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A Detailed Mathematical Model Predicts Serial Engagement Of Ige-Fcεri Complexes Can Enhance Syk Activation In Mast Cells, Michael L. Blinov
A Detailed Mathematical Model Predicts Serial Engagement Of Ige-Fcεri Complexes Can Enhance Syk Activation In Mast Cells, Michael L. Blinov
UCHC Articles - Research
The term serial engagement was introduced to describe the ability of a single peptide, bound to a MHC molecule, to sequentially interact with TCRs within the contact region between a T cell and an APC. In addition to ligands on surfaces, soluble multivalent ligands can serially engage cell surface receptors with sites on the ligand, binding and dissociating from receptors many times before all ligand sites become free and the ligand leaves the surface. To evaluate the role of serial engagement in Syk activation, we use a detailed mathematical model of the initial signaling cascade that is triggered when FcepsilonRI …