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Tonic And Phasic Inhibitory Mechanisms Mediating Sensorimotor Decision-Making In The Goldfish Auditory Startle Circuit, Paul C.P. Curtin
Tonic And Phasic Inhibitory Mechanisms Mediating Sensorimotor Decision-Making In The Goldfish Auditory Startle Circuit, Paul C.P. Curtin
Dissertations, Theses, and Capstone Projects
This work describes related studies of cellular and synaptic signaling mechanisms involved in the balance of excitation and inhibition in the goldfish auditory startle circuit. The general purpose of these experiments was to identify novel mechanisms that contribute to action selection at different stages of the motor control hierarchy. The methods applied to achieve this goal tested the effects of selective antagonists for target receptor systems on sound-evoked excitation and inhibition of startle.
Chapter 2 describes a study of a poorly-understood serotonergic mechanism, the 5-HT5A receptor, that was not previously functionally characterized in native tissues or associated with neural …