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Role Of Moa-1, An Anti-Phosphatase, And Apl-1, An App-Related Protein, In Morphogenesis And Mating Behavior In Caenorhabditis Elegans, Valerie C. Moscoso
Role Of Moa-1, An Anti-Phosphatase, And Apl-1, An App-Related Protein, In Morphogenesis And Mating Behavior In Caenorhabditis Elegans, Valerie C. Moscoso
Dissertations and Theses
Alzheimer's disease is a neurodegenerative disease that affects more than 30 million people globally. The disease is characterized by an accumulation of extracellular beta-amyloid peptide plaques and intracellular neurofibrillary tangles in the brain. The beta-amyloid peptide is derived from a larger precursor protein, the amyloid precursor protein (APP). Mutations in APP have been correlated with Alzheimer's disease. Due to the presence of two paralogues, APLP1 and APLP2, which have overlapping functions, the normal function of APP is difficult to elucidate. Knockout of the entire APP gene family in mice results in lethality and developmental defects, indicating that the APP gene …