Digital Commons Network^™

Dna Electrophoretic Migration Patterns Change After Exposure Of Jurkat Cells To A Single Intense Nanosecond Electric Pulse, Stefania Romeo, Luigi Zeni, Maurizio Sarti, Anna Sannino, Maria Rosaria Scarfi, P. Thomas Vernier, Olga Zeni

Bioelectrics Publications

Intense nanosecond pulsed electric fields (nsPEFs) interact with cellular membranes and intracellular structures. Investigating how cells respond to nanosecond pulses is essential for a) development of biomedical applications of nsPEFs, including cancer therapy, and b) better understanding of the mechanisms underlying such bioelectrical effects. In this work, we explored relatively mild exposure conditions to provide insight into weak, reversible effects, laying a foundation for a better understanding of the interaction mechanisms and kinetics underlying nsPEF bio-effects. In particular, we report changes in the nucleus of Jurkat cells (human lymphoblastoid T cells) exposed to single pulses of 60 ns duration and …

Analysis Of Engineering Content With Technology Education Programs, Todd D. Fantz, Petros J. Katsioloudis

STEMPS Faculty Publications

No abstract provided.

A Google Earth-Based Framework For Visualization Of The Chesapeake Bay Operational Forecast System, Gary Lawson

Computational Modeling & Simulation Engineering Theses & Dissertations

For the persons who live near and travel the waters of the Chesapeake Bay, the data provided by the Chesapeake Bay Operational Forecast System (CBOFS) is invaluable. The information provided includes measurements and forecasts of surface wind velocity, water current velocity, salinity levels, water level, and temperature. Currently, this information is freely available on the CBQ_FS website hosted by the National Oceanographic and Atmospheric Administration (NOAA). It is offered as Nowcast, measured data, and Forecast data and is visualized using 2D images which describe a subset of the data in an easy to read chart. However, if the data were …

Using Modeling And Simulation To Improve Oral Health Services Delivery In Hampton Roads, Virginia, Mohammad J. Alzahrani

Health Services Research Dissertations

The purpose of this study is to examine the system performance in delivering oral health services in a public health district based on the Conceptual Framework to Measure Performance of the Public Health System (PHS). Using modeling and simulation, a predictive model based on the conceptual framework dimensions: mission, structural capacity, processes, and outcomes was developed to predict the performance of public health district in delivering oral health services.

This is a retrospective longitudinal study. The main objective of this study is to use a modeling and simulation approach to predict the performance of public health district dental clinic in …

Automatic High-Fidelity 3d Road Network Modeling, Jie Wang

Computational Modeling & Simulation Engineering Theses & Dissertations

Many computer applications such as racing games and driving simulations frequently make use of 3D high-fidelity road network models for a variety of purposes. However, there are very few existing methods for automatic generation of 3D realistic road networks, especially for those in the real world. On the other hand, vast road network GIS data have been collected in the past and used by a wide range of applications, such as navigation and evaluation. A method that can automatically produce 3D high-fidelity road network models from 2D real road GIS data will significantly reduce both the labor and time needed …

Steel Angle Section Members Under Combined Axial Load And Unsymmetric Bending, Maheshchandra Rajasekharan Phanibhushan

Civil & Environmental Engineering Theses & Dissertations

This thesis presents the outcome of an investigation into the experimental and theoretical behavior of steel angle section members under combined axial load and unsymmetric bending. Tests are conducted on a series of six angle section members provided with biaxial pinned-end boundaries about the cross-sectional non-principal axes. The end bending moments and axial load are applied in a quasi-static manner until the member load-carrying capacity is reached. The experimental load-deflection and load-strain curves are recorded. The theoretical analysis is based on a system of both elastic as well as materially nonlinear differential equations. The equations were solved using an iterative …

Excitation-Induced Ge Quantum Dot Growth On Si(100)-2x1 By Pulsed Laser Deposition, Ali Oguz Er

