Digital Commons Network^™

The Effect Of Topical Cannabidiol On The Progression Rate Of Delayed Onset Muscle Soreness, Anastasia Alpy, George Yusuff, Michele Aquino, John Petrizzo, Robert M. Otto, John Wygand, Troy Simpson

International Journal of Exercise Science

International Journal of Exercise Science 16(3): 1426-1439, 2023. This study investigated the efficacy of topical cannabidiol (CBD) ointment in reducing localized inflammation, minimizing performance detriments, and attenuating soreness associated with delayed onset muscle soreness (DOMS). In a double blind randomized control trial, upper-arm circumferences, maximal voluntary isometric contractions (MVICs) for elbow flexion at 90° and 30° for college-aged participants (n = 21, age 20.8 ± 1.9 years) were assessed at baseline. Participants then performed a DOMS-inducing protocol for the biceps brachii. Topical CBD ointment and placebo (P) ointment were randomly assigned and applied 30 minutes, 24, 48 and 72 …

Effects Of High-Speed Training On Messenger Rna Expression In Two-Year-Old Thoroughbred Racehorses, Mackenzie Grace Johnson

Theses and Dissertations--Veterinary Science

Accumulating high-speed exercise has been identified as a significant risk factor for catastrophic injuries in racing Thoroughbreds. Injuries, regardless of severity, are a main cause of withdrawal from the racing industry, raising animal welfare concerns and resulting in significant economic losses. While most of the current literature focuses on catastrophic injuries incurred during racing rather than training, the present study aims to help fill this gap as well as discuss the associated risk factors. The evaluation of messenger RNA (mRNA) expression changes provides an efficient and straightforward approach to identifying horses at risk for catastrophic injury. While alternative injury risk …

Effects Of Varying Load Intensity On Skeletal Muscle Damage Between Two Isovolumic Resistance Exercise Bouts, Lee J. Winchester, Cody E. Morris, Patton Allen, Teresa Wiczynski, Scott W. Arnett, T. Scott Lyons

International Journal of Exercise Science

International Journal of Exercise Science 15(4): 1212-1221, 2022. There are limited data comparing the efficacy of resistance loads within the hypertrophy range for promoting muscular growth, particularly when similar training volumes are utilized. The purpose of this study was to determine if two similar volume-loads, utilizing different intensities, would produce dissimilar muscular damage and inflammation. Eleven resistance-trained, college-aged males participated in this study. After testing 1RM barbell squats, participants completed two similar volume-load barbell squat sessions at two different resistance loads (67% and 85% of 1RM) on two separate visits. Venous blood samples were collected at baseline and one hour …

Impact Of An Acute Bout Of Submaximal Aerobic Exercise On Circulating Leukocytes In Individuals With Spinal Cord Injury, Garett S. Jackson, Kendra R. Todd, Jan W. Van Der Scheer, Jeremy J. Walsh, Gabriel U. Dix, Kathleen A. Martin Ginis, Jonathan P. Little

International Journal of Exercise Science

International Journal of Exercise Science 15(3): 1085-1104, 2022. Individuals with spinal cord injury (SCI) may experience cardiovascular, musculoskeletal and organ function dysregulation. Sequelae include reduced catecholamine secretion and attenuated immune responses which may impact exercise-induced leukocytosis. The purpose of this study was to characterize major leukocyte subtypes following 30 minutes of acute, submaximal aerobic exercise, in line with updated international SCI exercise guidelines for adults. It was hypothesized that exercise would increase major leukocyte subtypes when compared to fasted baseline. Eight participants with SCI (incomplete n = 6; complete n = 2) completed a 30-minute bout of aerobic exercise on …

Montmorency Cherry Juice Consumption Does Not Improve Muscle Soreness Or Inhibit Pro-Inflammatory Monocyte Responses Following An Acute Bout Of Whole-Body Resistance Training., Devin Drummer, Kelly Pritchett, Gina M. Many, Blaise Dondji, Kathleen Connor, Jerusalem Tesfaye, Mark Young, Robert C. Pritchett

International Journal of Exercise Science

International Journal of Exercise Science 15(6): 686-701, 2022. Montmorency Cherry Juice (MCJ) may­­­ improve acute exercise recovery by attenuating inflammation and oxidative stress. However, the anti-inflammatory effects of MCJ on monocyte responses following resistance exercise have not been explored. Seven resistance-trained males (age: 22.9 ± 4.1 yrs; height: 1.8 ± 0.1 m; weight: 81.7 ± 13.2 kg) participated in this study. Participants completed a placebo-controlled crossover design, drinking either MCJ or placebo beverages, 7 days prior to completing an acute bout of unilateral resistance exercise. Statistical significance was assessed using a within-subjects repeated measures ANOVA; alpha level p ≤ 0.05. …

