Biofuels, a renewable energy source, have gained significant interest as a replacement for petroleum-based fuels due to their environmental benefits and carbon neutrality. Biofuels are expected to make up 9.0% of the total fuel consumption in the U.S. by 2040, up from 7.3% in 2019 [1]. Currently, terrestrial crop-based biofuels …

Anticipating The Impacts Of The Social, Political, And Biophysical Landscape On Long-Term Connectivity For Reintroduced Plains Bison, Jamie Ann Faselt

Boise State University Theses and Dissertations

Intense anthropogenic pressures on the natural environment have created the need for implementing strategies that promote or restore habitat connectivity. The ability for animals to move between habitat patches allows animals to find mates, access resources, and shift their range in response to the changing climate and ensures that ecological and evolutionary processes persist. Connectivity conservation typically focuses on biophysical barriers to animal movement, but for many species reintroductions, establishing and maintaining connectivity often requires overcoming both ecological and socio-political barriers. Despite the need to navigate complex socio-political landscapes to implement connectivity conservation plans, datasets depicting those conditions are rarely …

The Influence Of Visitors, Habitat, And Methodology On Mexican Spotted Owl (Strik Occidentalis Lucida) Occupancy And Detection In A Remote Canyon Environment, Kirsten Fuller

Boise State University Theses and Dissertations

National Parks across America play an important role in protecting natural resources and providing access to recreation for visitors. However, these goals may come into conflict as visitation rates rise. Grand Canyon National Park in Northern Arizona is one of the most highly visited parks in the United States, with over 6 million visitors a year. Backcountry hiking and camping are popular activities in the park, and many highly visited hiking trails and campgrounds overlap with known breeding areas of a threatened species, Mexican Spotted Owl. In this thesis, I explore the intersection of recreation and wildlife conservation at this …

Applied Studies Of Raptor Sensory Ecology Are Rare, Christopher J.W. Mcclure, Simon Potier, Jesse R. Barber

Biology Faculty Publications and Presentations

Light and noise often act as pollutants, but can also be used as tools for managing wildlife (e.g., sensory deterrents). Given that raptors are among the most threatened groups of birds, we expected there to be a moderate amount of applied research on their sensory ecology. We searched Web of Science and Google Scholar to quantify and classify the research that has been conducted on the applied sensory ecology of raptors. Of 32 studies assessing the effects of sensory pollution on raptors, we found that 10 studies examined effects of light pollution and 24 studies examined effects of noise pollution. …

Dna Origami Scaffold Development For Digital Nucleic Acid Memory, Sarah Elizabeth Kobernat

Boise State University Theses and Dissertations

Recently, DNA nanotechnology has emerged as a promising and rapidly expanding method to utilize nucleic acids as a nanoscale building material. DNA origami is a major structural application of DNA nanotechnology, using DNA to construct two- and three-dimensional shapes. These structures have been employed for a variety of uses including DNA data storage. DNA is a promising material to address the impending shortage of silicon-based storage as data demands increase. There are many sequence-based methods of data storage, but digit Nucleic Acid Memory (dNAM) uses DNA origami as a breadboard and is read by super-resolution microscopy instead. dNAM uses DNA …

The Effects Of Mental Training On Acute Psychophysiological Stress Responses In Endurance Athletes, Shelanda Antonia Maria Kujala

Boise State University Theses and Dissertations

Introduction: In sports, pre-competition stress responses can influence performance. Mental skills training is a strategy used to successfully mitigate stress responses and positively impact performance. Psychological (e.g., anxiety) and physiological (e.g., cortisol) stress responses are not often measured in a single study, providing an incomplete picture of athlete experiences. When researchers have measured these constructs together, studies have excluded endurance athletes and ways to effectively buffer stress responses. Purpose: The current study had two aims. 1. How will athlete’s perceptions of stress and physiological markers of stress be related to each other? 2. How will athlete’s perceptions of stress and …

Structure, Function, And Immunogenic Applications Of Ab5-Type Adp-Ribosylating Bacterial Toxins, Elise Marie Overgaard

Boise State University Theses and Dissertations

Bacterial mono-ADP-ribosyltransferases (ARTs) catalyze the singular transfer of an ADP-ribose moiety from an NAD+ molecule onto a target molecule. ARTs contain an ancient and highly conserved tertiary structure and have a wide variety of intracellular targets and effects. Some, but not all, bacterial ARTs have an AB₅-type multimeric structure consisting of an enzymatically active subunit non-covalently situated atop of a non-toxic pentamer. The active, or A, subunit of AB₅-type toxins has a catalytic action that contributes to bacterial pathogenicity, and it is sometimes, but not always, an ART. ArtAB is an ART with AB₅-type …

