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Dna-Binding And Cellular Uptake Properties Of Pyrrole-Imidazole Polyamides, Maria J. Scuderi
Dna-Binding And Cellular Uptake Properties Of Pyrrole-Imidazole Polyamides, Maria J. Scuderi
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Pyrrole-imidazole polyamides (PAs) represent a class of synthetic ligands that bind to the minor groove of DNA through hydrogen bonds and can be programmed to recognize predetermined DNA sequences. Potential applications of these compounds include gene expression modulation, antimicrobial activity and cell imaging.
Studies conducted in our lab in collaboration with NanoVir have shown that large PAs exhibit antiviral activity against Human Papillomavirus (HPV), which is the most common sexually transmitted infectious agent in the US and the primary factor for the development of cervical cancer. PAs act against HPV by targeting the viral DNA and promoting its selective elimination …