The Effects Of Water With Anti-Inflammatory Capabilities (Wac) On Circulating Inflammatory Biomarkers At Rest And Following Resistance Exercise, Brittany Martin

Health, Human Performance and Recreation Undergraduate Honors Theses

Purpose: To determine the effects of waters with anti-inflammatory capabilities (WAC) influence circulating inflammatory biomarkers at rest and following resistance exercise. Methods: Participants completed a heavy lifting protocol and drank water with anti-inflammatory capabilities for a total of six weeks. Blood samples were taken at different at 9 different time intervals to assess concentrations of anti-inflammatory markers and to quantify inflammatory biomarkers. Those time intervals included pre-AHREP 1 and post-AHREP 1, 24-hr post-AHREP 1, 48-hr post-AHREP 1, 3-week check-up, pre-AHREP 2, post-AHREP 2, 24-hr post-AHREP 2, and 48-hr post-AHREP 2. Background: The biomarkers that were focused on were: IL-6 …

The Effects Of Aerobic-Resistance Training And Broccoli Supplementation On Plasma Dectin-1 And Insulin Resistance In Males With Type 2 Diabetes, Ayoub Saeidi, Mohammad Soltani, Ali Daraei, Hanieh Nohbaradar, Marjan Mosalman Haghighi, Nikoo Khosravi, Kelly E. Johnson, Ismail Laher, Anthony C. Hackney, Trisha Vandusseldorp, Hassane Zouhal

Faculty Articles

BACKGROUND: This study aimed to evaluate the effects of a combination of aerobic-resistance training (CARET) and broccoli supplementation on dectin-1 levels and insulin resistance in men with type 2 diabetes mellitus (T2D). METHODS: Forty-four males with T2D were randomly allocated to four groups ( = 11 each group): CARET + broccoli supplement (TS), CARET + placebo (TP), control + broccoli supplement (S), and control + placebo (CP). CARET was performed three days per week for 12 weeks. TS and S groups received 10 g of broccoli supplement per day for 12 weeks. All variables were assessed at baseline and 12 …

Body Composition, Metabolism And Inflammation In Breast Cancer Survivors And Healthy Age-Matched Controls: A Cross-Sectional Analysis, Takudzwa A. Madzima, Caroline D. Deaterly

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 1108-1119, 2020. Breast cancer survivors (BCS) experience treatment induced alterations in body composition including the loss of bone mineral density (BMD) and lean soft tissue (LST). These changes can affect the metabolism and the systemic inflammatory environment of BCS. Objective: To evaluate the differences in body composition, resting energy expenditure (REE), and inflammation in BCS and age-matched women without a prior cancer diagnosis (control). Methods: Seventeen post-menopausal BCS (stages 0-III; age: 59 ± 9 years) and 18 (59 ± 6 years) controls had their total body and regional (lumbar spine, femur, and forearm) BMD, …

Effects Of Intermittent Pneumatic Compression On Delayed Onset Muscle Soreness (Doms) In Long Distance Runners, Shane Draper, Emily Kullman, Kenneth E. Sparks, Kathleen D. Little, Joan Thoman

International Journal of Exercise Science

International Journal of Exercise Science 13(2): 75-86, 2020. The purpose of this study was to observe the effectiveness of intermittent pneumatic compression (IPC) on reducing C-reactive protein (CRP) and DOMS after long distance running.Ten distance runners, five males and five females, ages 20-53 years performed two 20-mile runs at 70% VO₂max. Each run was followed by either no treatment (control) or IPC treatment for five consecutive days. For the IPC run, participants were treated for one hour immediately following the run and daily for five more days thereafter. On control runs, participants did not receive any treatment. …

Biomarkers Of Inflammation In Heart Failure Patients With Reduced And Preserved Ejection Fractions: Multi-Ethnic Study Of Atherosclerosis, Michelle Lynne Stone

