Digital Commons Network^™

Mixture Models With Grouping Structure: Retail Analytics Applications, Haidar Almohri

Wayne State University Dissertations

Growing competitiveness and increasing availability of data is generating tremendous interest in data-driven analytics across industries. In the retail sector, stores need targeted guidance to improve both the efficiency and effectiveness of individual stores based on their specific location, demographics, and environment. We propose an effective data-driven framework for internal benchmarking that can lead to targeted guidance for individual stores. In particular, we propose an objective method for segmenting stores using a model-based clustering technique that accounts for similarity in store performance dynamics. It relies on effective Finite Mixture of Regression (FMR) techniques for carrying out the model-based clustering with …

Modular Product Architecture’S Decisions Support For Remanufacturing-Product Service System Synergy, Johnson Adebayo Fadeyi

Wayne State University Dissertations

Remanufacturing is identified as the most viable product end-of-life (EOL) management strategy. However, about 80% of manufactured products currently end up as wastes. Besides other benefits, the product service system (PSS) could curtail the main bottlenecks to remanufacturing namely quantity, quality, recovery time of used product, and negative perception of remanufactured products. Therefore, the integration of PSS and remanufacturing has been increasingly recommended as an enhanced product offering. However, an integration that is informed by mathematical analysis is missing. Meanwhile, the variables that bolster the performance of PSS and remanufacturing are substantially influenced by product development (PD) decisions. Among the …

Study Of Probabilistic Characteristics Of Local Field Fluctuations In Isotropic Two Phase Composites: Conductivity Type Problems, David Ostberg

Wayne State University Dissertations

Probability distributions of electric …field and electric potential in two-phase particulate composite materials with spherical inclusions are found in the limit of small particle concentration. Additionally a method for the approximation of local fields within random statistically isotropic composites with a …finite number of …field ‡fluctuations which retain potentiality is presented and an approximate solution with the

variational principal for homogenization in statistical terms for three ‡fluctuations within one phase and a homogeneous second phase is found.

Ethanol Autoignition Modeling And Validation At Wide Ranges Of Mixture Temperatures, Pressures, And Equivalence Ratios, Antowan Zyada

Wayne State University Dissertations

A new ethanol detailed kinetic model with 107 species and 1795 reactions was developed by using the reaction mechanism generator (RMG) and a thorough reaction path analysis. The mechanism model was extensively evaluated against measured ignition delay times, laminar flame speeds, and time-resolved species concentrations. The ignition delay experiments were conducted at pressures of 15, 20, and 30 bar, a temperature range of 850 to 1000 K, and equivalence ratios of 0.5, 1.0 and 2.0 using an optically accessible rapid compression machine (RCM). The effect of oxygen concentration on the ignition delay at a fixed equivalence ratio was also measured …

Proactive Coordination In Healthcare Service Systems Through Near Real-Time Analytics, Seung Yup Lee

Wayne State University Dissertations

The United States (U.S.) healthcare system is the most expensive in the world. To improve the quality and safety of care, health information technology (HIT) is broadly adopted in hospitals. While EHR systems form a critical data backbone for the facility, we need improved 'work-flow' coordination tools and platforms that can enhance real-time situational awareness and facilitate effective management of resources for enhanced and efficient care. Especially, these IT systems are mostly applied for reactive management of care services and are lacking when they come to improving the real-time "operational intelligence" of service networks that promote efficiency and quality of …

Zwitterionic Polymer For Drug Delivery Applications, Yang Lu

Wayne State University Dissertations

This dissertation focuses on the applications of zwitterionic polymer materials in drug delivery. In one project, zwitterionic polymer was used to construct micelle surfactants. The zwitterionic micelles were found to have an ultralow critical micelle concentration (CMC). Potential mechanism for zwitterionic micelles achieving the ultralow CMC property has been studied. Based on the ultralow CMC feature, zwitterionic micelles were used to prepare a formulation of commercial antitumor drug docetaxel, and the resulting formulation showed excellent antitumor performance. In another project, zwitterionic polymer was used to modify protein drug insulin via conjugation reaction. Compared with current protein modification methods, such as …

Learning Convolutional Neural Network For Face Verification, Elaheh Rashedi

Wayne State University Dissertations

Convolutional neural networks (ConvNet) have improved the state of the art in many applications. Face recognition tasks, for example, have seen a significantly improved performance due to ConvNets. However, less attention has been given to video-based face recognition. Here, we make three contributions along these lines.

