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Septal Infusions Of The H-Channel Blocker Zd7288 Impair Spontaneous Alternation But Not Inhibitory Avoidance, Ramata Sissoko Cisse
Septal Infusions Of The H-Channel Blocker Zd7288 Impair Spontaneous Alternation But Not Inhibitory Avoidance, Ramata Sissoko Cisse
Biology Theses
It is well established that the septo-hippocampal system is involved in memory. The medial septum is connected to the hippocampus via the fimbria fornix, which consists mostly of acetylcholine and ã-aminobutyric acid (GABA) projection neurons. The contributions of the cholinergic projection to memory have been studied extensively; whereas, the role of the GABAergic projection is not well characterized. The present experiment tested whether septal infusions of the selective H-channel blocker ZD7288 would impair spontaneous alternation (SA) and continuous multiple inhibitory avoidance (CMIA). Fifteen minutes prior to assessing SA or CMIA, different groups of male Sprague-Dawley rats were given septal infusions …