Digital Commons Network^™

Tau Kinetics In Alzheimer's Disease, Daniel B. Hier, Sima Azizi, Matthew S. Thimgan, Donald C. Wunsch

Chemistry Faculty Research & Creative Works

The Cytoskeletal Protein Tau is Implicated in the Pathogenesis of Alzheimer's Disease Which is Characterized by Intra-Neuronal Neurofibrillary Tangles Containing Abnormally Phosphorylated Insoluble Tau. Levels of Soluble Tau Are Elevated in the Brain, the CSF, and the Plasma of Patients with Alzheimer's Disease. to Better Understand the Causes of These Elevated Levels of Tau, We Propose a Three-Compartment Kinetic Model (Brain, CSF, and Plasma). the Model Assumes that the Synthesis of Tau Follows Zero-Order Kinetics (Uncorrelated with Compartmental Tau Levels) and that the Release, Absorption, and Clearance of Tau is Governed by First-Order Kinetics (Linearly Related to Compartmental Tau Levels). …

Short Communication: Savanna-Forest Boundary On Mount Rinjani, Lombok Island, West Nusa Tenggara, Indonesia, Sutomo, Eddie Van Etten, Rajif Iryadi

Research outputs 2014 to 2021

© 2021, Society for Indonesian Biodiversity. All rights reserved. Sutomo, van Etten E, Iryadi R. 2020. Short communication: Savanna-forest boundary on Mount Rinjani, Lombok Island, West Nusa Tenggara, Indonesia. Biodiversitas 21: 726-731. Seasonally dry tropical forests tend to be bordered by or are mixed with savanna ecosystems. This research investigates the location and nature of forest-savanna boundary on Mt. Rinjani and hypothesizes on potential causes of such boundary formation. The field survey locations were based on MODIS burnt area data. We made 30 plots (50 x 50 m) established along transects to obtain vegetation and environment data across boundaries. For …

How Demographic Processes Shape Animal Social Networks, Daizaburo Shizuka, Allison E. Johnson

School of Biological Sciences: Faculty Publications

Invited review

Demographic processes play a key role in shaping the patterns of social relations among individuals in a population. Social network analysis is a powerful quantitative tool for assessing the social structure formed by associations between individuals. However, demographic processes are rarely accounted for in such analyses. Here, we summarize how the structure of animal social networks is shaped by the joint effects of social behavior and turnover of individuals and suggest how a deeper understanding of these processes can open new, exciting avenues for research. Death or dispersal can have the direct effect of removing an individual and …

How Do Ecological Resilience Metrics Relate To Community Stability And Collapse?, Caleb P. Roberts, Dirac L. Twidwell Jr, David G. Angeler, Craig R. Allen

Department of Agronomy and Horticulture: Faculty Publications

The concept of ecological resilience (the amount of disturbance a system can absorb before collapsing and reorganizing) holds potential for predicting community change and collapse—increasingly common issues in the Anthropocene. Yet neither the predictions nor metrics of resilience have received rigorous testing. The crossscale resilience model, a leading operationalization of resilience, proposes resilience can be quantified by the combination of diversity and redundancy of functions performed by species operating at different scales. Here, we use 48 years of sub-continental avian community data aggregated at multiple spatial scales to calculate resilience metrics derived from the cross-scale resilience model (i.e., cross-scale diversity, …

Biotime: A Database Of Biodiversity Time Series For The Anthropocene, Maria Dornelas, Laura H. Antão, Faye Moyes, Amanda E. Bates, Anne E. Magurran, Dušan Adams, Asem A. Akhmetzhanova, Ward Appeltans, José Manuel Adam, Frank P. Day

Biological Sciences Faculty Publications

Motivation: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene.

