Digital Commons Network^™

Engineering An Injectable Hydrogel With Self-Assembling 3d Vasculature, Kendyl Cohn

Master's Theses

This research developed methods for culturing self-assembling capillaries in an injectable gel as a potential method for vascularizing tissue-on-a-chip models to mimic physiological drug delivery. Additionally, a mathematical model was developed as a tool for understanding nutrient delivery and comparison of potential delivery systems. Organs-on-a-chip provide novel platforms for studying biology and physiology in 3D, allow exploration of tissue engineering on a manageable scale, and serve as models for drug screening and drug-delivery testing.

Methods were first developed for co-culture of endothelial cells and fibroblasts (3T3s or HDFs) in 2D, evaluating culture time, seeding density and ratio of HUVECs and …

Implementation And Efficiency Of Electric Motors In Lygus Bug Vacuums For Strawberries, Adam J. Rantz

Master's Theses

Further automation of the agricultural industry and an increase in organic fruit production are needed to address labor shortage and increased demand. The move to an autonomous bug vacuum is easier if the equipment is electric, and not powered by a tractor’s PTO (power take-off) shaft. The main objective of this project was to design a set of lygus bug vacuums to go on a robot that meets industry standards while using electric power instead of hydraulic. The frame of the vacuum was designed using the industry standard. While hydraulic systems have been a very effective power source for vacuums …

Feasibility And Characterization Of Leak-Tight Single-Track Thin Walls Produced By Laser Powder Bed Fusion In 316l Stainless Steel, Peyton J. Archibald

Master's Theses

This thesis explores the optimization of process parameters for producing single-track thin walls using Laser Powder Bed Fusion (LPBF) additive manufacturing. Using two different coupon designs, the study assesses the feasibility of creating the thinnest possible leak-tight structures within LPBF and evaluating their mechanical properties, including burst pressure and modulus of elasticity under pressure loads. A series of experimental iterations were conducted, varying laser power and laser speed to identify optimal conditions. The findings indicate that a narrow range of process parameters can produce consistently leak-tight thin walls. The results contribute to understanding how to achieve high quality, reliable thin …

Synthesis Of Geopolymer Using Coal Fly Ash And Corn Stover, Anu Paneru

Master's Theses

The development of each nation is dependent on its infrastructure, and nations are competing with others in infrastructure, especially in the construction of roadways, since they play a vital role in the economic and social development of the nation. The conventional materials used for road construction are cement and asphalt, which pose significant environmental challenges. This thesis explores the potential of fly ash (FA) and corn stover (CS) in synthesizing geopolymer, as an alternative material for the construction of roads. The study examines the impact of FA and CS percentages and the particle sizes of CS on the compressive strength, …

Comparing Proliferation Rates And Collagen Production Of Cells Treated With Cuhars, Katie Elizabeth Mckenzie

Master's Theses

Cartilage is the padding in joints that protects the bones and aids in motion. Problems with the cartilage in the knee can be caused by mechanical damage or diseases like osteoarthritis. Chondrocytes make cartilage. The objective of this study is to determine the doubling time of chondrocytes per passage. I also want to determine the base amount of collagen-II created by chondrocytes as they age. I also want to determine how long it takes CuHARS to break down in different cell medias. Chondrocytes, human dermal fibroblasts, and CRL 2303 cells were grown and cultured for over a year. During that …

Generalized Model To Enable Zero-Shot Imitation Learning For Versatile Robots, Yongshuai Wu

Master's Theses

The rapid advancement in Deep Learning (DL), especially in Reinforcement Learning (RL) and Imitation Learning (IL), has positioned it as a promising approach for a multitude of autonomous robotic systems. However, the current methodologies are predominantly constrained to singular setups, necessitating substantial data and extensive training periods. Moreover, these methods have exhibited suboptimal performance in tasks requiring long-horizontal maneuvers, such as Radio Frequency Identification (RFID) inventory, where a robot requires thousands of steps to complete.

