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Characterizing The Controlled Release Of Glial Cell-Line Derived (Gdnf) Neurotrophic Factor From Encapsulated Schwann Cells, Kristy Broadrick Jan 2010

Characterizing The Controlled Release Of Glial Cell-Line Derived (Gdnf) Neurotrophic Factor From Encapsulated Schwann Cells, Kristy Broadrick

Wayne State University Theses

ABSTRACT

CHARACTERIZING THE CONTROLLED RELEASE OF GDNF IN SCHWANN CELLS

by

KRISTY BROADRICK

May 2010

Advisor: Dr. Pamela VandeVord

Major: Biomedical Engineering

Degree: Masters of Science

Controlled expression of glial cell line derived neurotrophic factor (GDNF) can be integrated in the development of a system for repair of injured peripheral nerves. This delivery strategy was demonstrated via inducible GDNF from microencapsulated cells in barium alginate. The Schwann cell line RT4-D6P2T was initially modified utilizing an ecdysone-based stable transfection system to produce RT4-GDNF cells. During construct preparation, it was found that C6 cells (where GDNF cDNA was isolated) make three GDNF …


Electroless Deposition Of Superconducting Magnesium Diboride Thin Films On Various Substrates, Khrupa Saagar Vijayaragavan Jan 2010

Electroless Deposition Of Superconducting Magnesium Diboride Thin Films On Various Substrates, Khrupa Saagar Vijayaragavan

Wayne State University Theses

ABSTRACT

ELECTROLESS DEPOSITION OF SUPERCONDUCTING MAGNESIUM DIBORIDE THIN FILMS ON VARIOUS SUBSTRATES

by

KHRUPA SAAGAR VIJAYARAGAVAN

MAY 2010

Advisor: Dr. Susil K Putatunda

Dr. Gavin Lawes

Major: Chemical Engineering

Degree: Masters of Science

Superconducting thin films of magnesium diboride were synthesized by a novel electroless plating process. Electroless plating shares many similarities to electroplating with the major difference being the absence of a continuous bias voltage. Significantly, this work represents the first investigation where electroless deposition has been used to prepare compounds, as opposed to the elemental metals considered in all previous studies. Magnesium Diboride is a recently discovered superconducting …


The Acute And Sub-Acute Effects Of Electrosurgical And Ultrasonic Surgical Devices On The Neurophysiologic Changes Of Sciatic Nerve Function, Anuja Gopalkrishna Vedpathak Jan 2010

The Acute And Sub-Acute Effects Of Electrosurgical And Ultrasonic Surgical Devices On The Neurophysiologic Changes Of Sciatic Nerve Function, Anuja Gopalkrishna Vedpathak

Wayne State University Theses

THE ACUTE AND SUB-ACUTE EFFECTS OF ELECTROSURGICAL AND ULTRASONIC SURGICAL DEVICES ON THE NEUROPHYSIOLOGIC CHANGES OF SCIATIC NERVE FUNCTION

Since the dawn of medicine, blood loss during surgeries has been one of the major concerns for the surgeons. Iatrogenic blood loss can have several harmful effects on the patient condition. With the rapid development in technology, the blood loss can now be significantly minimized by using a variety of vessel sealing devices that use several energy sources to seal the blood vessels or tissue bundles instead of traditional sutures and clips. These devices can be used in several general, colorectal, …


A Novel Image Processing Platform Development For Preprocessing Images With Two-Phase Microstructures Containing Isolated Particles, Yuxiu Zhang Jan 2010

A Novel Image Processing Platform Development For Preprocessing Images With Two-Phase Microstructures Containing Isolated Particles, Yuxiu Zhang

Wayne State University Theses

A novel image processing platform is developed in this thesis for pre-processing the images of two-phase microstructures containing isolated particles based on Matlab®. The two phases in this work represent martensite particles and ferrite matrix in Dual Phase steels that are developed for lightweight automotive body structures. An automated image processing tool is useful for obtaining statistical microstructure characteristics, important for better understanding material's deformation and fracture behavior. However, a generalized commercial software can not automatically realize the microstructural features of special interest, and a user-specified pre-processing tool is needed.

This platform utilizes the Matlab® GUI technique, Matlab image processing …


Effect Of Alternative Fuels On Aftertreatment Device, Bunpreet Singh Jan 2010

Effect Of Alternative Fuels On Aftertreatment Device, Bunpreet Singh

Wayne State University Theses

EFFECT OF ALTERNATIVE FUELS ON THE AFTERTREATMENT DEVICE.

by

BUNPREET SINGH

Dec 2010

Advisor: Dr. Dinu Taraza

Major: Mechanical Engineering

Degree: Master of Science

There is no doubt that globally, alternative fuels have attained the center of attention in order to reduce the dependency on fossil fuels. A lot of research has been conducted on the alternative fuels in the automotive industry pertaining to the sustainability, engine performance and the emission characteristics.

The focus of this study is to investigate the effect of alternative fuels (JP8, Soy-based B20, and S8) on the aftertreatment device. Different fuel properties (both physical and …


Digital Human Models Of People With Disabilities, Ron Hamameh Jan 2010

Digital Human Models Of People With Disabilities, Ron Hamameh

Wayne State University Theses

The current state-of-the-art in Digital Human Modeling (DHM) allows for full simulation and analysis of any task a person is required to perform at home, at work, in the military, in space, in sports, etc. The problem is that the software is missing a very important population: people with physical disabilities. What modifications and enhancements must be made to existing, commercially available DHM software to include this population?