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Effects Of Adrenergic Or A Combination Of Adrenergic And Opioid Drugs On Assessments Of Insulin Sensitivity In Mares, Lauren Kerrigan
Effects Of Adrenergic Or A Combination Of Adrenergic And Opioid Drugs On Assessments Of Insulin Sensitivity In Mares, Lauren Kerrigan
LSU Master's Theses
Excitement is a problem when conducting endocrine tests on fractious horses. Epinephrine (EPI), for example, was shown to obliterate the insulin-induced decrease in blood glucose concentrations. Sedation may be a solution; however, perturbation of results may preclude useful information. The objectives of the four experiments presented herein were 1) to determine the effects of EPI on insulin response to glucose infusion (IR2G), 2) to assess the effects of the α-adrenergic sedative, detomidine (DET), alone or in combination with the opioid agonist, butorphanol (BUT), on IR2G and glucose response to insulin (GR2I), and 3) to assess the effects of BUT alone …
Changes In Plasma Melanocyte Stimulating Hormone, Acth, Prolactin, Gh, Lh, Fsh, And Thyroid Stimulating Hormone In Response To Injection Of Sulpiride, Thyrotropin Releasing Hormone, Or Vehicle In Insulin Sensitive And Insensitive Mares, Nicole Arana Valencia
LSU Master's Theses
Six insulin sensitive and six insensitive mares were used in a replicated 3 x 3 Latin square design to determine the pituitary hormonal responses (compared to vehicle) to sulpiride and thyrotropin-releasing hormone (TRH), two compounds commonly used to diagnose pituitary pars intermedia dysfunction (PPID) in horses. Mares were classified as insulin sensitive or insensitive by their previous glucose responses to direct injection of human recombinant insulin. Treatment days were February 25 and March 10 and 24, 2012. Treatments were sulpiride (racemic mixture, 0.01 mg/kg BW), TRH (0.002 mg/kg BW), and vehicle (saline, 0.01 mL/kg BW) administered intravenously. Blood samples were …
Evaluation Of Methods For Suppressing Estrus And Ovulation In Mares: Sustained Release Injections Of Altrenogest Versus Deslorelin Acetate, Thomas J. Stevens
Evaluation Of Methods For Suppressing Estrus And Ovulation In Mares: Sustained Release Injections Of Altrenogest Versus Deslorelin Acetate, Thomas J. Stevens
LSU Master's Theses
Two experiments assessed the potential of altrenogest, an artificial progestogen, and deslorelin acetate, a gonadotropin-releasing hormone (GnRH) agonist, for suppressing estrus and ovulation in cyclic mares. In the first experiment, mares were administered a luteolytic dose of prostaglandin-F2á on d 6 of diestrus, and were then treated with 1 of 3 formulations of altrenogest in slow-release vehicle (6 mares/group): 1) Biorelease altrenogest LA150 (225 mg total as a 1.5 mL injection); 2) Biorelease altrenogest LA225 (225 mg total as a 1.0 mL injection); or 3) Biorelease altrenogest LA225 (450 mg total as a 2.0 mL injection). Six control mares received …
Reproductive And Metabolic Effects Of Recombinant Equine Leptin On Seasonally Anovulatory Mares, Pamela Boliew Mitcham
Reproductive And Metabolic Effects Of Recombinant Equine Leptin On Seasonally Anovulatory Mares, Pamela Boliew Mitcham
LSU Master's Theses
Mares of poor body condition have low plasma leptin concentrations, while obese mares have the highest concentrations. Leptin is a primary signal of body condition to the brain in other species; therefore, low leptin concentrations in thin mares could contribute to their extended anovulatory period in winter compared to obese mares. The current experiment was designed to determine whether recombinant equine leptin, administered to seasonally anovulatory mares, would induce ovarian activity and ovulation in the winter. Leptin effects on metabolism were also studied. Beginning January 7, leptin-treated mares (n = 9) received daily i.m. injections of 10 mg recombinant equine …
Reproductive Characteristics Of High Body Condition Mares With High Versus Low Leptin Concentrations, Cara A. Waller
Reproductive Characteristics Of High Body Condition Mares With High Versus Low Leptin Concentrations, Cara A. Waller
LSU Master's Theses
Two experiments were performed to discover what, if any, reproductive differences exist in high body condition (BCS) mares with varying concentrations of leptin. Previous research showed that mares with high body condition scores can have a range of leptin levels, from very low (<5 ng/mL) to very high (>10 ng/mL). Earlier results indicated that most mares with high body condition scores maintain estrous cycles or show significant follicular activity during the winter. Among these high BCS mares, about 30% of them exhibit hyperleptinemia and hyperinsulinemia. The first experiment was designed to compare the reproductive characteristics of high BCS mares with high versus low leptin …
Follicular Growth And Development And Gonadotropin Response Of Mares Treated With Dihydrotestosterone And Estradiol Benzoate, Scarlett Lynn Mcmeen
Follicular Growth And Development And Gonadotropin Response Of Mares Treated With Dihydrotestosterone And Estradiol Benzoate, Scarlett Lynn Mcmeen
LSU Master's Theses
An experiment was conducted to determine the effects of dihydrotestosterone (DHT) and estradiol benzoate (EB) given simultaneously on concentrations of FSH and LH and the associated follicular activity, and to monitor the subsequent recovery of the gonadotropes and follicular growth following treatment with either DHT or EB. Twelve mares were assigned to daily treatments of DHT (150 Fg/kg BW) plus EB (22 Fg/kg BW) from d 0 through 30 (Phase I). Beginning on d 31, mares were randomly assigned to one of three treatment groups: 1) oil, 2) DHT (150 Fg/kg BW), or 3) EB (22 Fg/kg BW). On d …