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Investigating The Effect Of Ethanol On Wnt7a And Its Potential Implications In Fetal Alcohol Spectrum Disorder, Erika Lytle
Investigating The Effect Of Ethanol On Wnt7a And Its Potential Implications In Fetal Alcohol Spectrum Disorder, Erika Lytle
Honors Undergraduate Theses
Fetal Alcohol Spectrum Disorders (FASDs), are caused by maternal alcohol consumption during pregnancy [3]. FASD encompasses a wide variety of cardiac and neural anomalies, while also associated with improper limb development, abnormal craniofacial features, problems within the central nervous system (CNS), and disabilities in learning and communication. Gene-regulating FASDs have not been well studied during the crucial phases of early embryonic development. Genes within the Wnt/Beta-catenin pathway control a vast amount of embryonic developmental processes. Among them is the Wnt7a gene, a significant downstream gene regulator which positively controls neural stem cell proliferation and cardiomyocyte differentiation on a large scale …