Main types of variables included: The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains …

Biotime: A Database Of Biodiversity Time Series For The Anthropocene, Maria Dornelas, Laura H. Antão, Faye Moyes, Amanda E. Bates, Anne E. Magurran, Dušan Adam, Asem A. Akhmetzhanova, Ward Appeltans, José Manuel Arcos, Haley Arnold, Narayanan Ayyappan, Gal Badihi, Andrew H. Baird, Miguel Barbosa, Tiago Egydio Barreto, Claus Bässler, Alecia Bellgrove, Jonathan Belmaker, Lisandro Benedetti-Cecchi, Brian J. Bett, Anne D. Bjorkman, Magdalena Błażewicz, Shane A. Blowes, Christopher P. Bloch, Timothy C. Bonebrake, Susan Boyd, Matt Bradford, Andrew J. Brooks, James H. Brown, Helge Bruelheide, Phaedra Budy, Fernando Carvalho, Edward Castañeda-Moya, Chaolun Allen Chen, John F. Chamblee, Tory J. Chase, Laura Siegwart Collier, Sharon K. Collinge, Richard Condit, Elisabeth J. Cooper, J Hans C. Cornelissen, Unai Cotano, Shannan Kyle Crow, Gabriella Damasceno, Claire H. Davies, Robert A. Davis, Frank P. Day, Steven Degraer, Tim S. Doherty, Timothy E. Dunn, Giselda Durigan, J. Emmett Duffy, Dor Edelist, Graham J. Edgar, Robin Elahi, Sarah C. Elmendorf, Anders Enemar, S. K. Morgan Ernest, Rubén Escribano, Marc Estiarte, Brian S. Evans, Tung-Yung Fan, Fabiano Turini Farah, Luiz Loureiro Fernandes, Fábio Z. Farneda, Alessandra Fidelis, Robert Fitt, Anna Maria Fosaa, Geraldo Antonio Daher Correa Franco, Grace E. Frank, William R. Fraser, Hernando García, Roberto Cazzolla Gatti, Or Givan, Elizabeth Gorgone-Barbosa, William A. Gould, Corinna Gries, Gary D. Grossman, Julio R. Gutierréz, Stephen Hale, Mark E. Harmon, John Harte, Gary Haskins, Donald L. Henshaw, Luise Hermanutz, Pamela Hidalgo, Pedro Higuchi, Andrew Hoey, Gert Van Hoey, Annika Hofgaard, Kristen Holeck, Robert D. Hollister, Richard Holmes, Mia Hoogenboom, Chih-Hao Hsieh, Stephen P. Hubbell, Falk Huettmann, Christine L. Huffard, Allen H. Hurlbert, Natália Macedo Ivanauskas, David Janík, Ute Jandt, Anna Jażdżewska, Tore Johannessen, Jill Johnstone, Julia Jones, Faith A. M. Jones, Jungwon Kang, Tasrif Kartawijaya, Erin C. Keeley, Douglas A. Kelt, Rebecca Kinnear, Kari Klanderud, Halvor Knutsen, Christopher C. Koenig, Alessandra R. Kortz, Kamil Král, Linda A. Kuhnz, Chao-Yang Kuo, David J. Kushner, Claire Laguionie-Marchais, Lesley T. Lancaster, Cheol Min Lee, Jonathan S. Lefcheck, Esther Lévesque, David Lightfoot, Francisco Lloret, John D. Lloyd, Adrià López-Baucells, Maite Louzao, Joshua S. Madin, Borgþór