Modulation Of Alpha-Crystallin-Membrane Association By Phospholipid Acyl Chain Length And Degree Of Unsaturation, Geraline Trossi-Torres

Boise State University Theses and Dissertations

Cataract is the leading cause of blindness worldwide. The only treatment for cataracts is the surgical removal of the cataractous lens and the replacement of an intraocular lens. With less availability of treatment and low income, the visual damage caused by cataracts can go untreated. The cataract may develop again after surgery, such as posterior capsule opacification. With age and cataracts, α-crystallin, a significant protein of the mammalian eye lens, is progressively associated with the eye lens membrane. The primary association sites of α-crystallin with the membranes are phospholipids. However, it is unclear if phospholipids’ acyl chain length and degree …

Tibial Compression During Activities Of Daily Living In Young And Older Adults, Elijah Miles Walker

Boise State University Theses and Dissertations

Introduction: Stress fracture, particularly in the tibia, is a growing concern among older adults (greater than 65 years). Older adults may have inherent stress fracture risk from ageing-related changes to their musculoskeletal system. Specifically, older adults reduced ankle neuromuscular function may impair their ability to attenuate repetitive compressive forces experienced during daily locomotor tasks and increase the likelihood of suffering bone damage from decreased bone tissue elasticity. Yet, it is currently unknown if older adults exhibit greater tibial compression than their younger counterparts during locomotor tasks. Purpose: This study sought to quantify tibial compression for older and younger adults when …

Bayesian Models For Spatially Explicit Interactions Between Neighbouring Plants, Cristina Barber, Andrii Zaiats, Cara Applestein, Lisa Rosenthal, T. Trevor Caughlin

Biology Faculty Publications and Presentations

1. Interactions between neighbouring plants drive population and community dynamics in terrestrial ecosystems. Understanding these interactions is critical for both fundamental and applied ecology. Spatial approaches to model neighbour interactions are necessary, as interaction strength depends on the distance between neighbouring plants. Recent Bayesian advancements, including the Hamiltonian Monte Carlo algorithm, offer the flexibility and speed to fit models of spatially explicit neighbour interactions. We present a guide for parameterizing these models in the Stan programming language and demonstrate how Bayesian computation can assist ecological inference on plant–plant interactions.

2. Modelling plant neighbour interactions presents several challenges for ecological modelling. First, nonlinear …

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Drone Imagery Protocols To Map Vegetation Are Transferable Between Dryland Sites Across An Elevational Gradient, Anna Roser, Josh Enterkine, Juan M. Requena-Mullor, Nancy F. Glenn, Alex R. Boehm, Marie-Anne De Graaff, Patrick E. Clark, Fred Pierson, T. Trevor Caughlin

Biology Faculty Publications and Presentations

The structure and composition of plant communities in drylands are highly variable across scales, from microsites to landscapes. Fine spatial resolution field surveys of dryland plants are essential to unravel the impact of climate change; however, traditional field data collection is challenging considering sampling efforts and costs. Unoccupied aerial systems (UAS) can alleviate this challenge by providing standardized measurements of plant community attributes with high resolution. However, given widespread heterogeneity in plant communities in drylands, and especially across environmental gradients, the transferability of UAS imagery protocols is unclear. Plant functional types (PFTs) are a classification scheme that aggregates the diversity …

Improved Computational Prediction Of Function And Structural Representation Of Self-Cleaving Ribozymes With Enhanced Parameter Selection And Library Design, James D. Beck

Boise State University Theses and Dissertations

Biomolecules could be engineered to solve many societal challenges, including disease diagnosis and treatment, environmental sustainability, and food security. However, our limited understanding of how mutational variants alter molecular structures and functional performance has constrained the potential of important technological advances, such as high-throughput sequencing and gene editing. Ribonuleic Acid (RNA) sequences are thought to play a central role within many of these challenges. Their continual discovery throughout all domains of life is evidence of their significant biological importance (Weinreb et al., 2016). The self-cleaving ribozyme is a class of noncoding Ribonuleic Acid (ncRNA) that has been useful for …

Spatial Models Can Improve The Experimental Design Of Field-Based Transplant Gardens By Preventing Bias Due To Neighborhood Crowding, Andrii Zaiats, Juan M. Raquena-Mullor, Matthew J. Germino, Jennifer S. Forbey, Bryce A. Richardson, T. Trevor Caughlin