Physics Theses & Dissertations

Self-assembled Ge quantum dots (QD) are grown on Si(100)-(2×1) with laser excitation during growth processes by pulsed laser deposition (PLD). In situ reflection-high energy electron diffraction (RHEED) and post-deposition atomic force microscopy (AFM) are used to study the growth dynamics and morphology of the QDs. A Q-switched Nd:YAG laser (λ = 1064 nm, 40 ns pulse width, 5 J/cm² fluence, and 10 Hz repetition rate) were used to ablate germanium and irradiate the silicon substrate. Ge QD formation on Si(100)-(2×1) with different substrate temperatures and excitation laser energy densities was studied. The excitation laser reduces the epitaxial growth temperature …

A Systemic Approach To Next Generation Infrastructure Data Elicitation And Planning Using Serious Gaming Methods, Ersin Ancel

Engineering Management & Systems Engineering Theses & Dissertations

Infrastructure systems are vital to the functioning of our society and economy. However, these systems are increasingly complex and are more interdependent than ever, making them difficult to manage. In order to respond to increasing demand, environmental concerns, and natural and man-made threats, infrastructure systems have to adapt and transform. Traditional engineering design approaches and planning tools have proven to be inadequate when planning and managing these complex socio-technical system transitions. The design and implementation of next generation infrastructure systems require holistic methodologies, encompassing organizational and societal aspects in addition to technical factors. In order to do so, a serious …

Perfectly Matched Layer Absorbing Boundary Conditions For The Discrete Velocity Boltzmann-Bgk Equation, Elena Craig

Mathematics & Statistics Theses & Dissertations

Perfectly Matched Layer (PML) absorbing boundary conditions were first proposed by Berenger in 1994 for the Maxwell's equations of electromagnetics. Since Hu first applied the method to Euler's equations in 1996, progress made in the application of PML to Computational Aeroacoustics (CAA) includes linearized Euler equations with non-uniform mean flow, non-linear Euler equations, flows with an arbitrary mean flow direction, and non-linear clavier-Stokes equations. Although Boltzmann-BGK methods have appeared in the literature and have been shown capable of simulating aeroacoustics phenomena, very little has been done to develop absorbing boundary conditions for these methods. The purpose of this work was …

A Methodology To Repair Or Deorbit Leo Satellite Constellations, Goksel Gurgenburan

Mechanical & Aerospace Engineering Theses & Dissertations

In this thesis, mitigation of space debris is addressed by examining an approach for repair or de-orbit of a specific population of non-functional Low Earth Orbit (LEO) satellites. Basic orbital mechanics propagation of the orbits was used as the process for computing a solution to the time and intercept position for the targeted satellites. Optimal orbital maneuvers to reach the target satellites from a pre-established orbit were also considered. In this way minimum ΔV budget, rendezvous time and mass budgets were managed. The Clohessy-Wiltshire Equations and two-impulsive rendezvous maneuvers were used to determine the orbital path of a chase satellite …

Interface Circuit For A Multiple-Beam Tuning-Fork Gyroscope With High Quality Factors, Ren Wang

Mechanical & Aerospace Engineering Theses & Dissertations

This research work presents the design, theoretical analysis, fabrication, interface electronics, and experimental results of a Silicon-On-Insulator (SOI) based Multiple-Beam Tuning-Fork Gyroscope (MB-TFG). Based on a numerical model of Thermo-Elastic Damping (TED), a Multiple-Beam Tuning-Fork Structure (MB-TFS) is designed with high Quality factors (Qs) in its two operation modes. A comprehensive theoretical analysis of the MB-TFG design is conducted to relate the design parameters to its operation parameters and further performance parameters. In conjunction with a mask that defines the device through trenches to alleviate severe fabrication effect on anchor loss, a simple one-mask fabrication process is employed to implement …