First, we proposed a ConvNet-based system for long-term face tracking from videos. Through taking advantage of pre-trained deep learning models on big data, we developed a novel system for accurate video face tracking in the unconstrained environments depicting various people and objects moving in and out of the frame. In the proposed system, we …

Integrated Strategies For Sustainable Wastewater-Based Algal Biofuel Production And Environmental Mitigation In The Us, Javad Roostaei

Wayne State University Dissertations

Integration of algae cultivation with wastewater treatment has received increasing interest as a cost-effective strategy for biofuel production. However, there has been no full assessment of algal biofuel production with wastewater on macro-scale by taking into account wastewater resources, land availability, CO2 emission resources, and geographic variation. This research addressed and evaluated the use of wastewater for algae cultivation, in terms of modeling and laboratory experiments. The first goal of this research was to develop a spatially explicit lifecycle model, by integrating life cycle assessment (LCA), and Geographic Information Systems (GIS) analysis, for the evaluation of the environmental and economic …

Reliability Analysis By Considering Steel Physical Properties, Wujun Si

Wayne State University Dissertations

Most customers today are pursuing engineering materials (e.g., steel) that not only can achieve their expected functions but also are highly reliable. As a result, reliability analysis of materials has been receiving increasing attention over the past few decades. Most existing studies in the reliability engineering field focus on developing model-based and data-driven approaches to analyze material reliability based on material failure data such as lifetime data and degradation data, without considering effects of material physical properties. Ignoring such effects may result in a biased estimation of material reliability, which in turn could incur higher operation or maintenance costs.

Recently, …

Engineering Hyaluronic Acid Carbon Nanotube Nanofibers: A Peripheral Nerve Interface To Electrically Stimulate Regeneration, Elisabeth M. Steel

Wayne State University Dissertations

Peripheral nerve injuries annually affect hundreds of thousands of people globally. Current treatments like the gold standard autograft and commercially available nerve guide conduits (NGC) are insufficient to repair long gap peripheral nerve injuries. NGCs can aid recovery but lack key microenvironment cues that promote nerve regeneration. We hypothesized that providing topographical, mechanical, and electrical guidance cues through a nanofibrous composite biopolymer would result in improved neuron growth metrics using an in vitro model. We embedded hydrophilic carbon nanotubes (CNT) within hyaluronic acid (HA) nanofibers by electrospinning. The aims of this study were (1) to define the topographical, nanomechanical, and …

Synthesis Of Volatile And Thermally Stable Aluminum Hydride Complexes And Their Use In Atomic Layer Deposition Of Metal Thin Films, Kyle Blakeney

Wayne State University Dissertations

The research discussed in this dissertation spans both synthetic inorganic and nanomaterials chemistry. Aluminum hydride complexes have been synthesized and characterized which are highly volatile and thermally stable and their potential as reducing agents for ALD of electropositive metal and metal-containing films was evaluated. A major discovery has been the deposition of aluminum metal films by thermal ALD using an aluminum dihydride complex supported by a simple amido-amine ligand (Chapters 2). Aluminum is the most electropositive element deposited by purely thermal ALD to date and represents a significant breakthrough for this field. This process may have important industrial applications and …

Data-Driven Modeling For Decision Support Systems And Treatment Management In Personalized Healthcare, Milad Zafar Nezhad

