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Extraction Method Development And In Vivo And In Vitro Toxicity Studies Of The Etiologic Agent Of Avian Vacuolar Myelinopathy, Faith Wiley
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Avian vacuolar myelinopathy (AVM) is a neurological disease affecting birds in the southeastern United States. The cause of the disease has not yet been determined but is believed to be a naturally produced toxin and is associated with aquatic vegetation. Current research on AVM is limited to in vivo studies utilizing whole tissue or vegetative samples. The objectives of this research were to develop extraction methods for isolating the putative AVM toxin from vegetative samples and to develop an in vitro bioassay for detection and study of the toxin. Samples of vegetation were collected from reservoirs known to be affected …