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Neural Induction And Differentiation Of Stem Cells Using The Developmental Gene Pax7, Vijesh G. Vaghjiani
Neural Induction And Differentiation Of Stem Cells Using The Developmental Gene Pax7, Vijesh G. Vaghjiani
Theses : Honours
Neurodegenerative disorders are conditions that mainly affect the brain and the central nervous system (CNS). Each disease type is characterised by loss of function which results from death of a particular region. Interestingly enough, most of the time disease pathology is due to loss of specific cell types in the CNS. These pathological conditions have both high economic costs and social implications for society. To treat such conditions, either the lost cells must be replaced or the cells surrounding the damaged tissue must be induced to undergo repair to replace the lost cells. The former looks more achievable whereas the …
The Functional Significance Of Multiple Pax7 Isoforms, Chantel L. Burchill
The Functional Significance Of Multiple Pax7 Isoforms, Chantel L. Burchill
Theses : Honours
The Pax7 gene is critical for specification of both neurons in the mid-brain and skeletal muscle satellite cells. Several alternate transcripts are transcribed from the single gene. Previous studies have shown that the resultant alternate Pax7 isoforms differ in the structure of their paired domain (a DNA-binding domain that influences target gene selection), yet the functional significance of each isoform for specification of neurogenic and myogenic cell types remains unknown. Although previous studies have identified the presence of multiple alternate Pax7 transcripts in both neurogenic and myogenic cell lines, more research is necessary to understand the functional significance of the …