In this thesis, we address the aforementioned challenges by presenting the Cross-modal Reasoning Model (CMRM), a novel zero-shot Imitation Learning policy, to tackle long-horizontal robotic …

Evaluating The Effect Of Noise On Secure Quantum Networks, Karthick Anbalagan

Master's Theses

This thesis focuses on examining the resilience of secure quantum networks to environmental noise. Specifically, we evaluate the effectiveness of two well-known quantum key distribution (QKD) protocols: the Coherent One-Way (COW) protocol and Kak’s Three-Stage protocol (Kak06). The thesis systematically evaluates these protocols in terms of their efficiency, operational feasibility, and resistance to noise, thereby contributing to the progress of secure quantum communications. Using simulations, this study evaluates the protocols in realistic scenarios that include factors such as noise and decoherence. The results illustrate each protocol’s relative benefits and limitations, highlighting the three-stage protocol’s superior security characteristics, resistance to interference, …

Manufacturing Silicone In-House For The Creation Of Customized Neurovascular Blood Vessel Mimics, Jacob Wilbert Perisho

Master's Theses

The Tissue Engineering Lab at California Polytechnic State University San Luis Obispo focuses on creating tissue-engineered Blood Vessel Mimics (BVMs) designed for the preclinical testing of neurovascular devices. These BVMs are composed of silicone models, representing anatomically accurate neurovasculatures, that are sodded with vascular cell types and then cultivated in bioreactors (which maintain physiologic conditions). These silicone models are currently sourced externally from industry partners, so the primary goal of this thesis was to develop the means and methods for the Tissue Engineering Lab to manufacture silicone models in-house.

The first aim of this thesis was to develop and explore …

Cost-Risk Analysis Of The Ercot Region Using Modern Portfolio Theory, Megan Sickinger

Master's Theses

In this work, we study the use of modern portfolio theory in a cost-risk analysis of the Electric Reliability Council of Texas (ERCOT). Based upon the risk-return concepts of modern portfolio theory, we develop an n-asset minimization problem to create a risk-cost frontier of portfolios of technologies within the ERCOT electricity region. The levelized cost of electricity for each technology in the region is a step in evaluating the expected cost of the portfolio, and the historical data of cost factors estimate the variance of cost for each technology. In addition, there are several constraints in our minimization problem to …

Diegetic Sonification For Low Vision Gamers, Jhané Dawes

Master's Theses

There are not many games designed for all players that provide accommodations for low vision users. This means that low vision users may not get to engage with the gaming community in the same way as their sighted peers. In this thesis, I explore how diegetic sonification can be used as a tool to support these low vision gamers in the typical gaming environment. I asked low vision players to engage with a prototype game level with two diegetic sonification techniques applied, without the use of their corrective lenses. I found that participants had more enjoyment and experienced less difficulty …

Deep Learning Using Vision And Lidar For Global Robot Localization, Brett E. Gowling

Master's Theses

As the field of mobile robotics rapidly expands, precise understanding of a robot’s position and orientation becomes critical for autonomous navigation and efficient task performance. In this thesis, we present a snapshot-based global localization machine learning model for a mobile robot, the e-puck, in a simulated environment. Our model uses multimodal data to predict both position and orientation using the robot’s on-board cameras and LiDAR sensor. In an effort to minimize localization error, we explore different sensor configurations by varying the number of cameras and LiDAR layers used. Additionally, we investigate the performance benefits of different multimodal fusion strategies while …

Building Software At Scale: Understanding Productivity As A Product Of Software Engineering Intrinsic Factors, Gauthier Ingende Wa Boway

Master's Theses

During our education at KSU, we have learned about various factors that affect productivity such as schedule, budget, and risks, but those are often controlled outside of what we could learn as software engineering principles, patterns, or practices. On top of that, other off-work factors such as health conditions, emotional distress, or political climate, just to name a few, could drastically affect the productivity of a software engineering team. We see a demarcation between those factors that affect productivity in software engineering but are not inherent to the discipline itself, which we call resistance factors, and the factors that are …

Development Of An In Vitro 3-Dimensional Co-Culture Human Colorectal Cancer Model In Microfluidic Devices, Abby Jens

Master's Theses

Colorectal cancer is the second most common cause of cancer-related deaths in the United States, with the relative 5-year survival rate for distant stage cancer being only 14%. The most common treatment for colorectal cancer is with chemotherapeutic drugs; however, the discovery of these drugs is costly, time-consuming, and often requires the use of animal models that do not yield results that translate to clinical trials. Due to these shortcomings, researchers seek to develop physiologically relevant in vitro tumor models that more accurately mimic the tumor microenvironment for cheaper and faster high-throughput drug screening. The aim of this research was …

Comparison Of Scanning Electron Microscopy And Confocal Laser Microscopy For Tissue Surface Roughness Characterization, Tarnvir Dhaliwal

Master's Theses

It was found that the measurements captured by confocal microscopy and scanning electron microscopy had a statistically significant difference for bovine tissue. There was not a statistically significant for porcine and poultry tissue.

