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Impact Of Parity On Gait Biomechanics, Bekah P. Stein
Impact Of Parity On Gait Biomechanics, Bekah P. Stein
Masters Theses
Background: Symptomatic knee osteoarthritis (OA) is an incurable condition that affects nearly 50% of adults, and women are twice as likely as men to develop OA. Throughout pregnancy, women experience large changes in morphology and gait mechanics, as well as changes in joint loading. It is possible these adaptations could cause lasting changes postpartum, which may potentially contribute to initiation of OA, thereby increasing the overall risk of OA for women.
Purpose: This exploratory study looked to identify differences between lower limb gait mechanics of healthy nulliparous women and healthy parous women.
Methods: 28 healthy female participants (14 parous, 14 …
Microenvironment Regulates Fusion Of Breast Cancer Cells, Peiran Zhu
Microenvironment Regulates Fusion Of Breast Cancer Cells, Peiran Zhu
Masters Theses
Fusion of cancer cells has been observed in tumors for more than a century and is thought to contribute to tumor development and drug resistance. The low frequency of cell fusion events and the instability of fused cells have hindered our ability to understand the molecular mechanisms that govern cell fusion. We have developed a patterned gel system that can isolate cell fusion events and we demonstrate that several breast cancer cell lines can fuse into multinucleated giant cells in vitro, and the initiation and longevity of fused cells can be regulated solely by biophysical factors. Dynamically tuning the adhesive …
Kinetic Asymmetries During Submaximal And Maximal Speed Running, Devon H. Frayne
Kinetic Asymmetries During Submaximal And Maximal Speed Running, Devon H. Frayne
Masters Theses
An important issue for sports scientists, coaches and athletes is an understanding of the factors within a running stride that can enhance or limit maximal running speed. Previous research has identified many sprint-related parameters as potential kinetic limiters of maximal Center of Mass velocity (Chapman and Caldwell, 1983b; Weyand et al., 2001). Bilateral asymmetry is present for many of these parameters during running; however the degree to which such asymmetries change as running speed increases is unknown. It was hypothesized that asymmetries in key sprinting parameters would be larger at maximal speed than all other tested speeds. Kinematics and kinetics …