Wayne State University Dissertations

Massive amount of electronic medical records (EMRs) accumulating from patients and populations motivates clinicians and data scientists to collaborate for the advanced analytics to create knowledge that is essential to address the extensive personalized insights needed for patients, clinicians, providers, scientists, and health policy makers. Learning from large and complicated data is using extensively in marketing and commercial enterprises to generate personalized recommendations. Recently the medical research community focuses to take the benefits of big data analytic approaches and moves to personalized (precision) medicine. So, it is a significant period in healthcare and medicine for transferring to a new paradigm. …

A Data-Driven And Mixed Methods Analysis Of Automotive Retail Operations Management, Mark Allen Colosimo

Wayne State University Dissertations

The importance of effective retail operations management has never been more significant. Our research aims to expand the understanding for efficiency and dynamics of franchise outlets within retail networks with a focus on sales performance and profitability. The focus and contribution is the development of an actionable data analytics driven process by which automotive dealerships (retail outlets) can be analyzed to identify areas of opportunity for improvement. In general, automotive dealerships aim to sell product to make a profit, the manufacturer of the product/brand desires to sell vehicles to make a profit, and the customer desires to find a suitable …

Study Of Mri Signal In The Presence Of Discrete Spherical Magnetic Particles, Paul Kokeny

Wayne State University Dissertations

Simulating signal behavior in Magnetic Resonance imaging (MRI) is often a necessary step in being able to understand how signal relates to certain physiological parameters. One such parameter of interest in the body is magnetic susceptibility since it is related to iron content. The bulk magnetic susceptibility of an object is a property that describes how magnetized it becomes when placed in an external magnetic field. When the bulk susceptibility of an object arises from the presence of discrete magnetic inclusions, the MRI phase signal inside the object can no longer be determined analytically by assuming it has a continuous …

Analysis Of Micromixers To Minimize Scaling Effects On Reverse Osmosis Membranes, Jeremy Walker

Wayne State University Dissertations

ABSTRACT

ANALYSIS OF MICROMIXERS TO MINIMIZE SCALING EFFECTS ON REVERSE OSMOSIS MEMBRANES

by

Jeremy Walker

December 2018

Advisor: Dr. Shawn McElmurry

Major: Civil Engineering

Degree: Doctor of Philosophy

Structural elements, typically mesh spacers, are required between membrane leaves in spiral

wound elements to ensure flow through reverse osmosis (RO) modules. The standard diamond-shaped

mesh spacer results in non-ideal hydrodynamics that can lead to fouling, which ultimately reduces the

flux of water through the membrane and the operational life of the unit. Additionally, traditional mesh

feed spacers do not allow for reverse flow cleaning due to obstructed flow paths and, once …

Carbazole Based Multifunctional Dopamine Agonists And Related Molecules As Potential Symptomatic And Disease Modifying Therapeutic Agents For Parkinson’S Disease, Asma S.Mohamed Elmabruk

Wayne State University Dissertations

Parkinson’s disease (PD) is a progressive neurodegenerative disease that develops from gradual depletion of dopamine (DA) and dopaminergic neurons in the substantia nigra pars compacta (SNc) with the accumulation of intraneuronal proteinaceous matter named as Lewy bodies. The four cardinal symptoms associated with PD are tremor, rigidity, bradykinesia, and postural instability. Although the exact mechanism and etiology of PD are not fully understood, several factors have been implicated in the pathogenesis and progression of PD including protein aggregation, oxidative stress, mitochondrial dysfunction, environmental, and genetic factors.

The current therapy of Parkinson’s disease is categorized into four classes: levodopa, DA agonists, …

Remote Screening And Self-Monitoring For Vision Loss Diseases Based On Smartphone Applications, Hussein M. H. Khairallah

Wayne State University Dissertations

Remote Healthcare Monitoring System (RHMS) represents remote observing of patient’s well-being and providing therapeutic services. Sensors play an essential part in RHMs. They measure the physical parameters and give continuous information to health organizations, doctors. The presence of Smartphones and other portable devices have allowed us to utilize remote healthcare monitoring system for an assortment of structures. Also, Wireless Sensor Network (WSN) advances considered as one of the critical research factor healthcare application for enhancing the standard of living.

