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Biphasic Targeting And Cleavage Furrow Ingression Directed By The Tail Of A Myosin Ii, X. Fang, J. Y. Luo, R. Nishihama, C. Wloka, C. Dravis, M. Travaglia, M. Iwase, Elizabeth Ann Vallen, E. Bi
Biphasic Targeting And Cleavage Furrow Ingression Directed By The Tail Of A Myosin Ii, X. Fang, J. Y. Luo, R. Nishihama, C. Wloka, C. Dravis, M. Travaglia, M. Iwase, Elizabeth Ann Vallen, E. Bi
Biology Faculty Works
Cytokinesis in animal and fungal cells utilizes a contractile actomyosin ring (AMR). However, how myosin II is targeted to the division site and promotes AMR assembly, and how the AMR coordinates with membrane trafficking during cytokinesis, remains poorly understood. Here we show that Myo1 is a two-headed myosin II in Saccharomyces cerevisiae, and that Myo1 localizes to the division site via two distinct targeting signals in its tail that act sequentially during the cell cycle. Before cytokinesis, Myo1 localization depends on the septin-binding protein Bni5. During cytokinesis, Myo1 localization depends on the IQGAP Iqg1. We also show that the Myo1 …
Bioluminescent Escherichia Coli Strains For The Quantitative Detection Of Phosphate And Ammonia In Coastal And Suburban Watersheds, Cristina V. Cardemil , '01, D. R. Smulski, R. A. Larossa, Amy Cheng Vollmer
Bioluminescent Escherichia Coli Strains For The Quantitative Detection Of Phosphate And Ammonia In Coastal And Suburban Watersheds, Cristina V. Cardemil , '01, D. R. Smulski, R. A. Larossa, Amy Cheng Vollmer
Biology Faculty Works
Accumulation of phosphate and ammonia in estuarine systems and subsequent dinoflagellate and algal blooms has been implicated in fish kills and in health risks for fishermen. Analytic chemistry kits are used to measure phosphate and ammonia levels in water samples, but their sensitivity is limited due to specificity for inorganic forms of these moieties. An Escherichia coli bioluminescent reporter system measured the bioavailability of inorganic nutrients through fusion of E. coli promoters (phoA or glnAp2) to the luxCDABE operon of Vibrio fischeri carried either on the chromosome or on a multicopy plasmid vector, resulting in emission of light in response …
Pharmacological And Genetic Reversal Of Age-Dependent Cognitive Deficits Attributable To Decreased Presenilin Function, S. M.J. Mcbride, C. H. Choi, B. P. Schoenfeld, A. J. Bell, D. A. Liebelt, D. Ferreiro, R. J. Choi, P. Hinchey, M. Kollaros, A. M. Terlizzi, N. J. Ferrick, E. Koenigsberg, R. L. Rudominer, A. Sumida, S. Chiorean, Kathleen King Siwicki, H. T. Nguyen, M. E. Fortini, T. V. Mcdonald, T. A. Jongens
Pharmacological And Genetic Reversal Of Age-Dependent Cognitive Deficits Attributable To Decreased Presenilin Function, S. M.J. Mcbride, C. H. Choi, B. P. Schoenfeld, A. J. Bell, D. A. Liebelt, D. Ferreiro, R. J. Choi, P. Hinchey, M. Kollaros, A. M. Terlizzi, N. J. Ferrick, E. Koenigsberg, R. L. Rudominer, A. Sumida, S. Chiorean, Kathleen King Siwicki, H. T. Nguyen, M. E. Fortini, T. V. Mcdonald, T. A. Jongens
Biology Faculty Works
Alzheimer's disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a single copy of the Presenilin (PS) and amyloid precursor protein genes. The dominant inheritance pattern of FAD indicates that it may be attributable to gain or change of function mutations. Studies of FAD-linked forms of presenilin (psn) in model organisms, however, indicate that they are loss of function, leading to the possibility that a reduction in PS activity might contribute to FAD …