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A Metal-Free Approach To Biaryl Compounds: Carbon-Carbon Bond Formation From Diaryliodonium Salts And Aryl Triolborates, Kuruppu Lilanthi Jayatissa
A Metal-Free Approach To Biaryl Compounds: Carbon-Carbon Bond Formation From Diaryliodonium Salts And Aryl Triolborates, Kuruppu Lilanthi Jayatissa
Dissertations and Theses
Biaryl moieties are important structural motifs in many industries, including pharmaceutical, agrochemical, energy and technology. The development of novel and efficient methods to synthesize these carbon-carbon bonds is at the forefront of synthetic methodology. Since Ullmann’s first report of stoichiometric Cu-mediated homo-coupling of aryl halides, there has been a dramatic evolution in transition metal catalyzed biaryl cross-coupling reactions.
Our work focuses on the discovery and development of an unprecedented reagent combination for metal-free cross-coupling. It is hypothesized that direct carbon-carbon bond formation occurs via a triaryl-λ3-iodane and that electrophile/nucleophile pairing is critical for success in the reaction. Proof-of-concept …