In this dissertation, I have presented three tiers operating in the remote healthcare monitoring system; the Body Area Network (BAN), the …

Maximum Recovery Of Mechanical Energy Through Work Integration: A Work Exchange Network Synthesis Approach, Aida Amini Rankouhi

Wayne State University Dissertations

Sustainable development has become a key concern in industries, largely due to natural resource depletion, global competition, and environmental pressure. Despite the efforts for sustainability improvement, still over a half of energy consumption is wasted in manufacturing sectors, where the chemical industry is responsible for an energy efficiency lower than it should be. Many attempts have been made to recover the thermal energy using heat integration techniques. Although process work is more expensive than process heat, no efficient solution has been studied to recover mechanical energy yet. In chemical plants, many process streams need to be pressurized or depressurized in …

Drug Delivery Strategies For The Treatment Of Advanced Lung Cancer And Various Lung Metastases, Elizabeth Bielski

Wayne State University Dissertations

Lung cancer remains the leading cause of cancer-related deaths in the United States. Secondary lung tumors metastasized from other cancer sites also remains highly prevalent, in which most metastatic tumors cannot be cured with existing therapies. Chemoresistance (multi drug resistance – MDR) that develops intrinsically or acquired is one of the key factors leading to fatality in these patients. MDR develops form a variety of resistance mechanisms that can occur consecutively or concurrently, therefore, making most current treatments unsuccessful. Current therapies have known to slow tumor growth, but rarely provide a cure. Immunotherapy has seen some promise, including the use …

Surfactants, Thermal And Surface Energy Effects On Emulsions’ Transport Properties: A Study Using Lattice Boltzmann Method, Wessam Falih Hasan

Wayne State University Dissertations

This work aims to provide an efficient Gunstensen LBM based CFD model, capable of solving complex problems related to droplets behavior in shear and parabolic flows.

Thermal conditions determine the outcome of the physical and transport properties of emulsions during their various processing phases. A better understanding of the intricate relationship between thermal, surfactants and hydrodynamics can help in the optimization of these processes during the production of emulsions. To investigate the outcome of coupling thermal, surfactants and hydrodynamics on emulsions behavior, a robust quasi-steady thermal-surfactants numerical scheme is presented and used here. To validate the model, the rheological behavior …

Identification Of Streptococcus Pyogenes Using Raman Spectroscopy, Ehsan Majidi

Wayne State University Dissertations

Despite the attention that Raman Spectroscopy has gained recently in the area of pathogen identification, the spectra analyses techniques are not well developed. In most scenarios, they rely on expert intervention to detect and assign the peaks of the spectra to specific molecular vibration. Although some investigators have used machine-learning techniques to classify pathogens, these studies are usually limited to a specific application, and the generalization of these techniques is not clear. Also, a wide range of algorithms have been developed for classification problems, however, there is less insight to applying such methods on Raman spectra. Furthermore, analyzing the Raman …

Experimental Validation Of An Integrated Guidance And Control System For Marine Surface Vessels, Anthony Composto

Wayne State University Dissertations

Autonomous operation of marine surface vessels is vital for minimizing human errors and providing efficient operations of ships under varying sea states and environmental conditions which is complicated by the highly nonlinear dynamics of marine surface vessels. To deal with modelling imprecision and unpredictable disturbances, the sliding mode methodology has been employed to devise a heading and a surge displacement controller. The implementation of such a controller necessitates the availability of all state variables of the vessel. However, the measured signals in the current study are limited to the global X and Y positioning coordinates of the boat that are …

Channel Fading Statistics For Real-Time Data Transmission In Emergency Call Systems And Unmanned Aerial Systems, Yunrui Li

Wayne State University Dissertations

The Third Generation Partnership Project (3GPP) selected an in-band modem to transmit emergency data over cellular voice channel for the European Union emergency call (eCall) system. However, the road test results presented by the Harmonized eCall European Pilot project showed that the success rate of data delivery was only 71%, indicating that there is significant potential to improve its performance.

