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Article Navigation Wild-Type Measles Virus Infection Upregulates Poliovirus Receptor-Related 4 And Causes Apoptosis In Brain Endothelial Cells By Induction Of Tumor Necrosis Factor-Related Apoptosis-Lnducing Ligand, Haniah Abdullah, Brenda B. Brankin, Clare Brady, Sara Louise Cosby
Article Navigation Wild-Type Measles Virus Infection Upregulates Poliovirus Receptor-Related 4 And Causes Apoptosis In Brain Endothelial Cells By Induction Of Tumor Necrosis Factor-Related Apoptosis-Lnducing Ligand, Haniah Abdullah, Brenda B. Brankin, Clare Brady, Sara Louise Cosby
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Small numbers of brain endothelial cells (BECs) are infected in children with neurologic complications of measles virus (MV) infection. This may provide a mechanism for virus entry into the central nervous system, but the mechanisms are unclear. Both in vitro culture systems and animal models are required to elucidate events in the endothelium. We compared the ability of wild-type (WT), vaccine, and rodent-adapted MV strains to infect, replicate, and induce apoptosis in human and murine brain endothelial cells (HBECs and MBECs, respectively). Mice also were infected intracerebrally. All MV stains productively infected HBECs and induced the MV receptor PVRL4. Efficient …