Magnússon, Shahar Malamud, Iain Matthews, Kent P. Mcfarland, Brian Mcgill, Diane Mcknight, William O. Mclarney, Jason Meador, Peter L. Meserve, Daniel J. Metcalfe, Christoph F. J. Meyer, Anders Michelsen, Nataliya Milchakova, Tom Moens, Even Moland, Jon Moore, Carolina Mathias Moreira, Jörg Müller, Grace Murphy, Isla H. Myers-Smith, Randall W. Myster, Andrew Naumov, Francis Neat, James A. Nelson, Michael Paul Nelson, Stephen F. Newton, Natalia Norden, Jeffrey C. Oliver, Esben M. Olsen, Vladimir G. Onipchenko, Krzysztof Pabis, Robert J. Pabst, Alain Paquette, Sinta Pardede, David M. Paterson, Raphaël Pélissier, Josep Peñuelas, Alejandro Pérez-Matus, Oscar Pizarro, Francesco Pomati, Eric Post, Herbert H. T. Prins, John C. Priscu, Pieter Provoost, Kathleen L. Prudic, Erkki Pulliainen, B. R. Ramesh, Olivia Mendivil Ramos, Andrew Rassweiler, Jose Eduardo Rebelo, Daniel C. Reed, Peter B. Reich, Suzanne M. Remillard, Anthony J. Richardson, J. Paul Richardson, Itai Van Rijn, Ricardo Rocha, Victor H. Rivera-Monroy, Christian Rixen, Kevin P. Robinson, Ricardo Ribeiro Rodrigues, Denise De Cerqueira Rossa-Feres, Lars Rudstam, Henry Ruhl, Catalina S. Ruz, Erica M. Sampaio, Nancy Rybicki, Andrew Rypel, Sofia Sal, Beatriz Salgado, Flavio A. M. Santos, Ana Paula Savassi-Coutinho, Sara Scanga, Jochen Schmidt, Robert Schooley, Fakhrizal Setiawan, Kwang-Tsao Shao, Gaius R. Shaver, Sally Sherman, Thomas W. Sherry, Jacek Siciński, Caya Sievers, Ana Carolina Da Silva, Fernando Rodrigues Da Silva, Fabio L. Silveira, Jasper Slingsby, Tracey Smart, Sara J. Snell, Nadejda A. Soudzilovskaia, Gabriel B. G. Souza, Flaviana Maluf Souza, Vinícius Castro Souza, Christopher D. Stallings, Rowan Stanforth, Emily H. Stanley, José Mauro Sterza, Maarten Stevens, Rick Stuart-Smith, Yzel Rondon Suarez, Sarah Supp, Jorge Yoshio Tamashiro, Sukmaraharja Tarigan, Gary P. Thiede, Simon Thorn, Anne Tolvanen, Maria Teresa Zugliani Toniato, Ørjan Totland, Robert R. Twilley, Gediminas Vaitkus, Nelson Valdivia, Martha Isabel Vallejo, Thomas J. Valone, Carl Van Colen, Jan Vanaverbeke, Fabio Venturoli, Hans M. Verheye, Marcelo Vianna, Rui P. Vieira, Tomáš Vrška, Con Quang Vu, Lien Van Vu, Robert B. Waide, Conor Waldock, Dave Watts, Sara Webb, Tomasz Wesołowski, Ethan P. White, Claire E. Widdicombe, Dustin Wilgers, Richard Williams, Stefan B. Williams, Mark Williamson, Michael R. Willig, Trevor J. Willis, Sonja Wipf, Kerry D. Woods, Eric J. Woehler, Kyle Zawada, Michael L. Zettler