A Variable Acceleration Calibration System, Thomas H. Johnson

Mechanical & Aerospace Engineering Theses & Dissertations

A variable acceleration calibration system that applies loads using gravitational and centripetal acceleration serves as an alternative, efficient and cost effective method for calibrating internal wind tunnel force balances. Two proof-of-concept variable acceleration calibration systems are designed, fabricated and tested. The NASA UT-36 force balance served as the test balance for the calibration experiments. The variable acceleration calibration systems are shown to be capable of performing three component calibration experiments with an approximate applied load error on the order of 1% of the full scale calibration loads. Sources of error are indentified using experimental design methods and a propagation of …

A Wind Tunnel Technique For The Identification Of Ship Airwake/Rotor Downwash Coupling, Stargel R. Doane

Mechanical & Aerospace Engineering Theses & Dissertations

A wind tunnel study is performed to analyze the interaction between ship airwakes and helicopter rotor downwash. This interaction is of interest to naval aviators and researchers as this phenomenon is thought to limit helicopter flight envelopes and increase the overall difficulty of maritime rotorcraft operations. In this study, a 1/50th scale simplified naval frigate model and appropriately scaled rotor model are used for all experimental work. A rotor thrust survey was conducted in the immediate vicinity of the landing deck. Two dimensional and stereo particle image velocimetry surveys and rotor thrust measurements with various rotor and ship configurations were …

A Framework For Dynamic Traffic Monitoring Using Vehicular Ad-Hoc Networks, Mohammad Hadi Arbabi

Computer Science Theses & Dissertations

Traffic management centers (TMCs) need high-quality data regarding the status of roadways for monitoring and delivering up-to-date traffic conditions to the traveling public. Currently this data is measured at static points on the roadway using technologies that have significant maintenance requirements. To obtain an accurate picture of traffic on any road section at any time requires a real-time probe of vehicles traveling in that section. We envision a near-term future where network communication devices are commonly included in new vehicles. These devices will allow vehicles to form vehicular networks allowing communication among themselves, other vehicles, and roadside units (RSUs) to …

Using The Web Infrastructure For Real Time Recovery Of Missing Web Pages, Martin Klein

Computer Science Theses & Dissertations

Given the dynamic nature of the World Wide Web, missing web pages, or "404 Page not Found" responses, are part of our web browsing experience. It is our intuition that information on the web is rarely completely lost, it is just missing. In whole or in part, content often moves from one URI to another and hence it just needs to be (re-)discovered. We evaluate several methods for a \justin- time" approach to web page preservation. We investigate the suitability of lexical signatures and web page titles to rediscover missing content. It is understood that web pages change over time …

Ultrafast Electron Diffraction Study Of The Dynamics Of Antimony Thin Films And Nanoparticles, Mahmoud Abdel-Fattah

Electrical & Computer Engineering Theses & Dissertations

The ultrafast fast phenomena that take place following the application of a 120 fs laser pulse on 20 nm antimony thin films and 40 nm nanoparticles were studied using time-resolved electron diffraction. Samples are prepared by thermal evaporation, at small thickness (< 10 nm) antimony nanoparticles form while at larger thicknesses we get continuous thin films.

The samples are annealed and studied by static heating to determine their Debye temperatures, which were considerably less than the standard value. The thermal expansion under static heating also yielded the expansion coefficient of the sample material. Nanoparticle samples gave a very accurate thermal expansion coefficient (11 × 10^-6 K^-1).

Ultrafast time resolved electron diffraction …

Statistical Optimizations Of Muscle Action Potentials Based On Modeling And Analysis Of Ion Channel Dynamics, Gyutae Kim

Electrical & Computer Engineering Theses & Dissertations

An Electromyogram (EMG) is an electrical signal, which is measured from a skeletal muscle during voluntary and involuntary contractions. EMGs are useful in interpreting pathological states of the musculoskeletal system. In particular, EMGs offer valuable information concerning the timing of muscular activity and its relative intensity. Various EMG models have developed with many different purposes from a pure mathematical model to a pattern structure model [17,46]. Sophisticated EMG models are necessary to examine the effects of small changes in muscular morphology and activities [46]. Due to the crucial importance of EMG models, all factors in the model should be precise …