Biology Faculty Publications and Presentations

Field-based transplant gardens, including common and reciprocal garden experiments, are a powerful tool for studying genetic variation and gene-by-environment interactions. These experiments assume that individuals within the garden represent independent replicates growing in a homogenous environment. Plant neighborhood interactions are pervasive across plant populations and could violate assumptions of transplant garden experiments. We demonstrate how spatially explicit models for plant–plant interactions can provide novel insights on genotypes' performance in field-transplant garden designs. We used individual-based models, based on data from a sagebrush (Artemisia spp.) common garden, to simulate the impact of spatial plant–plant interactions on between-group differences in plant …

Growth Performance And Activities Of Some Liver Enzymes In Clarias Gariepinus Burchell 1822 Juveniles Cultured In A Water Hyacinth (Eichhornia Crassipes [Mart] Solms-Laubach) Infested Media, Phebian Temitope Odufuwa

Ecology, Evolution, and Behavior

A 12-week exposure study was conducted to evaluate the growth performance and activities of some liver enzymes of African catfish (Clarias gariepinus) juveniles cultured in water hyacinth (Eichhornia crassipes) infested concrete and plastic culture media. 152 fish juveniles were introduced into two large concrete tanks (6.0 m × 5.0 m × 1.2 m) for the outdoor experiment. A tank was infested with E. crassipes plant at a density of 12.30 plants/m², while the other tank, which served as the control, contained no water hyacinth plant. For the laboratory experiment, 50 fish juveniles were stocked in duplicate into five …

Post-Fire Seed Dispersal Of A Wind-Dispersed Shrub Declined With Distance To Seed Source, Yet Had High Levels Of Unexplained Variation, Cara Applestein, T. Trevor Caughlin, Matthew J. Germino

Biology Faculty Publications and Presentations

Plant-population recovery across large disturbance areas is often seed-limited. An understanding of seed dispersal patterns is fundamental for determining natural-regeneration potential. However, forecasting seed dispersal rates across heterogeneous landscapes remains a challenge. Our objectives were to determine (i) the landscape patterning of post-disturbance seed dispersal, and underlying sources of variation and the scale at which they operate, and (ii) how the natural seed dispersal patterns relate to a seed augmentation strategy. Vertical seed trapping experiments were replicated across 2 years and five burned and/or managed landscapes in sagebrush steppe. Multi-scale sampling and hierarchical Bayesian models were used to determine the …

The Effects Of Cheatgrass Invasion On Us Great Basin Carbon Storage Depend On Interactions Between Plant Community Composition, Precipitation Seasonality, And Soil Climate Regime, Toby M. Maxwell, Matthew J. Germino

Biology Faculty Publications and Presentations

1. Annual-grass invasions are transforming desert ecosystems in ways that affect ecosystem carbon (C) balance, but previous studies do not agree on the pattern, magnitude and direction of changes. A recent meta-analysis of 41 articles and 386 sites concludes that invasion by annual grasses such as cheatgrass (Bromus tectorum L) reduces C in biomass across the Great Basin (Nagy et al., 2021). Reanalysis reveals that whether cheatgrass affects biomass C stocks is not generalizable, but rather depends on the considerable variation in climate across the subject sites. Our analysis suggests that accurate Great Basin-scale estimates of cheatgrass effects on C …

Exploring The Barriers And Facilitators To Making Healthy Physical Activity Lifestyle Choices Among Uk Bame Adults During Covid-19 Pandemic: A Study Protocol, Johnson Mbabazi, Fiona Macgregor, Mona Salman, Jeff Breckon, Edward Kunonga, Barry Tolchard, Lawrence Achilles Nnyanzi

International Journal of Physical Activity and Health

Past research has identified that individuals from BAME communities face health inequalities and report poorer outcomes from numerous health interventions. This study will explore some of the reasons with a focus on the perceptions towards physical activity in the lifestyle prevention of diseases. It will also seek to elicit a range of facilitators and barriers towards improving physical activity lifestyle choices amongst UK BAME adults, including but not limited to those in the individual, structural, environmental and social domains. Furthermore, it will consider the role of ethnicity and culture in the forming of physical activity lifestyle choices. This study was …

Meta-Analysis Reveals Challenges And Gaps For Genome-To-Phenome Research Underpinning Plant Drought Response, Anthony E. Melton, Stephanie J. Galla, Carlos Dave C. Dumaguit, John M.A. Wojahn, Stephen Novak, Marcelo Serpe, Peggy Martinez, Sven Buerki

