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The Effect Of A Senolytic Drug On Messenger Rna And Micro Rna Expression In Perigonadal Adipose Tissue Of Young And Old Mice, Catalina Hernandez
The Effect Of A Senolytic Drug On Messenger Rna And Micro Rna Expression In Perigonadal Adipose Tissue Of Young And Old Mice, Catalina Hernandez
Honors Undergraduate Theses
As we face an expanding elderly population and increased age-related chronic diseases, we must seek solutions that address interconnected problems. Dasatinib plus quercetin (D+Q), a novel combination drug, is a proposed solution to improve the health and longevity of aged individuals with minimal side effects, exceptional efficacy, and maximum convenience. In this experiment, intermittent D+Q treatment was completed on young and old mice. RNA was extracted from perigonadal adipose tissue and cDNA libraries of mRNA and miRNA were made. Real-time quantitative polymerase chain reaction was used to assess relative gene expression for mRNA and miRNA pertaining to cell senescence, inflammation, …