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3d Bioprinting Hydrogel For Tissue Engineering An Ascending Aortic Scaffold, Benjamin Stewart
3d Bioprinting Hydrogel For Tissue Engineering An Ascending Aortic Scaffold, Benjamin Stewart
Electronic Theses and Dissertations
The gold standard in 2016 for thoracic aortic grafts is Dacron®, polyethylene terephthalate, due to the durability over time, the low immune response elicited and the propensity for endothelialization of the graft lumen over time. These synthetic grafts provide reliable materials that show remarkable long term patency. Despite the acceptable performance of Dacron® grafts, it is noted that autographs still outperform other types of vascular grafts when available due to recognition of the host's cells and adaptive mechanical properties of a living graft. 3-D bioprinting patient-specific scaffolds for tissue engineering (TE) brings the benefits of non-degrading synthetic …
Mechanical Effects Of Surgical Adhesives On Ascending Thoracic Aortic Aneurysm Replacement, Dong Qiu
Mechanical Effects Of Surgical Adhesives On Ascending Thoracic Aortic Aneurysm Replacement, Dong Qiu
Electronic Theses and Dissertations
Ascending thoracic aortic aneurysm (aTAA) is a potentially lethal disease which grows gradually over time and may lead to aortic dissection and rupture. Currently, aTAA surgical repair using Dacron graft is a well-established treatment. In addition, surgical adhesives are frequently used in the surgeries to seal the anastomotic site. This study aims to investigate mechanical effects of four commonly used surgical adhesives, namely BioGlue, CoSeal, Crosseal, and Tisseel, on the suture site using in-vitro digital image correlation (DIC) method and finite element (FE) simulations in an ovine model. In this study, first, mechanical properties of ovine ascending aorta were obtained …
Statistical Shape And Intensity Modeling Of The Shoulder, Irene Sintini
Statistical Shape And Intensity Modeling Of The Shoulder, Irene Sintini
Electronic Theses and Dissertations
Anatomical variability in the shoulder is inherently present and can influence healthy and pathologic biomechanics and ultimately clinical decision-making. Characterizing variation in bony morphology and material properties in the population can support treatment and specifically the design, via shape and sizing, of shoulder implants. Total Shoulder Arthroplasty (TSA) is the treatment of choice for glenohumeral osteoarthritis as well as bone fracture. Complications and poor outcomes in TSA are generally influenced by the inability of the implant to replicate the natural joint biomechanics and by the bone quality around the fixation features. For this reason, knowledge of bony morphology and mechanical …