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Glucose And Acute Exercise Influence Factors Secreted By Circulating Angiogenic Cells In Vitro, Sarah Witkowski, Gayatri Guhanarayan, Rachel Burgess
Glucose And Acute Exercise Influence Factors Secreted By Circulating Angiogenic Cells In Vitro, Sarah Witkowski, Gayatri Guhanarayan, Rachel Burgess
Exercise and Sport Studies: Faculty Publications
Circulating angiogenic cells (CAC) influence vascular repair through the secretion of proangiogenic factors and cytokines. While CAC are deficient in patients with diabetes and exercise has a beneficial effect on CACs, the impact of these factors on paracrine secretion from CAC is unknown. We aimed to determine whether the in vitro secretion of selected cytokines and nitric oxide (NO) from CAC is influenced by hyperglycemia and acute exercise. Colonyforming unit CAC (CFU-CAC) were cultured from young active men (n = 9, 24 ± 2 years) at rest and after exercise under normal (5 mmol/L) and elevated (15 mmol/L) glucose. Preliminary …
Endothelial And Inflammatory Responses To Acute Exercise In Perimenopausal And Late Postmenopausal Women, Corinna Serviente, Lisa M. Troy, Maxine De Jonge, Daniel D. Shill, Nathan T. Jenkins, Sarah Witkowski
Endothelial And Inflammatory Responses To Acute Exercise In Perimenopausal And Late Postmenopausal Women, Corinna Serviente, Lisa M. Troy, Maxine De Jonge, Daniel D. Shill, Nathan T. Jenkins, Sarah Witkowski
Exercise and Sport Studies: Faculty Publications
Endothelial dysfunction and inflammation are characteristics of subclinical atherosclerosis and may increase through progressive menopausal stages. Evaluating endothelial responses to acute exercise can reveal underlying dysfunction not apparent in resting conditions. The purpose of this study was to investigate markers of endothelial function and inflammation before and after acute exercise in healthy low-active perimenopausal (PERI) and late postmenopausal (POST) women. Flow-mediated dilation (FMD), CD31+/CD42b- and CD62E+ endothelial microparticles (EMPs), and the circulating inflammatory factors monocyte chemoattractant protein 1 (MCP-1), interleukin 8 (IL-8), and tumor necrosis factor-α (TNF-α) were measured before and 30 min after acute exercise. Before exercise, FMD was …