UNF Graduate Theses and Dissertations

Purpose Examine the relationships between high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and soluble tumor necrosis factor-α receptor-1 (sTNF-R1) and the cumulative risk of heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fractions in a diverse, population-based sample. Methods Study sample included 6,814 adult (45-84 years of age) men and women who participated in the Multi-Ethnic Study of Atherosclerosis and were free of cardiovascular disease at baseline. Cox regression was used to calculate the hazard ratios (HR) associated with elevated baseline hs-CRP (> 3-10 mg/L), IL-6 (> 75^th percentile) and sTNF-R1 (> 75^th percentile) and risk of overall …

Toll-Like Receptor 4 Inhibition Differentially Impacts Intervertebral Disc Axial Mechanics In Wild Type And Sparc-Null Mice, Mitch Whittal

Theses and Dissertations (Comprehensive)

Study Design. In vivo examination of the influence of TAK-242 (resatorvid) treatment on the mechanical properties of the intervertebral disc (IVD) in secreted protein acidic and rich in cysteine (SPARC) gene knockout (SPARC-null) mice.

Objectives. To examine if chronic TAK-242 treatment mitigates mechanical degradation associated with IVD degeneration in SPARC-null mice.

Summary of Background data. IVD degeneration is associated with low back pain (LBP) and is accompanied by mechanical changes to the spine. SPARC is a protein that contributes to the functioning and maintenance of the extracellular matrix (ECM), with SPARC-null mice displaying accelerated IVD degeneration. TAK-242 is a toll-like …

Effects Of A 12-Week Vigorous Interval Training Intervention On Pro-Inflammatory Markers In Post-Operative Bariatric And Obese Participants, Brittany Rood

Masters Theses, 2010-2019

Increase prevalence of cardiovascular and other chronic diseases linked to inflammation has led to research on pro-inflammatory cytokines, like tumor necrosis factor - alpha (TNF-α) and lipoprotein-associated phospholipase A₂ (Lp-PLA₂), in attempt to define the relationship between chronic disease, inflammation, and obesity. PURPOSE: Examine the effect of twelve weeks of vigorous intensity interval training on pro-inflammatory markers in post-operative bariatric and obese participants. METHODS: 9 post-operative bariatric individuals [1 man, 8 women; Body mass index (BMI) = 34.23 ± 2.54 kg/m²], 12 obese individuals [5 men, 7 women; BMI=35.77 ± 1.67 kg/m^{2 …}

Does Acute Preprandial Exercise Modify Postprandial Inflammation After A High Fat Meal In Young And Older Adults?, William Wisseman

Masters Theses, 2010-2019

A single high-fat meal (HFM) can increase systemic inflammation (postprandial inflammation; PPI) and may be attenuated by recent exercise. However, the effect of preprandial exercise on PPI in older adults (OA) is not clear. Purpose: To determine if preprandial exercise attenuates PPI in YA and OA. Methods: 12 YA (23.3±3.9 years n= 5 M/7 F) and 12 OA (67.7±6 years, n= 8 M/4 F) completed two HFM challenges in a randomized order. During HFM alone, participants abstained from exercise 48 hours prior to the HFM session (except for the exercise session) and adhered to a 12 hour overnight …

Volumetric Muscle Loss: The Role Of Physical Activity And Autologous Repair On Force Recovery And Signaling Pathways, Richard Perry

Graduate Theses and Dissertations

Volumetric muscle loss affects both military and civilian persons. The hallmark of this injury is incomplete muscle regeneration, excessive fibrosis, and chronic inflammatory signaling resulting in permanent functional loss. Since permanent functional loss drastically reduces quality of life, many studies have been conducted to improve force recovery. Current scientific literature considers a repair strategy of either devitalized scaffolds infused with growth factors or viable tissue plus activating factors to be the more promising interventions for optimal force recovery. PURPOSE The purpose of this study is to incorporate autologous repair and physical activity and observe the effects of muscle force recovery …

Does Exercise Impact Gut Microbiota Composition In Men Receiving Androgen Deprivation Therapy For Prostate Cancer? A Single-Blinded, Two-Armed, Randomised Controlled Trial, Robert U. Newton, Claus T. Christophersen, Ciaran M. Fairman, Nicolas H. Hart, Dennis R. Taaffe, David Broadhurst, Amanda Devine, Raphael Chee, Colin I. Tang, Nigel Spry, Daniel A. Galvão

Research outputs 2014 to 2021

Introduction: A potential link exists between prostate cancer (PCa) disease and treatment and increased inflammatory levels from gut dysbiosis. This study aims to examine if exercise favourably alters gut microbiota in men receiving androgen deprivation therapy (ADT) for PCa. Specifically, this study will explore whether: (1) exercise improves the composition of gut microbiota and increases the abundance of bacteria associated with health promotion and (2) whether gut health correlates with favourable inflammatory status, bowel function, continence and nausea among patients participating in the exercise intervention.