Research outputs 2014 to 2021

Motivation: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene.

Main types of variables included: The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains …

Biotime: A Database Of Biodiversity Time Series For The Anthropocene, Maria Dornelas, Laura H. Antão, Faye Moyes, Amanda E. Bates, Anne E. Magurran, Dušan Adam, Asem A. Akhmetzhanova, Ward Appeltans, José M. Arcos, Christopher D. Stallings

Marine Science Faculty Publications

Motivation: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community‐led open‐source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene.

Main types of variables included: The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains …

Microbial And Co2 Responses To Water Stresses Show Decreased Productivity And Diversity Through Time, David Michael Robinson

Theses and Dissertations

Some bacterial taxa when stimulated by water additions will break dormancy, grow, and become dominant members of the community and contribute significant pulses of CO₂ associated with the rewetting event. These pulses of activity are associated with high levels of bacterial productivity in soils. (Aanderud et al. 2011) We examined the bacterial taxa that resuscitate and become metabolically active following two forms of water stress (soil drying-rewetting and freeze-thaw cycles) and we captured and measured the CO₂ emanating from those soils. Specifically, We used target metagenomics, which uses a specific gene pool within bacteria that is associated with …

Herbivory And Drought Generate Short‐Term Stochasticity And Long‐Term Stability In A Savanna Understory Community, Corinna Riginos, Lauren M. Porensky, Kari E. Veblen, Truman P. Young

Wildland Resources Faculty Publications

Rainfall and herbivory are fundamental drivers of grassland plant dynamics, yet few studies have examined long‐term interactions between these factors in an experimental setting. Understanding such interactions is important, as rainfall is becoming increasingly erratic and native wild herbivores are being replaced by livestock. Livestock grazing and episodic low rainfall are thought to interact, leading to greater community change than either factor alone. We examined patterns of change and stability in herbaceous community composition through four dry periods, or droughts, over 15 years of the Kenya Long‐term Exclosure Experiment (KLEE), which consists of six different combinations of cattle, native wild …

Estimating Taxon-Specific Population Dynamics In Diverse Microbial Communities, Benjamin J. Koch, Theresa A. Mchugh, Michaela Hayer, Egbert Schwartz, Steven J. Blazewicz, Paul Dijkstra, Natasja Van Gestel, Jane C. Marks, Rebecca L. Mau, Ember M. Morrissey, Jennifer Pett-Ridge, Bruce A. Hungate

Faculty & Staff Scholarship

Understanding how population-level dynamics contribute to ecosystem-level processes is a primary focus of ecological research and has led to important breakthroughs in the ecology of macroscopic organisms. However, the inability to measure population-specific rates, such as growth, for microbial taxa within natural assemblages has limited ecologists’ understanding of how microbial populations interact to regulate ecosystem processes. Here, we use isotope incorporation within DNA molecules to model taxon- specific population growth in the presence of 18O-labeled water. By applying this model to phylogenetic marker sequencing data collected from stable-isotope probing studies, we estimate rates of growth, mortal- ity, and turnover for …

The Effects Of Salinity On The Stratification And Nutrient Dynamics Of Inland Lakes In Southeast Michigan, Hallee Kansman

Senior Honors Theses and Projects

Temperate lakes typically turnover twice annually; however, certain factors can reduce the possibility of turnover. One of these factors may be the addition of road salt to the watershed. Road salt increases the density of water, increasing the energy needed to turnover a lake. Reduced turnover can have major effects on the nutrient dynamics of the lake. In this study, I examined seven small, deep lakes in Southeast Michigan to determine if turnover was affected by salinity. The purpose of this study was to determine whether these turnover events in TSL have changed since 2009 and how common incomplete spring …

An Investigation Of Mitochondrial Bioenergetics And The Turnover Of Succinated Proteins In The Adipocyte During Diabetes, Ross Tanis

Theses and Dissertations

We previously identified the chemical modification S-(2-succino)cysteine (2SC), which is formed when the Krebs cycle metabolite fumarate reacts with protein cysteine residues, also termed protein succination. Protein succination is increased in the adipose tissue of ob/ob and db/db mice in vivo and in 3T3-L1 adipocytes grown in high glucose in vitro. The increase in 2SC in the 3T3-L1 adipocyte occurs as a direct result of glucotoxicity and increased mitochondrial stress. We have shown that uncoupling agents, which lower mitochondrial stress, prevent the increase in succinated proteins.

