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Cadherin2 (N-Cadherin) Plays An Essential Role In Zebrafish Cardiovascular Development, Brian Bagatto, Jessie Francl, Bei Liu, Qin Liu
Cadherin2 (N-Cadherin) Plays An Essential Role In Zebrafish Cardiovascular Development, Brian Bagatto, Jessie Francl, Bei Liu, Qin Liu
Biology Faculty Research
Background: Cadherins are cell surface adhesion molecules that play important roles in development of vertebrate tissues and organs. We studied cadherin2 expression in developing zebrafish heart using in situ hybridization and immunocytochemical methods, and we found that cadherin2 was strongly expressed by the myocardium of the embryonic zebrafish. To gain insight into cadherin2 role in the formation and function of the heart, we analyzed cardiac differentiation and performance in a cadherin2 mutant, glass onion (glo).
A Three-Dimensional Functional Assessment Of Heart And Vessel Development In The Larva Of The Zebrafish (Danio Rerio), Brian Bagatto, Warren Burggren
A Three-Dimensional Functional Assessment Of Heart And Vessel Development In The Larva Of The Zebrafish (Danio Rerio), Brian Bagatto, Warren Burggren
Biology Faculty Research
There has been considerable recent interest in the development of the circulation in the zebrafish. Optical techniques typically used to visualize changes in heart size allow measurement of stroke volume during early vertebrate development, but this approach is complicated in zebrafish larvae because of the heart's irregular shape and its significant change in morphology during the first 6 d of development. By use of a three-dimensional integration of the early zebrafish heart and vessels, we have greatly reduced measurement error of stroke volume and cardiac output and have determined the cross-sectional growth of major vessels in the developing zebrafish larvae. …