Methods and analysis: A single-blinded, two-armed, randomised controlled trial will explore the influence of a …

Proprietary Milk Protein Concentrate Reduces Joint Discomfort While Improving Exercise Performance In Non-Osteoarthritic Individuals, Tim N. Ziegenfuss, Chad M. Kerksick, A. William Kedia, Jennifer Sandrock, Betsy Raub, Hector L. Lopez

Faculty Scholarship

Milk and dairy products are known to contain various bioactives with potential anti-inflammatory and immune modulating effects. Previous research has indicated that milk produced from hyperimmunized cows provided meaningful health benefits to individuals suffering from varying degrees of osteoarthritis and rheumatoid arthritis. PURPOSE: To examine the impact of a proprietary milk protein concentrate on joint discomfort and physical function, exercise performance, quality of life and various measures of affect. METHODS: Non-osteoarthritic men (42.5 ± 8.9 years, 176.7 ± 6.7 cm, 89.9 ± 11.5 kg, 28.8 ± 3.5 kg/m2, n = 30) and women (46.4 ± 9.6 years, 163.1 ± 8.2 …

Chronic Low Intensity Continuous And Interval Training Prevent Heart Failure-Related Coronary Artery Stiffness, An Ouyang

Theses and Dissertations--Kinesiology and Health Promotion

Heart failure (HF) induced by aortic pressure over-load is associated with increased coronary artery stiffness. Perivascular adipose tissue (PVAT) and advanced glycation end products (AGE) both promote arterial stiffness. However, the mechanisms by which coronary PVAT promotes arterial stiffness and the efficacy of exercise to prevent coronary stiffness are unknown. The present study hypothesized both chronic continuous and interval exercise training would prevent coronary artery stiffness associated with inhibition of PVAT secreted AGE. Yucatan mininature swine were divided into four groups: control-sedentary (CON), aortic-banded sedentary heart failure (HF), aortic-banded HF continuous exercise trained (HF+CONT), and aortic-banded HF interval exercise trained …

Genetic And Psychological Factors Interact To Predict Physical Impairment Phenotypes Following Exercise-Induced Shoulder Injury, Paul A. Borsa, Jeffrey J. Parr, Margaret R. Wallace, Samuel S. Wu, Yunfeng Dai, Roger B. Fillingim, Steven Z. George

Faculty Publications

Background: We investigated interactions between genetic and psychological factors in predicting shoulder impairment phenotypes. We hypothesized that pro-inflammatory genes would display stronger relationships compared with pain-related genes when combined with psychological factors for predicting phenotypic changes.
Subjects and methods: Altogether, 190 participants completed a 5-day experimental protocol. An experimental shoulder injury model was used to induce physical impairment, and a priori selected genetic (pain-related, pro-inflammatory) and psychological (anxiety, depressive symptoms, pain catastrophizing, fear of pain, kinesiophobia) factors were included as predictors of interest. Impairment phenotypes were injury-induced deficits in range of motion (ROM) and strength. After controlling for age, sex, …

An Investigation Into Fatigue Management: Effects Of Two Different Loading Protocols On Markers Of Inflammation And The Endocrine Response, Jake Bernards

Electronic Theses and Dissertations

The purposes of this dissertation were to 1) determine the effectiveness of the neutrophillymphocyte ratio (NLR) as an athlete monitoring tool in resistance training and 2) determine if repetition maximum or relative intensity loading scheme is superior in managing fatigue through the hormonal, inflammatory, and performances response throughout a 10-week periodized resistance training program. Results from the dissertation give merit to continued research regarding the use of NLR as a monitoring tool to help determine the degree of recovery. Furthermore, results from this dissertation lead to questioning the effectiveness of using a repetition maximum (RM) loading scheme within a periodized …

Par2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis In Mice, Shannon M. Jones, Adrien Mann, Kelsey Conrad, Keith Saum, David E. Hall, Lisa M. Mckinney, Nathan Robbins, Joel Thompson, Abigail D. Peairs, Eric Camerer, Katey J. Rayner, Michael Tranter, Nigel Mackman, A. Phillip Owens

