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Wayne State University Dissertations
Bone, Calcium Phosphate, Crystallography, Hydroxyapatite Collagen Composite, Mechanical Properties, Polarized Light Microscopy
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Enhancing The Mechanical Properties Of A Hydroxyapatite-Collagen Bone Surrogate, Richard Franz Banglmaier
Enhancing The Mechanical Properties Of A Hydroxyapatite-Collagen Bone Surrogate, Richard Franz Banglmaier
Wayne State University Dissertations
The synthesis of biomimetic hydroxyapatite-collagen composites is desirable from the perspective of graft elimination and load-bearing support when treating damaged or diseased bone. Bone is an organized network of carbonated hydroxyapatite mineralized collagen, whose strength and toughness is dependent on the organized array of mineralized collagen fibers that align with applied physiologic stresses. The apatitic calcium phosphate phase, hydroxyapatite, is promising for the biomimetic mineralization of collagen. Hydroxyapatite-collagen composites are osteoconductive and resorbable. However, the mechanical properties of these composites are one or more orders of magnitude less than bone. The aim of this study was to produce a bone-like …