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Articles 1 - 13 of 13
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Evolution Of The Bacteriorhodopsin Gene Bop In Haloarchaea, Maulik Jitesh Jani
Evolution Of The Bacteriorhodopsin Gene Bop In Haloarchaea, Maulik Jitesh Jani
Honors Scholar Theses
Rhodopsins are among the most studied protein families. They all incorporate a light based chromophore and an opsin. They are found in all three domains of life and can be found in diverse environments, such as the membrane of the haloarchaea, Haloarcula (Haa) marismortui, growing on salt flats in Death Valley, to within human tissues and deep sea water (Briggs and Spudich 2005). Rhodopsins can serve multifarious purposes, from phototaxis away from harmful light to efficient energy generation. Bacteriorhodopsin is the best studied rhodopsin in haloarchaea. The evolutionary pattern of bacteriorhodopsin through its gene, bop, is the main focus of …
Elucidating The Mechanism Of Antimigratory Activity Of Cardiac Glycosides, Joshua H. Johnson
Elucidating The Mechanism Of Antimigratory Activity Of Cardiac Glycosides, Joshua H. Johnson
Honors Scholar Theses
The focus of this research is on cell migration and how it can be better understood through the use of small molecules that modulate cell migratory activity. The results have particular relevance in the realm of cancer pharmacology. Cardiac glycosides, which are known inhibitors of the eukaryotic Na+/K+-ATPase, have been determined to have antimigratory activities through the screening of several small molecule libraries. Here we investigate the antimigratory activities of the cardiac glycoside digitoxin as well as its analogs that we synthesized. Antimigratory activity was determined by conducting a wound closure assay with MDA-MB-231 human breast …
Effectiveness Of Marine Protected Areas Across A Latitudinal Gradient, Chelsea Roy
Effectiveness Of Marine Protected Areas Across A Latitudinal Gradient, Chelsea Roy
Honors Scholar Theses
Use of marine protected areas (MPA) as a tool for conservation and sustainable use of marine biological diversity is increasing worldwide. However, the geographic extent of MPA designation varies, as does a full understanding of the ecological utility of such designations. Progress towards marine conservation goals needs to be evaluated in order to determine areas lacking effective MPA designation. The goal of this study is to evaluate the representation (in terms of communities and habitats) and performance of marine protected areas in the Northwestern Atlantic and Northeastern Pacific across a latitudinal gradient. Presence or absence of MPAs in specific ecological …
Effect Of Plant-Derived Molecules On Acinetobacter Baumannii Biofilm On Abiotic Surfaces, Ryan P. Pelletier
Effect Of Plant-Derived Molecules On Acinetobacter Baumannii Biofilm On Abiotic Surfaces, Ryan P. Pelletier
Honors Scholar Theses
The emergence of multiple drug resistant (MDR) Acinetobacter baumannii has lead to an increased interest in finding alternative antimicrobial compounds for controlling the pathogen. The present study investigated the effect of three plant-derived antimicrobials, namely eugenol (EUG), carvacrol (CAR), and thymol (THY), on A. baumannii biofilms. Using concentrations equal to or greater than the minimum bactericidal concentration (MBC) of each compound, the ability of EUG, CAR, and THY to inactivate the mature biofilms of three strains of MDR A. baumannii on polystyrene microtiter plates and stainless steel coupons was examined. All three plant-derived compounds significantly inactivated the bioflims of all …
Salinity Preference Of Alaskan Threespine Stickleback: Test For Divergence In Halotaxis Between Ancestral And Landlocked Populations, David C. Fryxell
Salinity Preference Of Alaskan Threespine Stickleback: Test For Divergence In Halotaxis Between Ancestral And Landlocked Populations, David C. Fryxell
Honors Scholar Theses
Glacial retreat during the Pleistocene caused landlocking of anadromous Alaskan threespine stickleback, Gasterosteus aculeatus, furnishing a natural 'experiment' in osmoregulatory divergence. The objective of this study was to assess the effects of individual acclimation and population divergence on salinity preference. Full-sibling families of marine, anadromous, and freshwater-landlocked populations of stickleback were reared in common environments until 3 weeks post-hatch, then were split and acclimated to low or high salinity. At 6 to 8 weeks of age the six experimental groups were tested for salinity preference in a tank that offers fish a choice of compartments with different salinities arranged in …
Examination Of The Chromatin Structure Of Xlr3b Using The Chromosome Conformation Capture Assay, Sarah Elise Conderino
Examination Of The Chromatin Structure Of Xlr3b Using The Chromosome Conformation Capture Assay, Sarah Elise Conderino
Honors Scholar Theses
Imprinted genes contain epigenetic modifications that influence expression patterns based on parent-of-origin. Recent studies have shown that imprinted genes contribute to numerous human diseases and disorders. Xlr3b, an imprinted gene on the X chromosome, has been implicated in social and behavioral deficits characteristic of disorders such as Turner syndrome and autism. The imprinting mechanism of this gene is still unknown, and this study analyzed the native chromatin structure of Xlr3b through the chromosome conformation capture assay to determine if there are any long-range interactions that regulate the expression of this gene. Brain tissue from a mouse model of Turner …
Identifying Progenitor Cells Of Heterotopic Ossification, Eileen E. Semancik
Identifying Progenitor Cells Of Heterotopic Ossification, Eileen E. Semancik
Honors Scholar Theses