In this study we examined the relationship between increased succination and mitochondrial bioenergetics in …

Soil Moisture, Fire, And Tree Community Structure, William Patrick White

Browse all Theses and Dissertations

My study was conducted to understand tree community structure and how soil moisture and fire frequency influence them. Eighteen plots were placed in the Edge of Appalachia Nature Preserve of unglaciated southern Ohio: nine within a prescribed burn site and nine control sites outside the burn. Sites were stratified in triplicate across GIS-derived integrated soil moisture index (IMI) classes. Burning was done in 1996. Overstory species dbh and sapling species were sampled 1997, 2001, and 2008. Overstory stems were located in 2009 using range finders. Stem locations were loaded into GIS using novel techniques to quantify individual stem IMI values. …

Dms Air/Sea Flux And Gas Transfer Coefficients From The North Atlantic Summertime Coccolithophore Bloom, Christa Marandino, Warren J. De Bruyn, Scott Miller, Eric S. Saltzman

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Dimethylsulfide (DMS) atmospheric and oceanic concentrations and eddy covariance air/sea fluxes were measured over the N. Atlantic Ocean during July 2007 from Iceland to Woods Hole, MA, USA. Seawater DMS levels north of 55 degrees N ranged from 3 to 17 nM, with variability related to the satellite-derived distributions of coccoliths and to a lesser extent, chlorophyll. For the most intense bloom region southwest of Iceland, DMS air/sea fluxes were as high as 300 mu mol m(-2) d(-1), larger than current model estimates. The observations imply that gas exchange coefficients in this region are significantly greater than those estimated using …

Stabel Isotope Turnover Rates And Diet-Tissue Discrimination In The Skin Of West Indian Manatees: Implcations For Evaluating Their Feeding Ecology And Habitat Use, Christy Alves

Electronic Theses and Dissertations

The West Indian manatee (Trichechus manatus) is an herbivorous marine mammal that occupies freshwater, estuarine, and marine habitats. Despite being considered endangered, relatively little is known about the feeding ecology of either of the two recognized subspecies, the Florida manatee (T.m. latirostris) and Caribbean or Antillean manatee (T.m. manatus). A better understanding of their respective feeding preferences and habitat use is essential to establish criteria on which conservation plans can be based. The present study expands on previous work on manatee feeding ecology by both assessing the application of stable isotope analysis to manatee tissue and providing critical baseline parameters …

Evidence For A General Species-Time-Area Relationship, Peter B. Adler, Ethan P. White, William K. Lauenroth, Dawn M. Kaufman, Andrew Rassweiler, James A. Rusak

Ethan P White

The species–area relationship (SAR) plays a central role in biodiversity research, and recent work has increased awareness of its temporal analogue, the species– time relationship (STR). Here we provide evidence for a general species–time–area relationship (STAR), in which species number is a function of the area and time span of sampling, as well as their interaction. For eight assemblages, ranging from lake zooplankton to desert rodents, this model outperformed a sampling-based model and two simpler models in which area and time had independent effects. In every case, the interaction term was negative, meaning that rates of species accumulation in space …

Evidence For A General Species-Time-Area Relationship, Peter B. Adler

Peter B. Adler

The species–area relationship (SAR) plays a central role in biodiversity research, and recent work has increased awareness of its temporal analogue, the species– time relationship (STR). Here we provide evidence for a general species–time–area relationship (STAR), in which species number is a function of the area and time span of sampling, as well as their interaction. For eight assemblages, ranging from lake zooplankton to desert rodents, this model outperformed a sampling-based model and two simpler models in which area and time had independent effects. In every case, the interaction term was negative, meaning that rates of species accumulation in space …

Evidence For A General Species Time Arearelationship, P. B. Adler, Ethan P. White, W. K. Lauenroth, D. M. Kaufman, A. Rassweiler, J. A. Rusak

Biology Faculty Publications

The species-area relationship (SAR) plays a central role in biodiversity research, and recent work has increased awareness of its temporal analog, the species-time relationship (STR). Here we provide evidence for a general species-time-area-relationship (STAR), in which species number is a function of the area and time span of sampling, as well as their interaction. For eight assemblages ranging from lake zooplankton to desert rodents, this model outperformed a sampling-based model and two simpler models in which area and time had independent effects. In every case the interaction term was negative, meaning that rates of species accumulation in space decreased with …