Improving The Efficiency Of Organic Solar Cells By Varying The Material Concentration In The Photoactive Layer, Kevin Anthony Latimer

Electrical & Computer Engineering Theses & Dissertations

Polymer-fullerene bulk heterojunction solar cells have been a rapidly improving technology over the past decade. To further improve the relatively low energy conversion efficiencies of these solar cells, several modifications need to be made to the overall device structure. Emerging technologies include cells that are fabricated with interfacial layers to facilitate charge transport, and tandem structures are being introduced to harness the absorption spectrum of polymers with varying bandgap energies.

When new structures are implemented, each layer of the cell must be optimized in order for the entire device to function efficiently. The most volatile layer of these devices is …

The Tracking Performance Of Distributed Recoverable Flight Control Systems Subject To High Intensity Radiated Fields, Rui Wang

Electrical & Computer Engineering Theses & Dissertations

It is known that high intensity radiated fields (HIRF) can produce upsets in digital electronics, and thereby degrade the performance of digital flight control systems. Such upsets, either from natural or man-made sources, can change data values on digital buses and memory and affect CPU instruction execution. HIRF environments are also known to trigger common-mode faults, affecting nearly-simultaneously multiple fault containment regions, and hence reducing the benefits of n-modular redundancy and other fault-tolerant computing techniques. Thus, it is important to develop models which describe the integration of the embedded digital system, where the control law is implemented, as well …

Evaluation Of Delivery Conditions For Cutaneous Plasmid Electrotransfer Using A Multielectrode Array, Bernadette Ferraro, Loree C. Heller, Yolmari L. Cruz, Siqi Guo, Amy Donate, Richard Heller

Bioelectrics Publications

Electroporation (EP) is a simple in vivo method to deliver normally impermeable molecules, such as plasmid DNA, to a variety of tissues. Delivery of plasmid DNA by EP to a large surface area is not practical because the distance between the electrode pairs, and therefore the applied voltage, must be increased to effectively permeabilize the cell membrane. The design of the multielectrode array (MEA) incorporates multiple electrode pairs at a fixed distance to allow for delivery of plasmid DNA to the skin, potentially reducing the sensation associated with in vivo EP. In this report, we evaluate the effects of field …

Proceedings, Msvscc 2011, Old Dominion University, Department Of Modeling, Simulation & Visualization Engineering, Old Dominion University, Virginia Modeling, Analysis & Simulation Center

Modeling, Simulation and Visualization Student Capstone Conference

Proceedings of the 5th Annual Modeling, Simulation & Visualization Student Capstone Conference held on April 14, 2011 at VMASC in Suffolk, Virginia. 186 pp.

Section Abstracts: Biomedical And General Engineering

Virginia Journal of Science

Abstracts of the Biomedical and General Engineering Section for the 89th Annual Meeting of the Virginia Academy of Science, May 25-27, 2011, University of Richmond, Richmond VA.

Section Abstracts: Astronomy, Mathematics And Physics With Materials Science

Virginia Journal of Science

Abstracts for the Astronomy, Mathematics, and Physics with Materials Science Section for the 89th Annual Meeting of the Virginia Academy of Science, May 25-27, 2011, University of Richmond, Richmond VA.

Section Abstracts: Aeronautical And Aerospace Sciences

Virginia Journal of Science

Abstracts of the Aeronautical and Aerospace Sciences Section for the 89th Annual Meeting of the Virginia Academy of Science, May 25-27, 2011, University of Richmond, Richmond, Virginia.