In this dissertation, a testbed is designed for the eCall system that satisfies the 3GPP TS 26.267/268/269 standards. A method is proposed to measure the power of the received signal that passes through the in-band channel. Experiments are performed with …

Detectability Of Fuzzy Discrete Event Systems, Ahmed Mekki

Wayne State University Dissertations

Dynamic systems that can be modeled in terms of discrete states and a synchronous events are known as discrete event systems (DES). A DES is defined in terms of states, events, transition dynamics, and initial state. Knowing the system’s state is crucial in many applications for certain actions (events) to be taken. A DES system is considered a fuzzy discrete event system (FDES) if its states and events are vague in nature; for such systems, the system can be in more than one state at the same time with different degrees of possibility (membership). In this research we introduce a …

An Agile Quality Management System For Laboratory Developed Tests, Rita D'Angelo

Wayne State University Dissertations

ABSTRACT

AN AGILE QUALITY MANAGEMENT SYSTEM FOR LABORATORY DEVELOPED TESTS

By

RITA D’ANGELO

MAY 2017

Advisor: Dr. Ratna Babu Chinnan

Major: Industrial & Systems Engineering

Degree: Doctor of Philosophy Statement of the Problem: We explore the 2014 draft guidance by the FDA entitled Framework for Regulatory Oversight of Laboratory Developed Tests (LDT) extended from the medical device industry and discuss how these requirements may be applicable to laboratory medicine. We introduce terms, definitions and provide a call for action for leaders to prepare for the potential adherence to regulatory requirements and explore if compliance was achievable in a laboratory environment …

Enhancing Set-Based Design To Engineer Resilience For Long-Lived Systems, Gregory Hartman

Wayne State University Dissertations

At the heart of Set-Based Design is the concept that down-select decisions are deferred until sufficient information is available to make a decision, i.e., a set of possible solutions is maintained. Due to the extended service lives of many of our current and future systems, the horizon for accurately predicting the system’s requirement is shorter than the service life, so the needed information to down-select to a single optimized solution is unavailable at the time of fielding. Set-Based Design can, however, be extended to explicitly carry a set of possible solutions past the point of the initial fielding of the …

Influential Factors In Consumer's Adoption Of Innovative Products, Mahdokht Kalantari

Wayne State University Dissertations

This dissertation addresses the challenges involved with the process of diffusion of innovations in the contexts of innovative educational materials and technological innovations.

Chapters 2 and 3 discuss building and using Online Brand Communities (OBCs) to disseminate innovative math educational materials. OBCs are known to be important platforms where consumers can communicate with the brand as well as other consumers. Through the effective use of these platforms, brands could accelerate the process of diffusion of their innovations. However, OBCs will not survive if consumers do not get engaged and participate in these communities. The purpose of this section of the …

Design Of Dna Strand Displacement Based Circuits, Aby Konampurath George

Wayne State University Dissertations

DNA is the basic building block of any living organism. DNA is considered a popular candidate for future biological devices and circuits for solving genetic disorders and several other medical problems. With this objective in mind, this research aims at developing novel approaches for the design of DNA based circuits. There are many recent developments in the medical field such as the development of biological nanorobots, SMART drugs, and CRISPR-Cas9 technologies. There is a strong need for circuits that can work with these technologies and devices. DNA is considered a suitable candidate for designing such circuits because of the programmability …

Venous Thromboembolism (Vte) Harm Measurement And Risk Assessment In Real-Time Using Electronic Health Records(Ehr), Seyed Mani Marashi

Wayne State University Dissertations

Venous Thromboembolism (VTE) is a deadly disease and is considered as one of the top reasons for avoidable hospital deaths in the United States and around the world. Patients who survive this disease often must face life-long complications such as Post-thrombotic syndrome (PTS), Chronic thromboembolic pulmonary hypertension (CTPH), etc. Therefore, it is important to monitor and reduce the number of VTE instances in hospitals. This study shows how Electronic Health Records (EHRs) can be utilized to achieve this goal.

First, a new near real-time VTE harm measurement model was developed. Not only the developed model can deliver near real-time results, …