Digital Commons Network^™

Multi Well Uni-Axial Stretch Injury Device, Mridusmita Choudhury

Theses

Most diffuse brain injury is the result of uni-axial stretch of brain axons in traumatic brain injury. Traumatic injury to axons throughout the brain and is believed to be a major cause for coma, and other complications. Diffuse axonal injury is mostly multi-focal and appears throughout the deep cortical and sub-cortical regions.

Several models have tried to replicate this phenomenon. Previous models, like the Penn model, have lower throughput as they conduct experiments on one well at a time, and it has lower reproducibility as well. The other problem with these models is that they are not very user friendly, …