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Y-Chromosome Polymorphisms In Southern Arabia, Alicia M. Cadenas
Y-Chromosome Polymorphisms In Southern Arabia, Alicia M. Cadenas
FIU Electronic Theses and Dissertations
In order to explore south Arabia's role in the migratory episodes leaving Africa to Eurasia and back, high-resolution Y-chromosome analyses of males from the United Arab Emirates (164), Qatar (72) and Yemen (62) were performed. The distribution of specific haplogroups (E3bl-M35 and J1-M267) and their microsatellite-based age estimates in southern Arabia offer additional insight on their dissemination. With the exception of Yemen, southern Arabia displays high diversity in its Y-haplogroup substructure and share similarities with populations along the eastern coast of the Gulf of Oman, possibly serving as a coastal corridor for migrations. Elevated rates of consanguinity may have had …
Biochemical Characterization Of Mammalian High Mobility Group Protein A2, Lorraine Katy Edwards
Biochemical Characterization Of Mammalian High Mobility Group Protein A2, Lorraine Katy Edwards
FIU Electronic Theses and Dissertations
The high mobility group protein HMGA2 is an architectural transcription factor, which is expressed during embryogenesis. Aberrant expression causes benign and malignant tumor formation. The protein possesses three "AT hook" domains and an acidic Cterminal. HMGA2 is natively unstructured, however it forms a homodimer. In this study site-directed mutagenesis was used to create single methionine mutants, HMGA2Q37M, HMGA2I71M and HMGA2Q85M. These mutants were cross-linked using EDC and then cleaved using CNBr to determine which domains are involved in homodimer formation. Our results indicate that the second "AT hook" domain may interact with the C-terminal. We then labeled a peptide containing …
The Role Of Amplicon Length Heterogeneity-Polymerase Chain Reaction In Microbial Community Profiling And Presumptive Testing Of Bioagents, Melissa S. Doud
The Role Of Amplicon Length Heterogeneity-Polymerase Chain Reaction In Microbial Community Profiling And Presumptive Testing Of Bioagents, Melissa S. Doud
FIU Electronic Theses and Dissertations
Due to the threat of bioterrorist acts, there is a need to develop techniques that rapidly detect possible bioagents. Amplicon length heterogeneity-polymerase chain reaction (ALH-PCR) presumptively identifies eubacteria in samples by detecting differences between the lengths of the hypervariable regions of the 16S rRNA gene. To study the efficiency, reproducibility, and reliability of the technique, sputum from cystic fibrosis (CF) patients has been chosen as the model system. There is an abundance of microorganisms in the sputum of the CF lung. Using ALH-PCR, the complex microbial diversity and vast community composition in the lungs of the CF patients were studied. …
Improving Civil Jury Decision-Making : Evidentiary And Procedural Issues, Julian A. Gilbert
Improving Civil Jury Decision-Making : Evidentiary And Procedural Issues, Julian A. Gilbert
FIU Electronic Theses and Dissertations
The civil jury has been under attack in recent years for being unreliable and incompetent. Considering the myriad causes for poor civil juror decision-making, the current investigation explores both procedural and evidentiary issues that impact juror's decisions. Specifically, the first phase of this dissertation examines how jurors (mis)use evidence pertaining to the litigants when determining liability and awarding damages. After investigating how jurors utilize evidence, the focus shifts to exploring the utility of procedural reforms designed to improve decision-making (specifically revising the instructions on the laws in the case and bifurcating the damage phases of the trial). Using the results …