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Hard-Sphere-Like Dynamics In Highly Concentrated Alpha-Crystallin Suspensions, Preeti Vodnala, Laurence Lurio, Michael C. Vega, Elizabeth Gaillard

Faculty Peer-Reviewed Publications

The dynamics of concentrated suspensions of the eye-lens protein alpha crystallin have been measured using x-ray photon correlation spectroscopy. Measurements were made at wave vectors corresponding to the first peak in the hard-sphere structure factor and volume fractions close to the critical volume fraction for the glass transition. Langevin dynamics simulations were also performed in parallel to the experiments. The intermediate scattering function f(q,τ) could be fit using a stretched exponential decay for both experiments and numerical simulations. The measured relaxation times show good agreement with simulations for polydisperse hard-sphere colloids.

Risk Factors For The Female Athlete Triad In College Age Athletes Compared To Non-Athletes, Micaela Shirley Miller

Graduate Research Theses & Dissertations

The Female Athlete Triad (Triad) is the three interrelated conditions of low energy availability with or without disordered eating, menstrual irregularity or amenorrhea, and osteoporosis, and is a health concern that affects active women of all ages who participate in physical activity. Although associations have been found between the individual components of the Triad, research is still limited on all Triad components occurring simultaneously in athletes. In addition, research on the college-age female population is currently limited. The purpose of this study was to examine Triad risk factors in the college-age female athlete population compared to the non-athlete population, specifically …

Modulation Of Autophagy In Gbm Cells By Clinical Doses Of Gamma Radiation, Devron Ozgen

Graduate Research Theses & Dissertations

Glioblastoma (GBM) is a highly aggressive cancer that forms from the astrocytes of the brain. Poor prognosis and rather unsuccessful treatment regimens have left researchers and patients looking for new therapeutic strategies to combat this dreadful disease. Following tumor resection and radiotherapy combined with temozolomide, survival only remains around 15 months. Recurrence is very commonly seen, and urgently needs to be further understood. Autophagy is an important mechanism within cancer cells, which allows for cellular organelle/amino acid recycling and thus contributes to energy metabolism. Autophagy machinery has been shown to control cell death within cancer cells, leading to our interest …

The Rtfa Gene Regulates Plant And Animal Pathogenesis And Secondary Metabolism In Aspergillus Flavus, Jessica Michelle Lohmar

Graduate Research Theses & Dissertations

Aspergillus flavus is an opportunistic fungal plant and human pathogen and producer of mycotoxins including aflatoxin B1 (AFB1). As part of our ongoing studies to elucidate biological functions of the A. flavus rtfA gene, we examined its role in pathogenicity of both plant and animal model systems. rtfA encodes a putative RNA-Pol II transcription elongation factor, previously characterized in Saccharomycese cerevisiae, Aspergillus nidulans, Aspergillus fumigatus, where it was shown to regulate several important cellular processes, including morphogenesis, secondary metabolism. In addition, an initial study in A. flavus indicated that rtfA also influences development and production of AFB1, however its effect …

Food Insecurity, Depression, Disordered Eating Styles, And Body Mass Index Among University Students, Cristal Medina

Graduate Research Theses & Dissertations

Food insecurity is higher among college students than in the general population. Food insecurity can lead to a variety of health outcomes. The present cross-sectional study investigated the relationship between food insecurity and body mass index (BMI), depression, and disordered eating among university students. The study was carried out at eight public universities in the Midwest.

Students at participating universities in the Midwest were recruited electronically. They were asked to complete an online survey which consisted of the U.S. Adult Food Security Scale, the Center for Epidemiological Studies Depression Scale, and the Three Factor Eating Questionnaire. Participants were also asked …

Factors Affecting Disordered Eating Among College Freshmen Upon Entering College, Libby Micaela Moser

Graduate Research Theses & Dissertations

Purpose: There is a gap in literature on disordered eating among college freshmen since 2011. Research has shown that disordered eating manifests itself during adolescence and is likely to transcend into adulthood1,7,8,9,14,15. The freshmen year in college is likely to be challenging for many students. During this time, they may develop disordered eating or perpetuate an existing condition3,4,14,15. This research study investigated the prevalence of disordered eating among college freshmen and factors that may impact this development. A comparison of prior history of disordered eating was also examined.

