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Porcine Neonatal Heart Extracellular Matrix As A Regeneration Platform, Karla Perez
Porcine Neonatal Heart Extracellular Matrix As A Regeneration Platform, Karla Perez
Bioengineering Dissertations
Each year, an estimated 620,000 Americans have new heart attack and suffer from myocardial infarction (MI) that results in massive heart cell death and decrease in heart function. Various therapeutic strategies, such as pharmacological treatments and reperfusion strategies, have greatly improved short-term MI survival. However, these strategies do not restore normal cardiac function due to the permanent loss of cardiomyocytes. As a promising strategy, cardiac cell therapy delivers repairing cells to damaged areas (scar tissues) to revitalize the infracted heart. However, a key challenge in cardiac cell therapy, i.e. the extremely low survival and engraftment rate of transplanted cells, must …
Biomechanical Studies Of Developing Zebrafish Heart In-Vivo, Nabid Salehin
Biomechanical Studies Of Developing Zebrafish Heart In-Vivo, Nabid Salehin
Bioengineering Dissertations
The heart is an electrically controlled mechanical pump that provides the cardiac output required by the body to function properly and flexibly adapts to changing demand and working conditions. In vertebrate embryos, the heart is the first organ that starts functioning and the function is initiated well before structural organogenesis is complete, with its early mechanical function affecting its own development. During development, the heart transforms from a valveless linear peristaltic tube into a multi-chambered pulsatile pump with blood flow regulating valves while continuing to serve the metabolic needs of the embryo. The zebrafish has emerged as a popular model …