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Prospective Associations Of Homocysteine, Executive Function, And Depressive Symptoms, Peter J. Dearborn
Prospective Associations Of Homocysteine, Executive Function, And Depressive Symptoms, Peter J. Dearborn
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Associations of cardiovascular risk factors, cognitive performance, and depressive symptoms have been well established. However, the directionality of these associations as well as the specificity of these associations with respect to executive function are less clear. Additionally few studies have determined whether genetic risk factors, such as apolipoprotein-E4 (APOE-E4) genotype, and age moderate the associations of cardiovascular risk factors such as homocysteine with changes in depressive symptoms and how these associations may be mediated by cognitive performance. The primary aim of this study was to analyze the bidirectional associations of a full range of cognitive domains and symptoms of depression …