The intent of the study is to perform a comparative study to examine efficacy of two distinct technologies for a singular purpose: tissue surface roughness characterization. The two technologies compared are a confocal reflectance microscope and a scanning electron microscope. The comparison was made by comparing two surface roughness parameters [Ra and Rq] within ImageJ.

The study examined three different animal species [porcine, bovine, and poultry] to …

Finite Element Analysis Of The Bearing Component Of Total Ankle Replacement Implants During The Stance Phase Of Gait, Timothy S. Jain

Master's Theses

Total ankle replacement (TAR) implants are an effective option to restore the range of motion of the ankle joint for arthritic patients. An effective tool for analyzing these implants’ mechanical performance and longevity in-silico is finite element analysis (FEA). ABAQUS FEA was used to statically analyze the von Mises stress and contact pressure on the articulating surface of the bearing component in two newly installed fixed-bearing total ankle replacement implants (the Wright Medical INBONE II and the Exactech Vantage). This bearing component rotates on the talar component to induce primary ankle joint motion of plantarflexion and dorsiflexion. The stress response …

A Study Of Random Partitions Vs. Patient-Based Partitions In Breast Cancer Tumor Detection Using Convolutional Neural Networks, Joshua N. Ramos

Master's Theses

Breast cancer is one of the deadliest cancers for women. In the US, 1 in 8 women will be diagnosed with breast cancer within their lifetimes. Detection and diagnosis play an important role in saving lives. To this end, many classifiers with varying structures have been designed to classify breast cancer histopathological images. However, randomly partitioning data, like many previous works have done, can lead to artificially inflated accuracies and classifiers that do not generalize. Data leakage occurs when researchers assume that every image in a dataset is independent of each other, which is often not the case for medical …

Insights Into Cellular Evolution: Temporal Deep Learning Models And Analysis For Cell Image Classification, Xinran Zhao

Master's Theses

Understanding the temporal evolution of cells poses a significant challenge in developmental biology. This study embarks on a comparative analysis of various machine-learning techniques to classify cell colony images across different timestamps, thereby aiming to capture dynamic transitions of cellular states. By performing Transfer Learning with state-of-the-art classification networks, we achieve high accuracy in categorizing single-timestamp images. Furthermore, this research introduces the integration of temporal models, notably LSTM (Long Short Term Memory Network), R-Transformer (Recurrent Neural Network enhanced Transformer) and ViViT (Video Vision Transformer), to undertake this classification task to verify the effectiveness of incorporating temporal features into the classification …

A Sindy Hardware Accelerator For Efficient System Identification On Edge Devices, Michael Sean Gallagher

Master's Theses

The SINDy (Sparse Identification of Non-linear Dynamics) algorithm is a method of turning a set of data representing non-linear dynamics into a much smaller set of equations comprised of non-linear functions summed together. This provides a human readable system model the represents the dynamic system analyzed. The SINDy algorithm is important for a variety of applications, including high precision industrial and robotic applications. A Hardware Accelerator was designed to decrease the time spent doing calculations. This thesis proposes an efficient hardware accelerator approach for a broad range of applications that use SINDy and similar system identification algorithms. The accelerator is …

A Comparison Of Western And Eastern Soft Systems Approaches, John L. Anaya, John L. Anaya, John L. Anaya

Master's Theses

Soft System Approaches have been developed worldwide to help problem-solvers and decision-makers develop solutions to complex problems, such as aerospace systems. Soft System Approaches were designed to help lower the disorder of developing a complex system by increasing understanding of a situation. Four Soft System Approaches were investigated, two from the West and two from the East. Within the context of the paper, the West refers to thought patterns associated with thinkers and scientists in Europe and North America, and the East refers to those from and around China. The two from the West are Peter Checkland’s Soft Systems Methodology …