Antipredator Behavior And Physiology Determine Lestes Species Turnover Along The Pond-Permanence Gradient, Robby Stoks, Mark A. Mcpeek

Dartmouth Scholarship

Identifying key traits that shape trade-offs that restrict species to only a subset of environmental gradients is crucial to understanding and predicting species turnover. Previous field experiments have shown that larvae of Lestes damselfly species segregate along the entire gradient of pond permanence and predator presence and that differential predation risk and life history constraints together shape their distribution. Here, we report laboratory experiments that identify key differences in behavior and physiology among species that structure their distributions along this gradient. The absence of adaptive antipredator behavioral responses against large dragonfly larvae and fish of Lestes dryas, the only species …

Predators And Life Histories Shape Lestes Damselfly Assemblages Along A Freshwater Habitat Gradient, Robby Stoks, Mark A. Mcpeek

Dartmouth Scholarship

Survey data from New England showed that assemblages of Lestes damselflies are organized along the entire gradient of pond permanence and predator presence. One assemblage occupies vernal ponds lacking large dragonfly predators and fish; four are largely confined to temporary ponds that typically contain dragonfly predators; one dominates fishless permanent ponds and lakes where dragonflies are the top predators; and one dominates permanent ponds and lakes where fish are the top predators. We determined the role of life history and predation in maintaining this striking pattern by conducting a series of transplant experiments in the field and a laboratory experiment …

Predators And Life Histories Shape Lestes Damselfly Assemblages Along A Freshwater Habitat Gradient, Robby Stoks, Mark A. Mcpeek

Dartmouth Scholarship

Survey data from New England showed that assemblages of Lestes dam- selflies are organized along the entire gradient of pond permanence and predator presence. One assemblage occupies vernal ponds lacking large dragonfly predators and fish; four are largely confined to temporary ponds that typically contain dragonfly predators; one dom- inates fishless permanent ponds and lakes where dragonflies are the top predators; and one dominates permanent ponds and lakes where fish are the top predators. We determined the role of life history and predation in maintaining this striking pattern by conducting a series of transplant experiments in the field and a …

The Effect Of Nitrogen Fertilization On The Phenology Of Roots In A Barrier Island Sand Dune Community, Everett P. Weber

Biological Sciences Theses & Dissertations

Little work has been done on the phenology of root growth and senescence largely due to methodological difficulties. The application of minirhizotron technology has enabled the tracking of individual roots through an entire growing season. As a result, direct measures of turnover, root growth, and an analysis of cohorts were made. Small plots on a 36 year old dune on Hog Island, a barrier island in the Virginia Coast Reserve Long Term Ecological Research Site, were fertilized with nitrogen. Minirhizotron tubes were installed in each fertilized and control plot. Each tube was sampled monthly for nine months, March through October …

Influence Of 2,5-Hexanedione, Acrylamide, Tri-O-Tolyl Phosphate, Leptophos And Methylmercury On Endogenous Levels Of Tryptophan, Serotonin And 5-Hydroxyindoleacetic Acid And Serotonin Turnover Rates In Rat Brain, Craig H. Farr

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Several industrial and environmental chemicals cause distal and/or central neuropathy among other diverse toxic effects. Spague-Dawley derived rats were fed doses of 2,5-hexanedione, acrylamide, tri-o-tolyl phosphate, Leptophos and methylmercury via gavage. The dose levels and administration periods were established in previous experiments designed to assess clinical neuropathy using rats trained to walk on a rotorod apparatus fitted with an electrode floor. After intravenous injections of ³H-Tryptophan, whole rat brain homogenates were analyzed using liquid scintillation and spectrofluorometric techniques for levels of tryptophan, serotonin and 5-hydroxyindoleacetic acid. Serotonin turnover rates were calculated using the specific activities of tryptophan and serotonin …

Decomposition Rates Of Aspen Bole And Branch Litter, W.E. Miller

Aspen Bibliography

No abstract provided.