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Investigation Of Optimal Dosing Strategies For Ertapenem For Varying Bmi Using Mathematical Modeling, Bethany Jewett
Investigation Of Optimal Dosing Strategies For Ertapenem For Varying Bmi Using Mathematical Modeling, Bethany Jewett
Undergraduate Honors Theses
Previous research suggests that the efficacy of Ertapenem, a carbapenem antibiotic administered intravenously, is related to a patient’s body mass index. Using an existing physiologically based pharmacokinetic (PBPK) model for Ertapenem, we constructed a least squares inverse problem to determine an optimal dose for males with varying body weights and heights. The criteria for an optimal dose was based upon pharmacokinetic and pharmacodynamic (PK/PD) parameters calculated for a male with a body height of 175 cm and a weight of 72 kg. We also adjusted dosing intervals to ensure that effective concentration of drug between doses was the same for …