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Role Of Vascular Endothelial Growth Factor Receptor 2 Pathway Due To Preeclampsia: A Review, Firdous Ali
Role Of Vascular Endothelial Growth Factor Receptor 2 Pathway Due To Preeclampsia: A Review, Firdous Ali
Williams Honors College, Honors Research Projects
Preeclampsia is a pregnancy complication that is characterized mainly by hypertension in the mother. The exact pathogenesis of preeclampsia is unknown, although the disease is attributed to a number of factors such as angiogenic factor levels and endothelial dysfunction. Presently, the control program for the disease involves the delivery of the fetus and the placenta. There is a need to develop novel therapies that would control preeclampsia from the moment it is diagnosed to minimize the effects on the mother and child. VEGF is a protein involved in the pathogenesis of the condition. The defect in one of its receptors, …
Oxidative Stress Analysis Of Placental Tissue In The Rupp Pregnant Rat, Natalie Ganios
Oxidative Stress Analysis Of Placental Tissue In The Rupp Pregnant Rat, Natalie Ganios
Williams Honors College, Honors Research Projects
Preeclampsia is a disease associated with a vasoconstrictive phenotype due to disrupted signaling in the vascular endothelial growth factor (VEGF) relaxation pathway. The purpose of these studies is to determine the level of oxidative damage that is occurring in the placenta of the reduced uterine perfusion pressure (RUPP) rat, which serves as a common model for preeclampsia. RUPP and SHAM placenta tissue will be examined for oxidative stress as an indicator of tissue damage associated with the pathologically induced ischemia. Oxidative stress in the placental tissue will be measured by performing the following oxidative stress assays: 8-isoprostane test, TBARS assay, …
Effect Of Altered Vegfr2 Expression On Oxidative Stress In A Rodent Model Of Preeclampsia Pathology, Madison Kaser
Effect Of Altered Vegfr2 Expression On Oxidative Stress In A Rodent Model Of Preeclampsia Pathology, Madison Kaser
Williams Honors College, Honors Research Projects
Preeclampsia is a disease that results in pathologies in both the mother and the fetus that lead to oxidative stress. A decrease in vascular endothelial growth factor (VEGF) signaling may be one factor that contributes to this pathology. We hypothesize that by increasing vascular endothelial growth factor receptor 2 (VEGFR2) expression via administration of L-tyrosine phosphate (LTP) nanoparticles, the conditions of both the mother and fetus will be improved. Following treatment with the nanoparticles, we will employ a lucigenin chemiluminescence assay to determine levels of oxidative stress within the placenta. There are three groups that will be compared which are …