Exercise and Sport Studies: Faculty Publications

Objective-PAR2 (protease-activated receptor 2)-dependent signaling results in augmented inflammation and has been implicated in the pathogenesis of several autoimmune conditions. The objective of this study was to determine the effect of PAR2 deficiency on the development of atherosclerosis. Approach and Resutle-PAR2 mRNA and protein expression is increased in human carotid artery and mouse aortic arch atheroma versus control carotid and aortic arch arteries, respectively. To determine the effect of PAR2 deficiency on atherosclerosis, male and female low-density lipoprotein receptor-deficient (Ldlr-/-) mice (8-12 weeks old) that were Par2+/+ or Par2-/- were fed a fat-and cholesterol-enriched diet for 12 or 24 weeks. …

Interactions Between Aerobic Exercise Volume, Academic Stress, And Immune Function, Teresa Wiczynski

Masters Theses & Specialist Projects

Many college students exercise individually or participate in collegiate and intramural sports in addition to fulfilling their stressful academic requirements. The combination of accumulated stress and vigorous exercise could result in an impaired immune system, prompting the onset of disease and absences in class and sports practice.

Twenty-six male and female participants aged 18 to 23 were recruited for this study. Over the course of an academic semester, participants completed weekly electronic surveys documenting stress levels, aerobic exercise, and symptoms related to upper respiratory tract infections. Participants were evaluated at four different time points (Baseline, Post-Midterm Exam, Baseline Reassessment, and …

Serum Tumor Necrosis Factor-Alpha Associates With Myocardial Oxygen Demand And Exercise Tolerance In Postmenopausal Women, Stephen J. Carter, David R. Bryan, William H. Neumeier, Stephen P. Glasser, Gary R. Hunter

International Journal of Exercise Science

International Journal of Exercise Science 11(2): 42-54, 2018. The functional implications of serum tumor necrosis factor-alpha (TNF-a), a marker of oxidative stress, on hemodynamic parameters at rest and during physical exertion are unclear. The aims of this investigation were to examine the independent associations of TNF-a on myocardial oxygen demand at rest and during submaximal exercise, while also evaluating the association of TNF-a on exercise tolerance. Forty, postmenopausal women, provided blood samples and completed a modified-Balke protocol to measure maximal oxygen uptake (VO_2max). Large artery compliance was measured by pulse contour analyses while rate-pressure product (RPP), an index …

Serum Tumor Necrosis Factor-Alpha Associates With Myocardial Oxygen Demand And Exercise Tolerance In Postmenopausal Women, Stephen J. Carter, David R. Bryan, William H. Neumeier, Stephen P. Glasser, Gary R. Hunter

Internal Medicine Faculty Publications

The functional implications of serum tumor necrosis factor-alpha (TNF-α), a marker of oxidative stress, on hemodynamic parameters at rest and during physical exertion are unclear. The aims of this investigation were to examine the independent associations of TNF-α on myocardial oxygen demand at rest and during submaximal exercise, while also evaluating the association of TNF-α on exercise tolerance. Forty, postmenopausal women, provided blood samples and completed a modified-Balke protocol to measure maximal oxygen uptake (VO_2max). Large artery compliance was measured by pulse contour analyses while rate-pressure product (RPP), an index of myocardial oxygen demand, was measured at rest …

Impact Of Aerobic Exercise On Monocyte Subset Receptor Expression And Macrophage Polarization, Anson M. Blanks

Theses and Dissertations

Atherosclerotic cardiovascular disease (CVD) is hallmarked by inflammatory immune activation, particularly by the induction of a response by monocytes. Classical (CD14⁺⁺CD16^-) are anti-inflammatory mediators under homeostatic conditions, while intermediate (CD14⁺⁺CD16⁺) and non-classical (CD14^LowCD16⁺⁺) monocytes promote inflammation following activation. Monocyte activation and functionality is dependent upon receptor expression and ligand production by a variety of cells, including monocytes. Alterations in the expression of surface receptors often have a direct impact upon monocyte function, such as the increased pro-inflammatory cytokine production in response to activation that accompanies elevated CD14 expression …

Lps-Induced Inos Mrna And The Pro-Apoptotic Signaling Pathway In Leukocytes Of Fit And Unfit Males, Tiffany M. Zuniga

Theses and Dissertations

Overexpression of the enzyme iNOS induces apoptotic cellular death by increasing indices of pro-inflammation and oxidative stress. Aerobic physical activity has been known to have anti- inflammatory benefits and reduce oxidative stress. Purpose: Therefore, this study aimed to examine the impact of aerobic fitness on LPS-induced iNOS mRNA expression and the relationship of this expression with indices of oxidative stress, pro-inflammation and apoptosis in isolated leukocytes. Methods: Whole blood samples from aerobically fit and unfit males were stimulated with and without LPS. Thereafter, iNOS mRNA expression and MDA, TNF-α and p53 concentrations were analyzed. Results: iNOS mRNA expression levels following …

