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Androgen Receptor And The Testes Influence Hypertension In A Hybrid Rat Model, Daniel Ely, Ron Salisbury, Disha Hadi, Monte E. Turner, Mark L. Johnson
Androgen Receptor And The Testes Influence Hypertension In A Hybrid Rat Model, Daniel Ely, Ron Salisbury, Disha Hadi, Monte E. Turner, Mark L. Johnson
Biology Faculty Research
The objective of this study was to determine if males with a deficient androgen receptor would develop hypertension when crossed with a hypertensive parent. Female King-Holtzman rats (n = 15), heterozygous for the testicular feminization (Tfm) gene, were crossed with male spontaneously hypertensive rats (SHR), and blood pressure was measured weekly from 5-14 weeks in the F1 hybrid males. Approximately 50% of the F1 hybrid males were Tfm males and androgen receptor-deficient, and 50% were normal. Blood pressure in the parent King-Holtzman males, Tfms, and female rats was also followed for the same time period. The F1 normal male hybrids …
Separate Sex-Influenced And Genetic Components In Spontaneously Hypertensive Rat Hypertension, Monte E. Turner, Mark L. Johnson, Daniel Ely
Separate Sex-Influenced And Genetic Components In Spontaneously Hypertensive Rat Hypertension, Monte E. Turner, Mark L. Johnson, Daniel Ely
Biology Faculty Research
Previous results from our laboratory indicated two major genetic components of spontaneously hypertensive rat (SHR) hypertension, an autosomal component and a Y chromosome component. Two new substrains, SHR/a and SHR/y, were developed using a series of backcrosses to isolate each of these components. The SHR/a substrain has the autosomal loci and X chromosome from the SHR strain and the Y chromosome from the Wistar-Kyoto (WKY) rat strain. The SHR/y substrain has only the Y chromosome from the SHR and autosomal loci and X chromosome from the WKY strain. Throughout these breeding programs parents were chosen at random without selection for …