Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Entire DC Network
Alterations Of The Gut Mycobiome In Patients With Ms - A Bioinformatic Approach, Saumya Shah
Alterations Of The Gut Mycobiome In Patients With Ms - A Bioinformatic Approach, Saumya Shah
Honors Scholar Theses
The mycobiome is the fungal component of the gut microbiome and is implicated in several autoimmune diseases. However, its role in multiple sclerosis (MS) has not been studied. We performed descriptive and formal statistical tests using the R language to characterize the gut mycobiome in people with MS (pwMS) and healthy controls. We found that the microbiome composition of multiple sclerosis patients is different from healthy people. The mycobiome had significantly higher alpha diversity and inter-subject variation in pwMS than controls. Additionally, Saccharomyces and Aspergillus were over-represented in pwMS. Different mycobiome profiles, defined as mycotypes, were associated with different bacterial …
Evaluating The Effect Of Glyphosate On Host Survival And Microbiome, Sandro Cloiseau
Evaluating The Effect Of Glyphosate On Host Survival And Microbiome, Sandro Cloiseau
Honors Scholar Theses
Glyphosate (N-(Phosphonomethyl) glycine) is the active ingredient in Round-Up Inc. Commonly known as a weed killer, glyphosate targets the enzyme 5-enolpyruvylshikimate-3- phosphate synthase (EPSPS) in the shikimate pathway. Ultimately, glyphosate selectively induces toxicity, targeting EPSPS present in plants and selected microorganisms. Therefore, glyphosate is anticipated to be harmless to animals and humans. Our laboratory studies Drosophila melanogaster - also known as the fruit fly, in an interest to understand its gut microbiota and immune system. The comparable immune response of the model organism is similar to honey bees, fungi, and humans. To understand the effect of glyphosate on host physiology, …
Identification And Analysis Of Feather Degrading Bacteria: A Search For Keratinase Genes, Nehal Navali
Identification And Analysis Of Feather Degrading Bacteria: A Search For Keratinase Genes, Nehal Navali
Honors Scholar Theses
Over two million tons of feather waste is generated annually by the poultry industry, the majority of which goes into landfills due to the difficulty of degrading its major component keratin. Although a portion of feather waste is eliminated via incineration or chemical treatment, the use of Feather Degrading Bacteria (FDB) has been proposed as a cheap and eco-friendly alternative. FDBs have been consistently isolated from the feather microbiome of birds and contain genes coding for the specialized protein keratinase which is able to degrade feathers. By doing so, feather waste, which is rich in nutrients, can be repurposed as …
Manipulation Of The Microbiome And Its Impact On Functional Recovery Following Ischemic Stroke, Michal Jandzinski
Manipulation Of The Microbiome And Its Impact On Functional Recovery Following Ischemic Stroke, Michal Jandzinski
Honors Scholar Theses
Each year, nearly 800,000 individuals residing in the United States will have a stroke. Of these, about 130,000 cases will prove fatal while many of the survivors will be forced to live with disability for the remainder of their lives. Out of all strokes over 87% are ischemic strokes. The widespread incidence of this debilitating condition costs the United States an estimated $36.5 billion dollars every single year. Despite this, clinicians are armed with very little to combat the disease. Recent research developments have brought about the rise in awareness about the importance of the microbiome, the various gut flora …