Methods: A cross-sectional survey study was conducted on college freshmen at Northern …

Effect Of Tart Cherry Concentrate On Pain, Inflammation, And Strength, Natasha Kirkbride

Graduate Research Theses & Dissertations

The purpose of this double-blinded, randomized control study was to assess the impact of tart cherry concentrate on pain, inflammation, and strength in resistance-trained males (n = 24). Specifically, it analyzed the impact of tart cherry supplementation following an eccentric exercise protocol without the use of NSAIDs. Participants received their supplementation of either tart cherry concentrate (TC) or the placebo (PL) to consume over 8 consecutive days. Participants supplemented twice daily with either the TC concentrate (one ounce of concentrate mixed with water) or the placebo. On day 5 of the study, participants completed an eccentric knee extension exercise with …

Effects Of Management On Functional Diversity In Restored Tallgrass Prairie Plant Communities, Anna K. Farrell

Graduate Research Theses & Dissertations

While recent studies have embraced evaluating ecosystems through functional diversity, the focus on interspecific trait changes may limit their usefulness and application. Functional traits (traits that explain species’ responses to environmental conditions and their ecosystem roles) can provide a more nuanced understanding of how disturbances shape plant communities and the functions they perform. Further, the inclusion of intraspecific trait responses can explain a significant portion of these relationships. In ecosystem restorations, management strategies can act as environmental drivers and disturbances that affect community structure. This study examined how three environmental drivers (grazer presence, prescribed fire, and age) in restored grasslands …

Orthorexia Nervosa In Undergraduate Health Majors: Using Yoga As An Intervention, Ashley Kyle

Graduate Research Theses & Dissertations

Purpose and Objectives: While much is known about common eating disorders in undergraduate students in college, limited research is available on the prevalence of orthorexia nervosa (ON). Orthorexia nervosa is a fixation on righteous eating that typically stems from an attempt to diet or consume healthier foods and turns into an obsession with the quality and purity of food. This type of behavior can become extremely restrictive, damage mental and physical health, and may lead disruptions in daily life. Specifically, information is lacking on the prevalence of ON in health majors, how to classify this disorder, and how to treat …

Evaluation Of Ispe For Inhibitor Design In The Non-Mevalonate Pathway, Kataryzna B. Hoerchler

Graduate Research Theses & Dissertations

There is an urgent need to discover new antibiotics to combat the emergence of drug resistant Novel antibiotics that target unique pathways different from existing therapies are promising targets. The non-mevalonate pathway (MEP), which was discovered in the 1990’s, is essential for most bacteria, plants and apicomplexan parasites. Inhibition of the non-mevalonate is an attractive pharmaceutical target, since it is not present in mammals. Many compounds have surfaced as potential inhibitors, but none have made it to market. This thesis investigates the fourth step in the MEP pathway involving the enzyme 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Escherichia coli (Ec), Burkholderia thailandensis …

Quantitation Without Calibration: Response Profile As An Indicator Of Target Amount, Mrittika Debnath

Graduate Research Theses & Dissertations

Quantitative assessment of biomarkers is essential in numerous contexts from decision-making in clinical situations to food quality monitoring to the interpretation of life-science research findings. However, appropriate quantitation techniques are not as widely addressed as detection methods. One of the major challenges in biomarker’s quantitation is the need to have a calibration for correlating a measured signal to a target amount. The step complicates the methodologies and makes them less sustainable. In this work, we addressed the issue via a new strategy: relying on the position of response profile rather than absolute signal for assessment of a target nucleic acid’s …