Biology Faculty Publications and Presentations

Severe drought conditions and extreme weather events are increasing worldwide with climate change, threatening the persistence of native plant communities and ecosystems. Many studies have investigated the genomic basis of plant responses to drought. However, the extent of this research throughout the plant kingdom is unclear, particularly among species critical for the sustainability of natural ecosystems. This study aimed to broaden our understanding of genome-to-phenome (G2P) connections in drought-stressed plants and identify focal taxa for future research. Bioinformatics pipelines were developed to mine and link information from databases and abstracts from 7730 publications. This approach identified 1634 genes involved in …

Associations Of 24-Hour Movement Behaviors, Parental Academic Support, And Academic Achievement In Alaskan Adolescents, You Fu, Ryan D. Burns, Nora Constantino, Xavier Lopez, Samantha Dyer

International Journal of Physical Activity and Health

The purpose of this study was to examine the associations between meeting recommendations for 24-hour movement behaviors, parental academic support, and student academic achievement in a sample of Alaskan adolescents. Data were obtained from the 2019 Alaska Youth Risk Behavior Survey (YRBS; N = 1,897; mean age = 15.8 ± 1.3 years old). The associations between meeting recommendations for the 24-hour movement behaviors of physical activity, screen use, and sleep with high academic achievement (mostly A’s and B’s) were examined using weighted multivariable logistic regressions. Subpopulation analyses determined if associations differed by levels of parental academic support. Approximately 18.8% of …

Importance Of Flood Irrigation For Foraging Colonial Waterbirds, Colleen E. Moulton, Jay D. Carlisle, Sonya J. Knetter, Kathryn Brenner, Robert A. Cavallaro

Intermountain Bird Observatory Publications and Presentations

For a colonial‐nesting bird, like the white‐faced ibis (Plegadis chihi), the landscape surrounding the breeding colony can be important. White‐faced ibis must rely on areas outside their breeding colony for foraging, but this part of their life history has received little attention, and the management of this landscape even less so. To address this knowledge gap, we conducted road‐based driving surveys and a randomly selected, spatially balanced sample survey of agricultural fields within a 22‐km radius of the 2 largest white‐ faced ibis breeding colonies in Idaho, USA: Market Lake Wildlife Management Area and Mud Lake Wildlife Management …

Short-Eared Owl Land-Use Associations During The Breeding Season In The Western United States, Robert A. Miller, Joseph B. Buchanan, Theresa L. Pope, Jay D. Carlisle, Colleen E. Moulton, Travis L. Booms

Intermountain Bird Observatory Publications and Presentations

The Short-eared Owl (Asio flammeus) is a species of conservation concern in the western USA, with evidence for declining population sizes. Monitoring of Short-eared Owls is complicated because of their low site fidelity and nomadic movements. We recruited community-science participants to implement a multi-year survey of Short-eared Owls across eight states in the western USA, resulting in a program of sufficient temporal and spatial dimensions to overcome many of the challenges in monitoring this species. We implemented both multi-scale occupancy and colonization/extinction modeling to provide insights into land-cover use, and to identify which cover types supported higher occurrence. …

Sex Impact On Knee And Ankle Muscle Extensor Forces During Loaded Running, Kade D. Wagers, Nicholas J. Lobb, Auralea C. Fain, Kayla D. Seymore, Tyler N. Brown

Kinesiology Faculty Publications and Presentations

Background: This study determined whether the knee and ankle muscle extensor forces increase when running with a body-borne load and whether these forces differ between the sexes. Methods: Thirty-six (twenty male and sixteen female) adults had the knee and ankle extensor force quantified when running 4.0 m/s with four body-borne loads (20, 25, 30, and 35 kg). Peak normalized (BW) and unnormalized (N) extensor muscle force, relative effort, and joint angle and angular velocity at peak muscle force for both the ankle and the knee were submitted to a mixed model ANOVA. Results: Significant load by sex interactions for knee …

Drought Tolerance Of Artemisia Tridentata In Response To Herbivory And Mycorrhizal Colonization, Mathew Geisler

Boise State University Theses and Dissertations

Interactions with other organisms can affect a plant’s ability to cope with drought. The re-establishment of Artemisia tridentata, a keystone species of the sagebrush steppe, is often limited by summer drought. This study investigated the effect of two biotic factors, herbivory and symbiosis with arbuscular mycorrhizal fungi (AMF), on the drought tolerance of Artemisia tridentata ssp. wyomingensis (Wyoming big sagebrush) seedlings. For this purpose, I conducted two separate but concurrent field experiments. The herbivory experiment had three treatments: seedlings without tree protectors and seedlings within Vexar or metal-mesh tree protectors. In the mycorrhizal experiment, all seedlings were within metal-mesh …