Exercise-Induced Interleukin-6 And Metabolic Responses In Hot, Temperate, And Cold Conditions, Nicholas E. Dinan, Roksana B. Zak, Robert J. Shute, Terry Laursen, Matthew Bubak, D. Taylor La Salle, Matthew W.S. Heesch, Dustin R. Slivka

Journal of Human Performance in Extreme Environments

The purpose of this study was to determine the effects of exercise in hot, cold, and temperate environments on plasma interleukin-6 (IL-6). Eleven recreationally trained males (age = 25 ± 4 years, height = 178 ± 5 cm, weight = 79.4 ± 13.5 kg, body fat = 14.7 ± 3.6%, VO₂ peak = 54.6 ± 11.5 ml kg^-1 min^-1) performed a 1 hr cycling bout in hot (33 °C), cold (7 °C), and temperate (20 °C) environments at 60% of W_max followed by 3 hr of supine recovery in temperate conditions. Expired gases were measured …

Are Cardiovascular Disease Inflammatory Markers Elevated In Those With Nonspecific Chronic Musculoskeletal Pain Compared To Nonpain Case Controls?, Jeffrey Ray Tolley

Theses and Dissertations

CONTEXT: Recent studies have considered the role of inflammation in the development of both cardiovascular disease (CVD) and musculoskeletal conditions, such as rheumatoid arthritis. Studies suggest that inflammation plays a significant role in the development of cardiovascular disease. In conditions of chronic pain, as with rheumatoid arthritis, inflammation has also been noted through elevated levels of inflammatory markers. There are currently no studies that examine the possible connection between inflammatory markers related to increased risk of cardiovascular disease and nonspecific chronic musculoskeletal pain (NCMP). OBJECTIVE: The purpose of this study was to determine whether urinary levels of microalbumin (MA) and …

An Investigation Of The Relationship Between Intervertebral Disc Puncture, Inflammation, And Tissue Mechanics Using A Rat-Tail Model., Brigitte Laird

Theses and Dissertations (Comprehensive)

Introduction: The intervertebral disc (IVD) is composed of the annulus fibrosus (AF), which surrounds and contains the nucleus pulposus (NP). It is hypothesized that when the IVD becomes injured, in the case of IVD herniation, a localized innate immune response is initiated. Although the presence of pro-inflammatory cytokines in injured IVDs has been well documented, the extent to which inflammation affects the mechanical properties of the IVD remains poorly understood. The purpose of this study was to determine the effect of IVD damage (via puncture) and inflammation (via lipopolysaccharide (LPS) exposure) on the mechanical and structural properties of the IVD. …

Running Decreases Knee Intra-Articular Cytokine And Cartilage Oligomeric Matrix Concentrations: A Pilot Study, Robert D. Hyldahl, Alyssa Evans, Sunku Kwon, Sarah T. Ridge, Eric Robinson, J. Ty Hopkins, Matthew K. Seeley

Faculty Publications

Introduction Regular exercise protects against degenerative joint disorders, yet the mechanisms that underlie these benefits are poorly understood. Chronic, low-grade inflammation is widely implicated in the onset and progression of degenerative joint disease.

Purpose To examine the effect of running on knee intra-articular and circulating markers of inflammation and cartilage turnover in healthy men and women.

Methods Six recreational runners completed a running (30 min) and control (unloaded for 30 min) session in a counterbalanced order. Synovial fluid (SF) and serum samples were taken before and after each session. Cytokine concentration was measured in SF and serum using a multiplexed …

The Implications Of Different Types Of Diet And Exercise On Human Health, Bethanne C. Clayton

Masters Theses & Specialist Projects

There is need for enhanced prevention and treatment methods to combat sedentary lifestyle, obesity, and chronic disease by investigating the impact of specific exercise modalities and dietary factors on human health. The purposes of this study were: 1) to assess self-selected and perceived exercise intensity during High-Intensity Functional Training (HIFT) between males and females and to determine variables that predict self-selected exercise intensity (%VO2max) and/or perceived intensity (RPE) and 2) to investigate the impact of obesity on skeletal muscle metabolism in response to lipid oversupply by analyzing the responses of genes linked with fatty acid oxidation and inflammation in lean …