Heterotopic Ossification (HO) is the abnormal formation of bone within extraskeletal soft tissues. The condition can occur through both genetic and acquired means. Acquired cases of HO result from invasive surgery or traumatic injuries, with increasing prevalence of ectopic skeletogenesis as a result of combat-related blast injuries. HO has been characterized to some extent, including the histological features and the mutation underlying the genetic form, but the cells resident in skeletal muscle that represent the progenitors of heterotopic bone have yet to be determined. Only a few publications have attempted to definitively determine the progenitor cells in this disorder. Findings …
Improvements To The Forensic Analysis Of Mitochondrial Dna Typing, Elizabeth Montano
Improvements To The Forensic Analysis Of Mitochondrial Dna Typing, Elizabeth Montano
Honors Scholar Theses
Sequence analysis of human mitochondrial DNA (mtDNA) is an effective and reliable tool for the genetic characterization of forensic samples. The nature of the mitochondrial genome (mtgenome), its high copy number and small size (~17kb) makes it more resistant to degradation and more stable than nuclear DNA. For this reason mitochondrial DNA is often the only feasible option for the forensic analysis of environmentally compromised samples. Currently the forensic analysis of the mtgenome is restricted to the hypervariable regions, also known as the Displacement loop (d-loop). Previous studies, confirmed in the Strausbaugh lab, have demonstrated an increased variability in the …
Predictors Of 3pq And Quickboard Performance In Power-Oriented Collegiate Athletes, Brendan Putney
Predictors Of 3pq And Quickboard Performance In Power-Oriented Collegiate Athletes, Brendan Putney
Honors Scholar Theses
The measuring of athletic performance via pre participation experiments has been the norm for a long time from high school sports, all the way to professional athletics. These tests help gauge an athlete's physical growth over the offseason, as well as aid in predicting their potential performance in the future. However, performance may diminish as multiple maximum effort assessments are completed due to fatigue. The purpose of this study was to examine targeted assessments for possible novel qualities as performance predictors. Baseline data was taken from a larger performance enhancement study for analysis. Twenty-six men (age: 25+4 yr; height 1.78+0.07m; …
Metallothionein Gene Dose And The Immune Response, Meaghan Roy-O-Reilly
Metallothionein Gene Dose And The Immune Response, Meaghan Roy-O-Reilly
Honors Scholar Theses
Metallothionein (MT) is a small, cysteine-rich protein with significant immunomodulatory activity. It has been shown to play a critical role in important cellular mechanisms including heavy metal detoxification, essential metal management and the inflammatory response. MT production can be induced by a number of cellular stressors and acts to lessen the harmful effects of oxidizing agents and heavy metal exposure. Previous studies have shown that the dose of the metallothionein gene present in an individual may have significant effects on the adaptive immune response, yet the mechanism behind this phenomenon remains unknown. We hypothesize that the gene dose of metallothionein …
Evidence For Pit-Type (Slc20) And Napi-Ii-Type (Slc34) Transporters In The Rat Choroid Plexus, Hien M. Le
Evidence For Pit-Type (Slc20) And Napi-Ii-Type (Slc34) Transporters In The Rat Choroid Plexus, Hien M. Le
Honors Scholar Theses
: A major function of the brain choroid plexus (CP) is to regulate the exchange of solutes between the blood plasma and the cerebrospinal fluid (CSF) using selective transporters. CSF inorganic phosphate (Pi) concentration is maintained at about one-half that of plasma and is potentially important because of its regulatory, structural, and biochemical functions. Phosphate is critical for ATP and DNA formation, the linked regulation between phosphate and calcium, and as an intracellular buffer. The human body has two major Pi transporter gene families known as SLC34 (NaPi-II) and SLC20 (PiT), which have wide tissue distribution. Although …
The Role Of Actin Binding Proteins In Cell Motility, Elizabeth Ojukwu
The Role Of Actin Binding Proteins In Cell Motility, Elizabeth Ojukwu
Honors Scholar Theses
Actin binding proteins (ABPs) play key roles in the dynamic organization of the actin cytoskeleton during cell movement. The general localization of ABPs during dynamic cellular processes has been characterized. However, their specific functions and mechanisms of regulating the cytoskeleton during motile cellular processes remain unclear. Two approaches have been utilized to ask how these proteins contribute to cytoskeletal function during motility. Using homologous recombination, mutant cell lines lacking α-actinin, fimbrin or both proteins have been created. By analyzing mutants that lack these proteins, we hope to disrupt processes that require a functional cytoskeleton such as phagocytosis, random motility, development, …
The Effects Of Rectal Temperature And Hydration Status On Perceptual Ratings In Dehydrating Males, Ethan A. Talbot
The Effects Of Rectal Temperature And Hydration Status On Perceptual Ratings In Dehydrating Males, Ethan A. Talbot
Honors Scholar Theses
Athletes push the limits of what the human body can handle every day. When they exercise in the heat, they can attain dangerous levels of internal temperature and dehydration. Since athletes are sometimes not aware when they are experiencing severe hyperthermia or hypohydration, it is of interest to anyone who exercises in the heat to study whether athletes are consciously aware that they are approaching dangerous physiological limits. This study compares the perceptual values of athletes exercising in the heat to the changes in their internal temperature and hydration status, to see if athletes can reliably predict their heat and …