Validation Of Non-Invasive Co2 Tolerance Field Test, Joshua T. Murphey

Boise State University Theses and Dissertations

INTRODUCTION: Breathwork, or the specific act of controlling breathing to elicit a desired outcome, is not only a potential way to improve one’s mental well-being but also to alter adaptative responses through gas exchange at the capillary level. Increasing tolerance to carbon dioxide (CO₂) has been positively correlated with improvement in athletic performance and reduction of stress and anxiety. However, there does not exist a validated non-invasive test to accurately measure one’s tolerance to CO₂. PURPOSE: The purpose of this study was to validate the only currently known CO₂ tolerance (CO₂T) field test …

Improving The Ribozyme Toolbox: From Structure-Function Insights To Synthetic Biology Applications, Jessica Michelle Roberts

Boise State University Theses and Dissertations

Self-cleaving ribozymes are a naturally occurring class of catalytically active RNA molecules which cleave their own phosphate backbone. In nature, self-cleaving ribozymes are best known for their role in processing concatamers of viral genomes into monomers during viral replication in some RNA viruses, but to a lesser degree have also been implicated in mRNA regulation and processing in bacteria and eukaryotes. In addition to their biological relevance, these RNA enzymes have been harnessed as important biomolecular tools with a variety of applications in fields such as bioengineering. Self-cleaving ribozymes are relatively small and easy to generate in the lab using …

Effects Of Aging On Patellofemoral Joint Stress During Stair Negotiation On Challenging Surfaces, Nicholas Lynn Hunt

Boise State University Theses and Dissertations

Introduction: Patellofemoral pain is an incessant lower limb musculoskeletal disorder that may be underreported in older adults. During common locomotor activities, such as when negotiating stairs, older adults (over the age of 65 years) adopt knee biomechanics reported to increase patellofemoral pain. Negotiating stairs with a challenging surface, such as uneven or slick, may place greater demand on the knee and further exacerbate joint biomechanics related to PFJ stress. Yet, it is unknown if older adults exhibit increases in patellofemoral joint (PFJ) stress when negotiating stairs with challenging surfaces. Purpose: The purpose of this study was to examine the effect …

A Comparative Study On The Construction Of Special Psychological Ability Indexes Of Curling Male Athletes, Xuelin Pang, Zhengze Zhang

International Journal of Physical Activity and Health

Curling is a sport combining skill and intelligence. Athletes should not only have proficient physical fitness, technical and tactical level, but they also need strong psychological ability. This study attempts to build a special psychological ability system for curling athletes, to provide guidance for the athlete selection and training. In this study, 13 male athletes of Heilongjiang curling team were recruited. HengChan Yin 's attention scale, Dr. Ping Ye's competitive motivation scale, XiaoChuan Yin 's excellent athlete's will quality evaluation scale, Vealey's athlete's trait self-confidence scale, Martens's sports competition state anxiety scale, LiWei Zhang's pre competition emotion scale-t scale, electronic …

The Relationship Between Physical Activity And Academic Performance Of Students, Haizhi Dai, Shuisheng Xu

International Journal of Physical Activity and Health

In China, many teachers and parents concern that physical activities take too much time of students, which would negatively influence students’ academic performance and the inescapable pressure of schools to produce students who meet academic standards. However, decreased physical activity participation due to the scarcity of exercises becomes prevalent in Chinese students. The correlation between students’ physical activity participation and academic achievement has raised increased attention. This study explored the relationship between students’ physical activity participation and academic performance from the perspective of humanities and sociology to explore a way to balance the two aspects for students. We conducted literature …

The Influence Of Tai Chi Intervention On Inhibitory Function Of African College Students, Tongtong Guo, Jian Yang

International Journal of Physical Activity and Health

Inhibitory function is the core sub-function of executive function, which is mainly aimed at inhibiting the current dominant response in the cognitive process. It is embodied in the control of preventing the activation of irrelevant information, disturbing the irrelevant information, and the dominant reaction in the process. However, little research has examined the impact of Tai Chi on inhibitory function among native African students. The major purpose of this study was to conduct an experimental study on the inhibitory function of African college students through Tai Chi intervention, and to explore the non-Tai Chi local country students’ changes in the …