Evaluation Of A Novel Non-Penetrating Electrode For Use In Dna Vaccination, Amy Donate, Domenico Coppola, Yolmari Cruz, Richard Heller

Bioelectrics Publications

Current progress in the development of vaccines has decreased the incidence of fatal and non-fatal infections and increased longevity. However, new technologies need to be developed to combat an emerging generation of infectious diseases. DNA vaccination has been demonstrated to have great potential for use with a wide variety of diseases. Alone, this technology does not generate a significant immune response for vaccination, but combined with delivery by electroporation (EP), can enhance plasmid expression and immunity. Most EP systems, while effective, can be invasive and painful making them less desirable for use in vaccination. Our lab recently developed a non-invasive …

Examination Timetabling With Mathematical Programming An Application In Turkish Air Force Academy, Emrah Koksalmis

Engineering Management & Systems Engineering Theses & Dissertations

The focus of this thesis is the educational timetabling problem, which is a very challenging problem to solve especially with a high number of the departments, branches, classes, and students. Due to the large scale of educational timetabling problems and preferences of the stakeholders, it is almost impossible to form a general model that solves all of the timetabling problems in the literature. This resulted in the need to develop and employ specific models for specific institutions.

The purpose of this study is to develop a mathematical programming model that solves the examination timetabling problem in Turkish Air Force Academy …

Random Keys Genetic Algorithms Scheduling And Rescheduling Systems For Common Production Systems, Elkin Rodriguez-Velasquez

Engineering Management & Systems Engineering Theses & Dissertations

The majority of scheduling research deals with problems in specific production environments with specific objective functions. However, in many cases, more than one problem type and/or objective function exists, resulting in the need for a more generic and flexible system to generate schedules. Furthermore, most of the published scheduling research focuses on creating an optimal or near optimal initial schedule during the planning phase. However, after production processes start, circumstances like machine breakdowns, urgent jobs, and other unplanned events may render the schedule suboptimal, obsolete or even infeasible resulting in a "rescheduling" problem, which is typically also addressed for a …

A Hybrid Lehmer Code Genetic Algorithm And Its Application On Traveling Salesman Problems, Jun Zhang

Engineering Management & Systems Engineering Theses & Dissertations

Traveling Salesman Problems (TSP) is a widely studied combinatorial optimization problem. The goal of the TSP is to find a tour which begins in a specific city, visits each of the remaining cities once and returns to the initial cities such that the objective functions are optimized, typically involving minimizing functions like total distance traveled, total time used or total cost.

Genetic algorithms were first proposed by John Holland (1975). It uses an iterative procedure to find the optimal solutions to optimization problems.

This research proposed a hybrid Lehmer code Genetic Algorithm. To compensate for the weaknesses of traditional genetic …

Optimization Models And Approximate Algorithms For The Aerial Refueling Scheduling And Rescheduling Problems, Sezgin Kaplan

Engineering Management & Systems Engineering Theses & Dissertations

The Aerial Refueling Scheduling Problem (ARSP) can be defined as determining the refueling completion times for fighter aircrafts (jobs) on multiple tankers (machines) to minimize the total weighted tardiness. ARSP can be modeled as a parallel machine scheduling with release times and due date-to-deadline window. ARSP assumes that the jobs have different release times, due dates, and due date-to-deadline windows between the refueling due date and a deadline to return without refueling. The Aerial Refueling Rescheduling Problem (ARRP), on the other hand, can be defined as updating the existing AR schedule after being disrupted by job related events including the …

A Study Of The Correlation Of Sub-Aqueous Beach Profile Change And The Coastal Storm Impulse (Cosi) Parameter, Kevin Bryan Conner

Civil & Environmental Engineering Theses & Dissertations

The Coastal Storm Impulse (COSI) parameter is a recently developed storm-strength parameter that was first introduced at the San Diego, California International Conference of Coastal Engineering in 2006 (ICCE) and further examined in 2008 at the ICCE in Hamburg, Germany. This new parameter used the principles of conservation of horizontal momentum to combine storm characteristics such as surge, wave dynamics, currents, and duration into a relative scale used to classify and measure storm response and impacts. The resultant classification system was intended to evaluate potential coastal erosion and the associated loss of coastal infrastructure, as well as provide a storm …