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Using Zebrafish As A Model System For Studying The Autism Risk Gene Adnp In Early Embryonic Development, William Theune
Using Zebrafish As A Model System For Studying The Autism Risk Gene Adnp In Early Embryonic Development, William Theune
Master's Theses
Autism Spectrum Disorders (ASD) are a group of debilitating neurodevelopmental disorders, estimated to affect 1 in 54 children. Despite the identification of many autism-risk genes, the underlying mechanisms for ASD remain unclear. One of the most common forms of ASD is associated with de novo mutations in the ADNP gene (Activity-Dependent Neuroprotector Homeobox; accounting for 0.17% of ASD individuals). Termed ADNP syndrome, this disorder is characterized by intellectual disability, facial dysmorphia, and is comorbid with multiple organ system deficits. We set out to use zebrafish as a model organism to gain mechanistic insights into ADNP function. Zebrafish have the advantage …
Effects Of Bacterial Metabolites In Conditioned Media On Colon Cancer Proliferation, Hunter Panier
Effects Of Bacterial Metabolites In Conditioned Media On Colon Cancer Proliferation, Hunter Panier
Master's Theses
Cancer is the second leading cause of death in the United States with colorectal cancer (CRC) being the third most common type. Available treatments include a combination of surgery and chemotherapy but have debilitating side effects. These also have limited effectiveness in some cases, creating the need for additional treatment options, or supplementary treatments to increase their effectiveness. This is leading scientists to consider the microbiome to fix this shortcoming. Current research is focusing on the microbiome and its interactions with certain diseases, which could lead to pro- or prebiotic therapies. This work aims to establish specific bacterial species can …