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Interacting Endogenous And Exogenous Rnai Pathways In Caenorhabditis Elegans., Rosalind C. Lee, Christopher M. Hammell, Victor R. Ambros
Interacting Endogenous And Exogenous Rnai Pathways In Caenorhabditis Elegans., Rosalind C. Lee, Christopher M. Hammell, Victor R. Ambros
Victor R. Ambros
C. elegans contains numerous small RNAs of ~21-24 nt in length. The microRNAs (miRNAs) are small noncoding RNAs produced by DCR-1- and ALG-dependent processing of self-complementary hairpin transcripts. Endogenous small interfering RNAs (endo-siRNAs), associated with ongoing silencing of protein-coding genes in normal worms, are produced by mechanisms that involve DCR-1 but, unlike miRNAs, also involve RDE-2, RDE-3, RDE-4, RRF-1, and RRF-3. The tiny noncoding (tncRNAs) are similar to endo-siRNAs in their biogenesis except that they are derived from noncoding sequences. These endo-siRNA- and tncRNA-based endogenous RNAi pathways involve some components, including DCR-1 and RDE-4, that are shared with exogenous RNAi, …